Ceramidases

Amidohydrolases that are specific for the cleavage of the N-acyl linkage of CERAMIDES. Ceramidases are classified as acidic, neutral or basic according to the optimal pH with which they function.

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Networked: 59 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hannun, Yusuf A: 3 articles (08/2014 - 04/2002)
2.	Casas, Josefina: 3 articles (08/2014 - 08/2011)
3.	Huwiler, Andrea: 3 articles (02/2013 - 01/2006)
4.	Levade, Thierry: 2 articles (08/2014 - 08/2011)
5.	Fabrias, Gemma: 2 articles (08/2014 - 11/2011)
6.	Bhabak, Krishna P: 2 articles (02/2013 - 10/2012)
7.	Arenz, Christoph: 2 articles (02/2013 - 10/2012)
8.	Zhu, Hongling: 2 articles (05/2012 - 07/2011)
9.	Lopez-Rosas, Aurora: 2 articles (05/2012 - 07/2011)
10.	Sandhoff, Konrad: 2 articles (01/2012 - 02/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2011 - "B13 analogues are being considered as therapeutic agents for cancer cells, since B13 is a ceramide analogue and inhibits ceramidase to promote apoptosis in cancer cells. " 02/01/2001 - "Ceramidase inhibition increases the ceramide content of tumor cells, resulting in maximum activation of the apoptotic cascade. " 04/05/1997 - "This method was sensitive and qualitative and enabled the detection of ceramidase activity in invertebrates for the first time as well as in several human cancer cell lines." 02/15/2013 - "Induction of apoptosis mediated by the inhibition of ceramidases has been shown to enhance the efficacy of conventional chemotherapy in several cancer models. " 10/15/2012 - "Inhibition of ceramidases has been shown to induce apoptosis and to increase the efficacy of conventional chemotherapy in several cancer models. "
2.	Farber Lipogranulomatosis 04/01/1995 - "Sulfatide and sphingomyelin loading of living cells as tools for the study of ceramide turnover by lysosomal ceramidase--implications for the diagnosis of Farber disease." 10/04/2001 - "The role of ceramide in receptor- and stress-induced apoptosis studied in acidic ceramidase-deficient Farber disease cells." 04/01/1995 - "Our data with this novel method show that sphingomyelin loading of intact living cells is a simple, alternative means for determining ceramide degradation by lysosomal ceramidase and for diagnosing Farber disease." 08/30/1993 - "The time course of degradation of a radiolabelled natural ceramide has been studied in intact, living lymphoid cells and skin fibroblasts from normal individuals and from patients affected with Farber disease, an inborn disorder of ceramide metabolism due to deficient activity of lysosomal ceramidase. " 08/01/1982 - "Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls."
3.	Prostatic Neoplasms (Prostate Cancer) 11/01/2015 - "This study investigates the potential for ceranib-2, a novel ceramidase inhibitor, to affect the survival and/or promote apoptosis of prostate cancer cells (LNCaP and DU145) in vitro. " 11/01/2015 - "Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2." 08/10/2003 - "N-oleoylethanolamine (OE), an inhibitor of acidic ceramidase, consistently potentiated the apoptotic effects of PD153035 in all the prostatic cancer cell lines tested. " 06/15/2003 - "The apoptotic/necrotic responses induced by ANA on these prostatic cancer cells were also potentiated by the acidic ceramidase inhibitor, N-oleoylethanolamine and partially inhibited by the specific ceramide synthetase inhibitor, fumonisin B1 indicating that these cytotoxic actions of ANA might be induced via the cellular ceramide production. "
4.	Schizophrenia (Dementia Praecox) 02/01/2012 - "To study the involvement of the N-acylsphingosine amidohydrolase 1 gene (ASAH1) in the susceptibility to schizophrenia in the Han Chinese population. " 02/01/2012 - "Identification of the N-acylsphingosine amidohydrolase 1 gene (ASAH1) for susceptibility to schizophrenia in a Han Chinese population."
5.	Atopic Dermatitis (Atopic Eczema) 12/01/2013 - "Pertinently, alterations of lipid profile, including ceramide and ceramidase activities occur in atopic dermatitis (AD). " 01/01/2012 - "It is considered that the mechanism by which PrA prevents the skin from drying involves the inhibition of increased ceramidase expression associated with atopic dermatitis." 09/01/2009 - "It was demonstrated that oral supplementation with LE extract prevented the development of atopic dermatitis with reducing ceramide degradation coupled with a low expression of ceramidase protein." 01/01/1999 - "Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis." 06/05/1998 - "We report here a novel type of ceramidase of Pseudomonas aeruginosa AN17 isolated from the skin of a patient with atopic dermatitis. "

Related Drugs and Biologics

1.	Acid Ceramidase
2.	Sphingomyelin Phosphodiesterase (Sphingomyelinase)
3.	Enzymes
4.	sphingosine kinase
5.	N-oleoylethanolamine
6.	ceramide glucosyltransferase
7.	Ceramidases
8.	Sphingosine
9.	Proteins (Proteins, Gene)
10.	Type C Phospholipases

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)