HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

Alkaline Ceramidase

A ceramidase subtype that is active at alkaline pH. It is found at high levels within the SMALL INTESTINE.

Also Known As:

Ceramidase, Alkaline

Networked: 24 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Amidohydrolases: 43
      - Ceramidases: 112
        Alkaline Ceramidase: 24
        Drosophila bwa protein
        human ACER1 protein
        human ACER2 protein
        human ACER3 protein
        mouse Acer1 protein
        mouse Acer2 protein
        S cerevisiae YPC1 protein

Experts

1.	Mao, Cungui: 8 articles (03/2020 - 09/2010)
2.	Xu, Ruijuan: 8 articles (03/2020 - 09/2010)
3.	Obeid, Lina M: 6 articles (01/2018 - 09/2010)
4.	Wang, Kai: 5 articles (03/2020 - 10/2015)
5.	Hannun, Yusuf A: 5 articles (01/2018 - 10/2015)
6.	Zhou, Jie: 4 articles (03/2020 - 10/2015)
7.	Lin, Chih-Li: 4 articles (01/2018 - 10/2015)
8.	Snider, Ashley J: 3 articles (01/2018 - 10/2015)
9.	Sun, Wei: 3 articles (01/2018 - 09/2010)
10.	Yi, Jae Kyo: 3 articles (01/2018 - 10/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2." 02/01/2022 - "Glioma patients after preoperative MRI diagnosis were enrolled, and LINC01087, microRNA (miR)-1277-5p, and alkaline ceramidase 3 (ACER3) levels were tested in glioma cancer tissue. " 04/15/2021 - "Acid (AC), neutral (NC) and alkaline ceramidase 3 (ACER3) are the most ubiquitous ceramidases and their therapeutic interest as targets in cancer diseases has been well sustained. " 07/01/2020 - "Human alkaline ceramidase 2 (ACER2), a key enzyme that regulates hydrolysis of cellular ceramides, affects cancer cell survival, however its role in HCC has not been well characterized. " 04/05/2016 - "Herein we demonstrate that DNA damage increases sphingosine levels in tumor cells by upregulating alkaline ceramidase 2 (ACER2) and that the upregulation of the ACER2/sphingosine pathway induces PCD in response to DNA damage by increasing the production of reactive oxygen species (ROS). "
2.	Hepatocellular Carcinoma (Hepatoma) 09/01/2018 - "Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling." 01/01/2022 - "Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p." 07/01/2020 - "Human alkaline ceramidase 2 promotes the growth, invasion, and migration of hepatocellular carcinoma cells via sphingomyelin phosphodiesterase acid-like 3B."
3.	Non-alcoholic Fatty Liver Disease 03/17/2020 - "Correction: Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress." 01/01/2020 - "Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress."
4.	Carcinogenesis 03/03/2016 - "Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system." 01/01/2022 - "Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p."
5.	Leukoencephalopathies 12/01/2021 - "Deficiency of alkaline ceramidase 3 with infancy-onset progressive leukoencephalopathy: a second case report." 01/01/2021 - "Mutation in Alkaline Ceramidase 3 (ACER3) gene which encodes alkaline ceramidase enzyme that plays a crucial role in cellular growth and viability has been stated as an uncommon reason for inherited leukoencephalopathies. "

Related Drugs and Biologics

1.	Ceramides
2.	Ceramidases
3.	Sphingolipids
4.	Enzymes
5.	Acid Ceramidase
6.	Sphingosine
7.	Acids
8.	Aggrecans (Aggrecan)
9.	MicroRNAs (MicroRNA)
10.	GTP-Binding Proteins (G-Protein)