|1.||Kadowaki, Takashi: 11 articles (12/2011 - 11/2002)|
|2.||Terauchi, Yasuo: 10 articles (05/2014 - 11/2002)|
|3.||White, Morris F: 10 articles (07/2013 - 01/2002)|
|4.||Shaw, Leslie M: 6 articles (12/2011 - 11/2004)|
|5.||Tobe, Kazuyuki: 6 articles (06/2006 - 06/2003)|
|6.||Suzuki, Ryo: 6 articles (06/2006 - 06/2003)|
|7.||Shulman, Gerald I: 5 articles (04/2011 - 12/2002)|
|8.||Baserga, Renato: 5 articles (08/2009 - 03/2007)|
|9.||Kubota, Naoto: 5 articles (03/2009 - 06/2003)|
|10.||Kadowaki, T: 5 articles (11/2008 - 01/2000)|
07/01/2015 - "The decrease of miR-183 expression promotes protection against insulin resistance by increasing insulin receptor substrate 1 (IRS1) levels. "
03/01/2007 - "Clearance of HCV improves insulin resistance, beta-cell function, and hepatic expression of insulin receptor substrate 1 and 2."
08/20/2015 - "Impairment of insulin receptor substrate 1 signaling by insulin resistance inhibits neurite outgrowth and aggravates neuronal cell death."
07/01/2015 - "The Arg972 insulin receptor substrate-1 (IRS-1) is associated with insulin resistance. "
10/08/2014 - "Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1 (S307)) is a hallmark of insulin resistance. "
09/01/2009 - "The aim of this study was to test tolerability and efficacy of gene signal (GS)-101 eye drops, an antisense oligonucleotide against insulin receptor substrate-1, versus placebo on inhibition of progressive corneal neovascularization. "
09/01/2014 - "Eye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-1 expression, inhibited corneal neovascularization in a previous dose-finding phase II study. "
10/01/2013 - "Neuronal overexpression of insulin receptor substrate 2 leads to increased fat mass, insulin resistance, and glucose intolerance during aging."
05/01/2015 - "This study aimed to measure the hepatic expression of insulin receptor substrate-2 (IRS-2) and glucose transporter-2 (GLUT-2) in type 2 diabetic rats post-DJE, and to investigate their roles in improved hepatic insulin resistance and glucose intolerance. "
07/01/2003 - "In order to understand the role of the insulin receptor substrate-2 (IRS2) gene (chromosome region: 13q34) in obesity, a complex disorder associated with insulin resistance and glucose intolerance, we determined single nucleotide polymorphims (SNPs) and complex haplotypes in women with morbid obesity and a body mass index (BMI) of 41+/-0.8 kg/m2 ( n=99) compared with controls having a BMI of 23.8+/-0.1 kg/m2 ( n=92). "
04/01/2007 - "At the same time, the HS-induced glucose intolerance, impaired postprandial glycemic control, and decrease in muscle and liver insulin-induced activation of insulin receptor substrate 1 and Akt were prevented by increasing the level of dietary cysteine, a major original finding. "
12/01/2010 - "Remarkably, disruption of Alox15 attenuated glucose intolerance and high-fat diet-induced insulin resistance, up-regulated insulin receptor substrate-2, and exerted opposite effects on hepatic c-Jun amino-terminal kinase and adenosine monophosphate-activated protein kinase phosphorylation, known negative and positive regulators of insulin signaling, respectively. "
|4.||Muscular Atrophy (Muscle Atrophy)
12/01/2012 - "Under muscle atrophy conditions, Cbl-b interacted with and degraded IRS-1 (insulin receptor substrate 1) that is a central molecule in the IGF-1 signaling pathway. "
02/01/2006 - "This study tested the hypothesis that an isometric resistance training paradigm targeting the medial gastrocnemius of adult rodents is effective in preventing muscle atrophy during the early stages of hindlimb unloading by maintaining normal activation of the insulin receptor substrate-1 (IRS-1)/phosphoinositide-3 kinase (PI3K)/Akt signaling pathway. "
04/01/2013 - "C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy."
04/01/2014 - "The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich mRNA stability by reducing 14-3-3β-tristetraprolin protein complex, reducing inflammation and psoriatic lesion size in patients."
03/01/2010 - "In summary, we show that, in a rodent model of T2DM, voluntary exercise decreases circulating markers of inflammation and oxidative stress and lowers hepatic JNK activation and Ser(307)-phosphorylated insulin receptor substrate-1. "
07/01/2009 - "The 8-OhdG immunolocalization in liver tissues of the group 4 obviously decreased compared with those of groups 2 and 3. For Western blotting, the expressions of insulin receptor substrate-1 (IRS-1) and phosphorylated IRS-1 (pIRS-1) in liver tissues of group 4 increased compared with those of groups 2 and 3. On the other hand, the expressions of pAkt, pIKKbeta and pNF-kappaB decreased compared with those of groups 2 and 3. From these results, EGCG reduces inflammation, insulin resistance and oxidative stress, and suppresses liver injury in nSREBP-1c transgenic mice."
09/01/2014 - "Nuclear factor kappa B (NFκB), tumor necrosis factor alpha (TNFα) and the level of inhibitory phosphorylation of insulin receptor substrate-1 (IRS-1) on Ser(307) were analyzed as markers of hepatic inflammation. "
12/01/2012 - "Importantly, treatment of adipocytes with the supernatant of activated Y1-deficient macrophages causes insulin resistance, as demonstrated by decreased insulin-induced phosphorylation of the insulin receptor and Akt as well as decreased expression of insulin receptor substrate 1. Thus, Y1 signaling in hematopoietic-derived cells such as macrophages is critical for the control of inflammation and insulin resistance in obesity."
|3.||Interleukin-6 (Interleukin 6)
|5.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|6.||Insulin Receptor Substrate Proteins
|9.||Ophthalmic Solutions (Eye Drops)
|10.||Facilitative Glucose Transport Proteins (Glucose Transporter)
|4.||Gastric Bypass (Roux-en-Y Gastric Bypass)
|5.||Heterologous Transplantation (Xenotransplantation)