|1.||Liu, Xiang: 12 articles (12/2014 - 08/2006)|
|2.||Hannun, Yusuf A: 10 articles (12/2014 - 08/2006)|
|3.||Norris, James S: 10 articles (10/2013 - 08/2006)|
|4.||Bielawska, Alicja: 9 articles (12/2014 - 03/2004)|
|5.||Levade, Thierry: 8 articles (01/2014 - 04/2007)|
|6.||Casas, Josefina: 7 articles (06/2013 - 04/2007)|
|7.||Schuchman, Edward H: 6 articles (09/2014 - 02/2002)|
|8.||Cheng, Joseph C: 6 articles (10/2013 - 08/2006)|
|9.||Turner, Lorianne S: 6 articles (11/2012 - 09/2007)|
|10.||Elojeimy, Saeed: 6 articles (12/2009 - 08/2006)|
|1.||Prostatic Neoplasms (Prostate Cancer)
11/01/2006 - "Taken together, our data demonstrated that Apoptin is a promising therapeutic agent for prostate cancer and that its function is improved when combined with acid ceramidase inhibitors."
03/01/2009 - "The current study on the effects of radiation on prostate cancer cells reveals that radiation programs an unpredicted resistance mechanism by upregulating acid ceramidase (AC). "
10/01/2015 - "Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP."
05/01/2013 - "Acid ceramidase as a therapeutic target in metastatic prostate cancer."
03/01/2011 - "Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide."
04/11/2015 - "Deficiency in acid ceramidase is the molecular basis of Farber disease. "
01/01/2014 - "Farber disease is an inherited metabolic disorder caused by mutations in the acid ceramidase gene, which leads to ceramide accumulation in lysosomes. "
06/01/2013 - "Farber disease (FD) is a severe inherited disorder of lipid metabolism characterized by deficient lysosomal acid ceramidase (ACDase) activity, resulting in ceramide accumulation. "
06/01/2012 - "Farber disease (MIM 228000) is a rare autosomal recessive condition caused by deficiency of lysosomal acid ceramidase (EC 126.96.36.199). "
12/01/2010 - "A simple fluorogenic method for determination of acid ceramidase activity and diagnosis of Farber disease."
|3.||Breast Neoplasms (Breast Cancer)
08/28/2015 - "We aimed at targeting this enzyme with a small molecule acid ceramidase inhibitor, Ceranib 2 in human breast cancer cell lines MCF 7 and MDA MB 231. "
12/01/2009 - "Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer."
01/01/2015 - "Acid ceramidase is associated with an improved prognosis in both DCIS and invasive breast cancer."
08/28/2015 - "Being upregulated in the tumors of breast, acid ceramidase acts as a potential target for breast cancer therapy. "
06/01/2012 - "C6-ceramide and targeted inhibition of acid ceramidase induce synergistic decreases in breast cancer cell growth."
|4.||Noninfiltrating Intraductal Carcinoma (DCIS)
12/15/2014 - "Acid ceramidase (ACDase) is being recognized as a therapeutic target for cancer. "
05/01/2013 - "Acid ceramidase (AC), a key enzyme of sphingolipid metabolism, seems to play an important role in cancer progression. "
03/01/2013 - "Acid ceramidase (AC) occupies an important place in the control of cancer cell proliferation. "
01/01/2013 - "Immunohistochemical analysis of a human prostate tissue microarray revealed that nuclear PTEN was lost in patients whose tumors had elevated acid ceramidase. "
01/01/2013 - "Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity."
|9.||Small Interfering RNA (siRNA)
|1.||Transplantation (Transplant Recipients)
|2.||Heterologous Transplantation (Xenotransplantation)
|3.||Drug Therapy (Chemotherapy)