|1.||Frischknecht, Hannes: 3 articles (01/2010 - 01/2005)|
|2.||Dutly, Fabrizio: 3 articles (01/2010 - 01/2005)|
|3.||Carestia, Clementina: 2 articles (02/2010 - 02/2002)|
|4.||Giordano, P C: 1 article (02/2011)|
|5.||Arkesteijn, S G J: 1 article (02/2011)|
|6.||Gallivan, M V E: 1 article (02/2011)|
|7.||Harteveld, C L: 1 article (02/2011)|
|8.||Phylipsen, M: 1 article (02/2011)|
|9.||Kordafshari, Alireza: 1 article (01/2011)|
|10.||Zeinali, Sirous: 1 article (01/2011)|
12/15/1991 - "Screening for molecular defects that cause delta-thalassemia or unstable delta-globin by PCR amplification and restriction enzyme digestion will lead to correct diagnosis of beta/delta-thalassemia compound heterozygotes and improved genetic counseling."
08/01/1988 - "In this study, we used cloning and sequence analysis to define the molecular defect in two delta-thalassemia genes, one associated with reduced output of delta-globin chains (delta +thal) from a Sardinian and the other with a complete suppression of delta-chain production from the affected locus (delta zerp thal) from a Southern Italian. "
01/01/2005 - "Two new delta-globin mutations: Hb A2-Ninive [delta133(H11)Val-Ala] and a delta(+)-thalassemia mutation [-31 (A --> G)] in the TATA box of the delta-globin gene."
11/01/2003 - "delta-Globin gene activation has been proposed as a potential therapeutic tool for the cure of delta-thalassemia (thal). "
01/01/1997 - "Scanning method to identify the molecular heterogeneity of delta-globin gene especially in delta-thalassemias: detection of three novel substitutions in the promoter region of the gene."
|2.||beta-Thalassemia (Cooley's Anemia)
02/01/2002 - "The finding of the new variant increases the genotype heterogeneity of the delta-globin gene in the Mediterranean area, and is relevant to the study and prevention of Cooley's Anemia."
12/01/2006 - "Among 7,153 samples studied for beta-thalassemia, 205 samples with lower than expected HbA2 levels were selected for our analysis and 183 samples (2.5%) were positive for delta-globin gene mutations. "
08/01/2003 - "Mutation at -30 (T-->C) of the delta-globin gene in a Taiwanese beta-thalassemia carrier."
05/01/2001 - "Normal delta globin gene sequence in carrier of the silent-101 (C-T) beta-thalassemia mutation with normal HbA2 level."
09/15/1992 - "The Spanish type of delta beta-thalassemia is a mild thalassemic condition due to a large deletion starting at the Alu I repeat between the A gamma and delta-globin genes immediately 3' to the RIH probe and extending 11 and 17 kb downstream of the 3' endpoints of HPFH 1 and HPFH 2, respectively. "
01/01/2010 - "We report the characterization of five novel delta-globin gene mutations detected during routine screening for thalassemia. "
02/15/1999 - "We have tested this hypothesis for an element that covers the minimal distance between the thalassemia and HPFH deletions and is thought to be responsible for the difference between a deletion HPFH and deltabeta-thalassemia, located 5' of the delta-globin gene. "
01/01/1997 - "These changes are either linked in cis with other mutations or are responsible for thalassemias or for positive regulatory effect in delta-globin gene expression. "
09/01/1987 - "A delta-globin gene derived from patients with homozygous delta zero-thalassemia functions normally on transient expression in heterologous cells."
12/01/1982 - "The existence of delta O-thalassemia and the presence of delta-globin genes in this condition recall the molecular findings in most types of beta O-thalassemia. "
|4.||Acute Erythroblastic Leukemia (Erythroleukemia)
11/01/2003 - "The delta-globin gene is also expressed in the human erythroleukemia cell line K562. "
02/01/1992 - "Previous analysis of the hemoglobin phenotype of the K562 human erythroleukemia cell line showed regulated expression of the epsilon-, zeta-, gamma-, alpha-, and delta-globin genes. "
04/05/1987 - "To determine whether sequences contained within the small intervening sequence (IVS 1) or large intervening sequence (IVS 2) are involved in the regulated expression of the human beta-globin gene, chimeric genes containing portions of the human beta- and delta-globin genes were stably transfected into mouse erythroleukemia (MEL) cells. "
09/01/2001 - "We previously showed that the 651-bp DNA fragment, located 3 kb upstream from the human delta-globin gene (fragment F5), is able to inhibit adult, not fetal, globin promoter in mouse erythroleukemia cell lines (MEL) expressing adult globin genes. "
11/15/1996 - "To test the feasibility of this strategy, we inserted the beta-globin CACCC box at -90 of the delta-globin gene promoter to produce an HS2 delta CAC-beta construct and quantitated human delta- and beta-globin mRNA in stably transformed murine erythroleukemia (MEL) cells. "
03/15/2010 - "The human delta-globin chain, unique to the hemoglobin A2 (HbA2) heterotetramer, is important for the evaluation of hemoglobinopathy. "
06/01/1999 - "These findings have potential relevance for the future prospective treatment of inherited hemoglobinopathies based on the conversion of the low functioning delta-globin gene into a high functioning beta-like globin gene."
|1.||beta-Globins (beta Globin)
|3.||Messenger RNA (mRNA)
|5.||DNA (Deoxyribonucleic Acid)
|8.||Intergenic DNA (Junk DNA)
|9.||Fetal Hemoglobin (Hemoglobin F)