Acid Ceramidase

A ceramidase subtype that is active at acid pH. It plays an important role in sphingolipid degradation by catalyzing the lysosomal hydrolysis of ceramide to sphingosine and free fatty acid. Inherited deficiency of acid ceramidase activity results in FARBER LIPOGRANULOMATOSIS.

Networked: 184 relevant articles (12 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bielawska, Alicja: 17 articles (01/2022 - 03/2004)
2.	Hannun, Yusuf A: 15 articles (11/2020 - 08/2006)
3.	Liu, Xiang: 14 articles (11/2020 - 08/2006)
4.	Levade, Thierry: 14 articles (01/2020 - 04/2007)
5.	Norris, James S: 12 articles (11/2020 - 08/2006)
6.	Schuchman, Edward H: 11 articles (01/2021 - 02/2002)
7.	Medin, Jeffrey A: 10 articles (01/2020 - 11/2008)
8.	Casas, Josefina: 8 articles (01/2021 - 04/2007)
9.	Bai, Aiping: 8 articles (11/2020 - 09/2007)
10.	Szulc, Zdzislaw M: 7 articles (01/2022 - 02/2008)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 11/01/2006 - "Taken together, our data demonstrated that Apoptin is a promising therapeutic agent for prostate cancer and that its function is improved when combined with acid ceramidase inhibitors." 03/01/2009 - "The current study on the effects of radiation on prostate cancer cells reveals that radiation programs an unpredicted resistance mechanism by upregulating acid ceramidase (AC). " 03/01/2004 - "This study provides the first insight into the effect of B13, an inhibitor of acid ceramidase, on human prostate cancer cell lines and xenografts. " 05/01/2013 - "Acid ceramidase as a therapeutic target in metastatic prostate cancer." 03/01/2009 - "Acid ceramidase upregulation in prostate cancer cells confers resistance to radiation: AC inhibition, a potential radiosensitizer."
2.	Neoplasms (Cancer) 12/23/2020 - "Acid ceramidase, a double-edged sword in cancer aggression: A minireview." 06/01/2019 - "Acid ceramidase is over expressed in a variety of cancers and has a role as a potential target for inhibition by novel specific inhibitors or off-target effects of traditional anti-cancer agents. " 06/01/2019 - "Over expression of acid ceramidase has been demonstrated in a number of human cancers. " 03/01/2019 - "Acid ceramidase, an emerging target for anti-cancer and anti-angiogenesis." 01/01/2019 - "Acid Ceramidase: A Novel Therapeutic Target in Cancer."
3.	Farber Lipogranulomatosis 01/01/2023 - "rAAV-mediated over-expression of acid ceramidase prevents retinopathy in a mouse model of Farber lipogranulomatosis." 01/01/2022 - "Farber disease (FD) is an extremely rare autosomal recessive disorder caused by the deficiency of lysosomal acid ceramidase. " 01/01/2020 - "In a mouse model of Farber disease with a decrease of acid ceramidase activity, we observed a strong, up to 50-fold increase of 1-OACs in lung, thymus, and spleen. " 01/01/2019 - "Farber disease (FD) is a rare, lysosomal storage disorder caused by deficient acid ceramidase activity. " 01/01/2018 - "Farber Disease (FD) is an ultra-rare Lysosomal Storage Disorder caused by deficient acid ceramidase (ACDase) activity. "
4.	Cystic Fibrosis (Mucoviscidosis) 01/01/2021 - "Most importantly, the overexpression of acid ceramidase protects cystic fibrosis mice from pulmonary P. " 01/01/2019 - "Recent studies indicated that an inhalation treatment of cystic fibrosis mice with acid ceramidase prevents and eliminates infections with Pseudomonas aeruginosa and Stapyhlococcus aureus. " 01/01/2021 - "aeruginosa infections in cystic fibrosis, is normalized in cystic fibrosis airways upon the overexpression of acid ceramidase. " 01/01/2021 - "Here, we tested whether the genetic overexpression of acid ceramidase rescues cystic fibrosis mice from pulmonary infections with P. " 01/01/2021 - "Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections."
5.	Infections 01/01/2019 - "Recent studies indicated that an inhalation treatment of cystic fibrosis mice with acid ceramidase prevents and eliminates infections with Pseudomonas aeruginosa and Stapyhlococcus aureus. " 01/01/2023 - "Acid ceramidase expression in air-liquid interface cultured human bronchial epithelial cell had significantly increased after 6 h of Pseudomonas aeruginosa infection, while it had decreased significantly after 24 h of infection. " 01/01/2021 - "aeruginosa infections in cystic fibrosis, is normalized in cystic fibrosis airways upon the overexpression of acid ceramidase. " 01/01/2021 - "Here, we tested whether the genetic overexpression of acid ceramidase rescues cystic fibrosis mice from pulmonary infections with P. " 01/01/2021 - "Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections."

Related Drugs and Biologics

1.	Ceramides
2.	Sphingosine
3.	carmofur
4.	Fenretinide
5.	Antineoplastic Agents (Antineoplastics)
6.	(2R,3Z)- N- (1- hydroxyoctadec- 3- en- 2- yl)pivalamide
7.	Glutathione Transferase (Glutathione S-Transferase)
8.	Temozolomide (Temodar)
9.	Inflammasomes
10.	Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Drug Therapy (Chemotherapy)
4.	Photochemotherapy (Photodynamic Therapy)
5.	Neoadjuvant Therapy