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Macrophage Activation Syndrome

A serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T-LYMPHOCYTES and MACROPHAGES. It is seen predominantly in children with systemic onset JUVENILE IDIOPATHIC ARTHRITIS.
Also Known As:
Syndrome, Macrophage Activation
Networked: 150 relevant articles (14 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
2. Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome)
3. Adult-Onset Still's Disease
4. Systemic Lupus Erythematosus (Libman-Sacks Disease)
5. Arthritis (Polyarthritis)

Experts

1. Grom, Alexei A: 7 articles (01/2016 - 09/2003)
2. Martini, Alberto: 5 articles (01/2016 - 12/2012)
3. Yokota, Shumpei: 5 articles (04/2015 - 01/2004)
4. Yachie, Akihiro: 4 articles (10/2015 - 09/2010)
5. Shimizu, Masaki: 4 articles (10/2015 - 09/2010)
6. Wouters, Carine: 4 articles (08/2015 - 02/2005)
7. Cron, Randy Q: 4 articles (01/2014 - 02/2011)
8. Dinarello, Charles A: 4 articles (12/2013 - 11/2005)
9. Brunner, Hermine I: 3 articles (01/2016 - 03/2007)
10. Ilowite, Norman T: 3 articles (01/2016 - 03/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Macrophage Activation Syndrome:
1. Cyclosporine (Ciclosporin)FDA LinkGeneric
2. Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
3. Adrenal Cortex Hormones (Corticosteroids)IBA
4. canakinumabFDA Link
5. TNFR-Fc fusion protein (etanercept)FDA Link
6. tocilizumabFDA Link
7. CytokinesIBA
8. Interleukin-1 (Interleukin 1)IBA
9. infliximab (Remicade)FDA Link
10. Biological Markers (Surrogate Marker)IBA

Therapies and Procedures

1. Splenectomy
2. Stem Cell Transplantation
3. Intensive Care (Surgical Intensive Care)
4. Liver Transplantation
5. Plasmapheresis