|1.||Fucharoen, Suthat: 11 articles (02/2012 - 06/2005)|
|2.||Harteveld, Cornelis L: 11 articles (08/2010 - 08/2002)|
|3.||Giordano, Piero C: 10 articles (08/2010 - 08/2002)|
|4.||Higgs, Douglas R: 9 articles (01/2010 - 06/2003)|
|5.||Winichagoon, Pranee: 8 articles (05/2010 - 06/2005)|
|6.||Viprakasit, Vip: 7 articles (03/2010 - 02/2004)|
|7.||Svasti, Saovaros: 6 articles (02/2012 - 05/2008)|
|8.||Galanello, Renzo: 5 articles (01/2014 - 09/2009)|
|9.||Weiss, Mitchell J: 5 articles (10/2010 - 10/2002)|
|10.||Kanavakis, Emmanuel: 5 articles (09/2009 - 01/2004)|
11/01/2000 - "In a study of 232 individuals referred for molecular evaluation of anemia, 303 chromosomes carried alpha-globin gene abnormalities; 6 gene rearrangements and 11 point mutations were identified. "
09/01/1988 - "In addition, these studies suggest that small decreases in the amount of excess alpha-globin chains can significantly ameliorate the severity of anemia in the beta-thalassemic mouse."
08/01/2008 - "Excess alpha-globin precipitates in erythroid progenitor cells resulting in cell death, ineffective erythropoiesis and severe anemia. "
07/01/2007 - "Thus, compound mutants lacking both Ahsp and 1 of 4 alpha-globin genes (genotype Ahsp(-/-)alpha-globin*(alpha/alphaalpha)) exhibited more severe anemia and Hb instability than mice with either mutation alone. "
01/01/2006 - "The rationale behind this approach is to pair the excess normal alpha-globin chain with the alternative fetal gamma-chain to promote red blood cell survival and ameliorate the anemia. "
|2.||beta-Thalassemia (Cooley's Anemia)
03/01/2010 - "This study revealed that all the three reported loci and the alpha-globin gene locus are the best and common predictors of the disease severity in beta-thalassemia."
06/01/2009 - "To study the effect of liposomal transfection of antisense oligonucleotide (ASON) on the erythroid cell alpha-globin gene in the patients with severe beta-thalassemia, and provide a new idea for beta-thalassemia gene therapy. "
10/01/2007 - "The objective of study was to investigate the effect of liposomal transfection of antisense oligodeoxynucleotide (ASON) on alpha-globin gene expression and proliferation of K562 cells, to explore the new way of gene therapy in beta-thalassemia. "
04/01/2006 - "There are few studies investigating alpha globin gene triplications in beta-thalassemia in Asian Indians and its effect on phenotype, which was the primary aim of this study. "
07/01/2004 - "In this study, the frequency of alpha globin gene deletions was studied in the beta-thalassemia trait, the mildest form of the disorder. "
09/01/2009 - "The excessive unbound alpha-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis. "
01/01/2008 - "This is predicted to result in precipitation of the unstable alpha chains or Hb variant, a concomitant decrease in the overall quantity of normal alpha-globin in the red cells and a potential degree of anemia and possibly, hemolysis. "
07/01/1972 - "Equal synthesis is probably due both to a decrease in alpha-chain synthesis and an increase in beta-chain synthesis in bone marrow erythroid cells and may contribute to the absence of overt hemolysis due to excess alpha-globin chain accumulation in heterozygous beta-thalassemia."
05/01/1999 - "It is concluded that the coinheritance of microdeletions in the alpha-globin gene locus in SSA patients confers "renoprotection" by mechanisms not related to the degree of anemia or the severity of hemolysis, but could be related to a reduced mean corpuscular volume or to a lower erythrocyte hemoglobin concentration."
05/01/2006 - "The results revealed that one of the possible molecular mechanism of the effects caused by Yisui Shengxue Granules is that it can up-regulate the expression levels of AHSP and erythroid transcription factor GATA-1 mRNAs, enhance the protein synthesis of AHSP which can bind the relative excess free alpha-globin, prevent the formation of alpha -globin-cytotoxic precipitates in red blood cells and decrease the hemolysis."
04/01/1998 - "However, splenomegaly was more common as compared to the patients with a normal alpha-globin genotype. "
02/01/1988 - "The frequency of splenomegaly was not influenced by the alpha globin genotype. "
10/29/2002 - "Free alpha globin chains were completely cleared from red blood cell membranes, splenomegaly abated, and iron deposit was almost eliminated in liver sections. "
06/01/2003 - "Information, prospectively collected, included molecular defects, donor genotype, beta/alpha-globin expression rates, serum ferritin levels, hepato-splenomegaly, chelation history, virology screening, liver pathology together with post-transplant outcome inclusive of leucocyte chimerism. "
05/01/1987 - "Five patients with heterozygous beta-thalassaemia with an unusually severe clinical picture, low haemoglobin levels occasionally requiring blood transfusion, splenomegaly and unusually prominent basophilic stippling were found to have co-inherited a triple alpha-globin gene arrangement on one chromosome (alpha alpha alpha/alpha alpha). "
04/01/1987 - "The loss of alpha-globin gene transcriptional activity rarely occurs as an acquired abnormality during the evolution of myeloproliferative disease or preleukemia. "
10/01/1983 - "Acquired alpha-thalassemia in preleukemia is due to decreased expression of all four alpha-globin genes."
10/01/1983 - "A somatic mutation(s), acquired during the evolution of preleukemia in a 75-year-old Caucasian male of North European origin, resulted in a marked decrease in alpha-globin mRNA. "
08/01/1983 - "The presence of hemoglobin H (beta 4), resulting from a deficiency of alpha-globin chain synthesis, was observed as an acquired characteristic in the red cells of five elderly patients with myeloproliferative disorders or preleukemia. "
04/01/1987 - "These data showed that factor(s) in the mouse erythroleukemia cell can genetically complement the alpha-globin gene defect in these preleukemia patients with acquired hemoglobin H disease and suggest that altered expression of a gene in trans to the alpha-globin gene may be responsible for the acquisition of hemoglobin H disease in these patients."
|1.||Messenger RNA (mRNA)
|4.||Fetal Hemoglobin (Hemoglobin F)
|6.||RNA (Ribonucleic Acid)
|7.||beta-Globins (beta Globin)
|8.||DNA Restriction Enzymes (Restriction Endonuclease)
|10.||DNA (Deoxyribonucleic Acid)
|3.||Blood Transfusion (Blood Transfusions)