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Purpura Fulminans

A severe, rapidly fatal reaction occurring most commonly in children following an infectious illness. It is characterized by large, rapidly spreading skin hemorrhages, fever, or shock. Purpura fulminans often accompanies or is triggered by DISSEMINATED INTRAVASCULAR COAGULATION.
Also Known As:
Fulminans, Purpura
Networked: 289 relevant articles (7 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Sepsis (Septicemia)
2. Septic Shock (Toxic Shock Syndrome)
3. Purpura
4. Adrenal Insufficiency (Adrenal Gland Hypofunction)
5. Protein C Deficiency

Experts

1. Schlievert, Patrick M: 3 articles (01/2014 - 04/2005)
2. Leclerc, F: 3 articles (11/2001 - 09/2000)
3. Fourier, C: 3 articles (11/2001 - 09/2000)
4. Esmon, C T: 3 articles (08/2001 - 05/2001)
5. Alhenc Gelas, Martine: 2 articles (02/2015 - 11/2014)
6. Knöfler, Ralf: 2 articles (02/2015 - 11/2014)
7. Nowak-Göttl, Ulrike: 2 articles (02/2015 - 11/2014)
8. Zieger, Barbara: 2 articles (02/2015 - 11/2014)
9. Junker, Ralf: 2 articles (02/2015 - 11/2014)
10. Holzhauer, Susanne: 2 articles (02/2015 - 11/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Purpura Fulminans:
1. Protein CIBA
2. Antithrombin IIIIBA
10/01/1994 - "Meningococcal purpura fulminans treated with antithrombin III concentrate: what is the optimal replacement therapy?"
12/01/2002 - "Significant advances have been made in understanding the physiopathology of the meningococcal purpura fulminans especially about the deleterious role of the deficiency of the protein C and the antithrombin III. It is too soon to advance that the prognosis of these diseases has been improved by these new therapeutic approaches but the results of preliminary clinical studies are encouraging. "
01/01/1990 - "Meningococcemia and purpura fulminans in adults: acute deficiencies of proteins C and S and early treatment with antithrombin III concentrates."
12/01/1997 - "Personal experience is reported on the efficacy of heparin in combination with antithrombin III in the treatment of purpura fulminans in two preterm neonates who did not have inherited deficiency of protein C or S and developed the disease possibly following prolonged labor (36 hours) in the first case, and maternal neoplasia, in the second. "
10/01/2013 - "Purpura fulminans is a life-threatening hematologic emergency characterized by extensive skin necrosis with hemorrhagic infarction, hypotension and gangrene which may arise from severe sepsis; mostly gram negative sepsis though also associated with some gram positive organisms, similarly viral infections like varicella and measles have been implicated; it may also arise from congenital deficiency of the anticoagulants protein C, S, and antithrombin III; and it may also be idiopathic. "
3. drotrecogin alfa activated (Xigris)FDA Link
4. Heparin (Liquaemin)FDA LinkGeneric
5. SteroidsIBA
6. CortisoneIBA
7. Ketoconazole (Nizoral)FDA LinkGeneric
8. EtomidateFDA LinkGeneric
9. Dacarbazine (DIC)FDA LinkGeneric
10. Adrenal Cortex Hormones (Corticosteroids)IBA

Therapies and Procedures

1. Hyperbaric Oxygenation
2. Amputation
3. Catheters
4. Transplants (Transplant)
5. Splenectomy