Multiple Pulmonary Nodules

A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.

Also Known As:

Networked: 101 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lung Neoplasms (Lung Cancer)
2.	Small Cell Carcinoma
3.	Proteinuria
4.	Neoplasms (Cancer)
5.	Granulomatosis with Polyangiitis (Wegener's Granulomatosis)

Experts

1.	Dubovy, Sander R: 1 article (10/2022)
2.	Galor, Anat: 1 article (10/2022)
3.	Karp, Carol L: 1 article (10/2022)
4.	Khzam, Rayan Abou: 1 article (10/2022)
5.	Rivas-Chacon, Rafael: 1 article (10/2022)
6.	Sripawadkul, Wathanee: 1 article (10/2022)
7.	Zein, Mike: 1 article (10/2022)
8.	Gartini, Sara: 1 article (05/2022)
9.	Kouismi, Hatim: 1 article (05/2022)
10.	Moueqqit, Othman: 1 article (05/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Pulmonary Nodules:

1.	Methylene Blue (Methylthioninium Chloride)FDA Link 01/01/2021 - "The aim of our study is to elucidate the efficacy of preoperative CT-guided methylene blue localization of both single and multiple pulmonary nodules. " 08/19/2022 - "Preoperative computed tomography-guided localization for multiple pulmonary nodules: comparison of methylene blue and coil." 01/01/2021 - "Conclusions: Preoperative CT-guided methylene blue localization for both single and multiple pulmonary nodules is safe, feasible, and effective." 01/01/2021 - "The success rate of preoperative CT-guided methylene blue localization for both single and multiple pulmonary nodules were comparable as 98.8% (333/337) vs. 100% (108/108). " 10/01/2022 - "For patients with multiple pulmonary nodules undergoing simultaneous surgery, indocyanine green injection under VNB can achieve a similar effect on pulmonary nodule localization as classical methylene blue injection under CT-guided percutaneous lung puncture, with shorter localization time and fewer complications."
2.	MelatoninIBA 01/01/2021 - "In this study, we found that a combined treatment of local radiofrequency ablation (RFA) and melatonin (MLT) greatly improved clinical outcomes for early lung cancer patients with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas. "
3.	Infliximab (Remicade)FDA Link 10/01/2015 - "This case highlights the differential diagnosis and work up for multiple pulmonary nodules that developed in a patient with CD who had been in remission on infliximab therapy. "
4.	Coloring Agents (Dyes)IBA 03/09/2022 - "This study aims to investigate and compare the efficacy and safety of the simultaneous and sequential patent blue dye (PBD) injections for identifying multiple pulmonary nodules during preoperative CT-guided localization. " 03/09/2022 - "Simultaneous Patent Blue Dye Injections Aid in the Preoperative CT-Guided Localization of Multiple Pulmonary Nodules." 10/01/2016 - "The aim of this study was to evaluate the usefulness of CT-guided Patent Blue V (PBV) dye localization in patients with multiple pulmonary nodules who underwent VATS. "
5.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 10/01/2022 - "A full diagnostic workup revealed multiple pulmonary nodules on chest imaging, proteinuria on urinalysis, and a positive c-antineutrophil cytoplasmic antibody on serological studies. " 06/01/2023 - "A 40-Year-Old Man With Multiple Pulmonary Nodules and Mediastinal Lymphadenopathy With Positive Anti-Neutrophil Cytoplasmic Antibody Reveals an Unexpected Diagnosis." 07/01/2007 - "ANCA-negative Wegener's granulomatosis should be considered when we diagnose multiple pulmonary nodules." 12/26/2012 - "SBE may present with positive c-ANCA/PR3, multiple pulmonary nodules, pulmonary polyangiitis, and glomerulonephritis clinically mimicking granulomatosis with polyangiitis (Wegener's granulomatosis)." 02/01/2009 - "The case of MPO-ANCA positive vasculitis associated with multiple pulmonary nodules following propylthiouracil treatment is very rare."
