delta-Globins

A member of the beta-globin family. In humans, delta-globin is encoded in the beta-globin gene cluster located on CHROMOSOME 11. Two delta-globin chains along with two alpha-globin chains form HEMOGLOBIN A2 which makes up about 3% of the HEMOGLOBIN in adults.

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Networked: 54 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Poddie, Daniela: 3 articles (01/2021 - 11/2003)
2.	Porcu, Susanna: 3 articles (01/2021 - 11/2003)
3.	Dutly, Fabrizio: 3 articles (01/2010 - 01/2005)
4.	Frischknecht, Hannes: 3 articles (01/2010 - 01/2005)
5.	Barella, Susanna: 2 articles (01/2021 - 01/2020)
6.	Marongiu, Maria F: 2 articles (01/2021 - 11/2003)
7.	Perseu, Lucia: 2 articles (01/2021 - 01/2020)
8.	Ristaldi, Maria S: 2 articles (01/2021 - 11/2003)
9.	Simbula, Michela: 2 articles (01/2021 - 01/2020)
10.	Carestia, Clementina: 2 articles (02/2010 - 02/2002)

Related Diseases

1.	delta-Thalassemia 08/01/1988 - "In this study, we used cloning and sequence analysis to define the molecular defect in two delta-thalassemia genes, one associated with reduced output of delta-globin chains (delta +thal) from a Sardinian and the other with a complete suppression of delta-chain production from the affected locus (delta zerp thal) from a Southern Italian. " 08/01/2021 - "Delta-thalassemia is noted when mutations occur on the delta-globin gene. " 12/01/2006 - "Although delta-globin gene (HBD MIM#142000) mutations have no clinical implications, co-inheritance of beta- and delta-thalassemia may lead to misdiagnosis. " 01/01/2005 - "Two new delta-globin mutations: Hb A2-Ninive [delta133(H11)Val-Ala] and a delta(+)-thalassemia mutation [-31 (A --> G)] in the TATA box of the delta-globin gene." 11/01/2003 - "delta-Globin gene activation has been proposed as a potential therapeutic tool for the cure of delta-thalassemia (thal). "
2.	beta-Thalassemia (Cooley's Anemia) 02/01/2002 - "The finding of the new variant increases the genotype heterogeneity of the delta-globin gene in the Mediterranean area, and is relevant to the study and prevention of Cooley's Anemia." 12/01/2006 - "Among 7,153 samples studied for beta-thalassemia, 205 samples with lower than expected HbA2 levels were selected for our analysis and 183 samples (2.5%) were positive for delta-globin gene mutations. " 08/01/2003 - "Mutation at -30 (T-->C) of the delta-globin gene in a Taiwanese beta-thalassemia carrier." 05/01/2001 - "Normal delta globin gene sequence in carrier of the silent-101 (C-T) beta-thalassemia mutation with normal HbA2 level." 12/01/1982 - "The delta-globin and beta +-thalassemia genes may be evolving pseudogenes. "
3.	Thalassemia 01/01/2010 - "We report the characterization of five novel delta-globin gene mutations detected during routine screening for thalassemia. " 01/01/1997 - "These changes are either linked in cis with other mutations or are responsible for thalassemias or for positive regulatory effect in delta-globin gene expression. " 09/01/1987 - "A delta-globin gene derived from patients with homozygous delta zero-thalassemia functions normally on transient expression in heterologous cells." 12/01/1982 - "The existence of delta O-thalassemia and the presence of delta-globin genes in this condition recall the molecular findings in most types of beta O-thalassemia. " 02/01/2011 - "The aim of this review is to study the frequency of common and the occurrence of rare and novel mutations of the delta-globin gene and of Hb Lepore defects that might interfere with thalassemia diagnostics and to report the rationale of HbA2 estimation in the presence of delta- or alpha-gene mutations. "
4.	Acute Erythroblastic Leukemia (Erythroleukemia) 11/01/2003 - "The delta-globin gene is also expressed in the human erythroleukemia cell line K562. " 02/01/1992 - "Previous analysis of the hemoglobin phenotype of the K562 human erythroleukemia cell line showed regulated expression of the epsilon-, zeta-, gamma-, alpha-, and delta-globin genes. " 04/05/1987 - "To determine whether sequences contained within the small intervening sequence (IVS 1) or large intervening sequence (IVS 2) are involved in the regulated expression of the human beta-globin gene, chimeric genes containing portions of the human beta- and delta-globin genes were stably transfected into mouse erythroleukemia (MEL) cells. " 09/01/2001 - "We previously showed that the 651-bp DNA fragment, located 3 kb upstream from the human delta-globin gene (fragment F5), is able to inhibit adult, not fetal, globin promoter in mouse erythroleukemia cell lines (MEL) expressing adult globin genes. " 11/15/1996 - "To test the feasibility of this strategy, we inserted the beta-globin CACCC box at -90 of the delta-globin gene promoter to produce an HS2 delta CAC-beta construct and quantitated human delta- and beta-globin mRNA in stably transformed murine erythroleukemia (MEL) cells. "
5.	Delta-Beta Thalassemia 09/15/1992 - "The Spanish type of delta beta-thalassemia is a mild thalassemic condition due to a large deletion starting at the Alu I repeat between the A gamma and delta-globin genes immediately 3' to the RIH probe and extending 11 and 17 kb downstream of the 3' endpoints of HPFH 1 and HPFH 2, respectively. " 01/01/1992 - "The analysis of the delta-globin gene from the delta beta-thalassemia chromosome revealed an entirely normal sequence. " 01/01/1992 - "Normal delta-globin gene sequences in Sardinian nondeletional delta beta-thalassemia." 09/01/1988 - "Extensive restriction endonuclease mapping defined the 5' breakpoint within the IVS II of the delta-globin gene, between positions 775 to 781 very similar to the 5' breakpoint of the Sicilian delta beta-thalassemia. " 01/16/1985 - "Persistent expression of the gamma-globin gene in adult life has been supposed to be caused by loss of a region located about 3-4 kb 5' to the delta-globin gene from comparison of the extents of deletions in several different forms of delta beta-thalassemia and HPFH (hereditary persistence of fetal hemoglobin). "

Related Drugs and Biologics

1.	Enzymes
2.	beta-Globins (beta Globin)
3.	Codon (Codons)
4.	Messenger RNA (mRNA)
5.	hemoglobin Lepore
6.	DNA (Deoxyribonucleic Acid)
7.	Globins
8.	hemoglobin A2'
9.	gamma-Globins
10.	Intergenic DNA (Junk DNA)