6.	DNA (Deoxyribonucleic Acid)IBA 02/01/2011 - "In this study, we measured CTCs and plasma DNA in a published group of patients with multiple pulmonary nodules and indeterminate metastatic disease. "
7.	sulfan blue (patent blue V)IBA 10/01/2016 - "The aim of this study was to evaluate the usefulness of CT-guided Patent Blue V (PBV) dye localization in patients with multiple pulmonary nodules who underwent VATS. "
8.	Methotrexate (Mexate)FDA LinkGeneric 11/01/2018 - "Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use. " 12/01/2017 - "Methotrexate-associated lymphoproliferative disease with multiple pulmonary nodules in a patient with rheumatoid arthritis." 01/01/2015 - "Methotrexate-associated Lymphoproliferative Disease with Multiple Pulmonary Nodules in a Patient with Rheumatoid Arthritis." 12/01/2019 - "Methotrexate-associated lymphoproliferative disorder with multiple pulmonary nodules and bilateral cervical lymphadenopathy." 01/01/2010 - "We report the case of a 60-year-old male with rheumatoid arthritis previously treated with methotrexate and cyclosporin, in whom multiple pulmonary nodules were disclosed. "
9.	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/01/2022 - "We enrolled patients with multiple pulmonary nodules who had undergone dynamic 18F-FDG PET/CT and divided them into sMPLC and IPM groups based on comprehensive features. " 11/01/2022 - "Syphilis With Multiple Pulmonary Nodules and Bone Lesions Detected on Computed Tomography and 18F Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography." 01/01/2019 - "18F-FDG PET/CT diagnostic performance in solitary and multiple pulmonary nodules detected in patients with previous cancer history: reports of 182 nodules." 11/01/2018 - "Further, positron emission tomography/CT revealed increased 18F fluorodeoxyglucose uptake in the left renal tumor, multiple pulmonary nodules, and bone metastatic tumor. "
10.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 11/01/2023 - "Electromagnetic navigation bronchoscopy-guided injection of indocyanine green in locating multiple pulmonary nodules: A case report." 10/01/2022 - "However, clinical work has demonstrated that intraoperative indocyanine green localization under electromagnetic navigation bronchoscopy/virtual navigation bronchoscopy (VNB) is more advantageous than conventional methods for patients with multiple pulmonary nodules undergoing simultaneous surgery, especially for those undergoing bilateral lung surgery. " 10/01/2022 - "Virtual navigation bronchoscopy-guided intraoperative indocyanine green localization in simultaneous surgery for multiple pulmonary nodules." 03/08/2022 - "Here, we report a case of hepatoblastoma (HB) with multiple pulmonary nodules that ultimately underwent complete resection using combined three-dimensional image reconstruction and indocyanine green (ICG) fluorescence guidance. " 10/01/2022 - "For patients with multiple pulmonary nodules undergoing simultaneous surgery, indocyanine green injection under VNB can achieve a similar effect on pulmonary nodule localization as classical methylene blue injection under CT-guided percutaneous lung puncture, with shorter localization time and fewer complications."

Therapies and Procedures

1.	Radiofrequency Ablation 03/01/2020 - "For patients with multiple pulmonary nodules who cannot tolerate surgical treatment, radiofrequency ablation (RFA) of multiple pulmonary lesions under the help of electromagnetic navigation system is a new treatment method. " 03/01/2007 - "From March 2005 to March 2006, 11 patients (seven men and four women) with single or multiple pulmonary nodules underwent radiofrequency ablation of 12 unresectable pulmonary tumours. " 01/01/2021 - "In this study, we found that a combined treatment of local radiofrequency ablation (RFA) and melatonin (MLT) greatly improved clinical outcomes for early lung cancer patients with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas. "
2.	Therapeutics 01/01/2018 - "This patient demonstrated resolution of multiple pulmonary nodules without toxicity on oral TRK inhibitor therapy. " 01/01/2015 - "We herein report the case of a RA patient who developed MTX-associated LPD with multiple pulmonary nodules during a 5-year course of MTX therapy. " 01/01/2007 - "Two years after the institution of oestrogen replacement therapy (HRT) a woman of 56 presented with haemoptysis which led to the discovery of multiple pulmonary nodules. " 08/01/1996 - "By multivariate analyses, factors associated with recurrence were pleural disease (p = 0.02), multiple pulmonary nodules (p = 0.03), and a poor response to cytoreductive therapy (p = 0.001). " 05/01/1992 - "Pulmonary hyalinizing granuloma itself is a rare benign disease with no specific therapy and is important in the differential diagnosis of lung diseases showing multiple pulmonary nodules."
3.	Drug Therapy (Chemotherapy) 01/01/1997 - "We describe a single case of small cell carcinoma of the lung presenting as multiple pulmonary nodules that seems to have been cured by chemotherapy." 02/01/2004 - "Patient 1 (aged 62 years) had multiple pulmonary nodules and underwent 2 separate lung biopsies, the first showing nodules composed of kappa light-chain deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to the lung and the second, obtained after chemotherapy 9 months later, showing only residual nodules without persistent lymphoma. " 06/01/1979 - "Clinically he had a mediastinal mass and bilateral multiple pulmonary nodules which showed a rapid growth despite cancer chemotherapy. " 03/01/2004 - "Approximately one year later, she was hospitalized because of metastatic disease with multiple pulmonary nodules, and a chemotherapy regimen consisting of paclitaxel and carboplatin was administered. " 10/01/2010 - "The following regimen of chemotherapy was given: each course consisted of ifosfamide (1,000 mg/m²) on days 1-5, adriamycin (60 mg/m²) on day 1, and cisplatin (15 mg/m²) on days 1-5. After 4 courses of the chemotherapy, the intraabdominal mass and multiple pulmonary nodules were reduced 45. "
4.	Injections 03/09/2022 - "Conclusions: Compared with the sequential method, simultaneous PBD injections may improve the localization success rate with a shorter procedure time and less radiation exposure if the patient with multiple pulmonary nodules can be approached in a single position. " 03/09/2022 - "Materials and Methods: Sixty-one consecutive patients with multiple pulmonary nodules who underwent preoperative CT-guided localization with PBD injections between January 2020 and December 2020 were retrospectively enrolled. " 03/09/2022 - "This study aims to investigate and compare the efficacy and safety of the simultaneous and sequential patent blue dye (PBD) injections for identifying multiple pulmonary nodules during preoperative CT-guided localization. " 03/09/2022 - "Simultaneous Patent Blue Dye Injections Aid in the Preoperative CT-Guided Localization of Multiple Pulmonary Nodules."
5.	Hysterectomy 12/01/2021 - "The authors present a clinical case of a 42-year-old woman, who underwent a hysterectomy 15 years ago due to myomas, admitted with multiple pulmonary nodules and abdominal mass, diagnosed by imaging tests, in the context of haemoptysis. " 04/01/2018 - "Seven years after she had a total abdominal hysterectomy for benign leiomyomas, a 46-year-old woman presented with a pelvic mass and multiple pulmonary nodules. " 07/01/2014 - "Benign metastasizing leiomyoma (BML) was initially used to describe single or multiple pulmonary nodules composed of proliferating smooth muscle cells (lacking cellular atypia) in premenopausal females 3 months to 20 y after hysterectomy for uterine leiomyoma. " 09/01/2011 - "A 48-year-old woman was admitted to our hospital because of multiple pulmonary nodules on the chest radiograph 7 years after total hysterectomy with removal of the left ovarium for uterine leiomyoma. " 06/01/2008 - "We describe the clinical and pathologic findings in a 49-year-old woman who had undergone hysterectomy 15 years before presentation was referred to evaluate for pulmonary metastases with typical radiologic findings of bilateral multiple pulmonary nodules. "