Catheter-Related Infections

Infections resulting from the use of catheters. Proper aseptic technique, site of catheter placement, material composition, and virulence of the organism are all factors that can influence possible infection.

Also Known As:

Catheter-Associated Infections; Associated Infection, Catheter; Associated Infections, Catheter; Catheter Associated Infections; Catheter Related Infections; Catheter-Associated Infection; Catheter-Related Infection; Infection, Catheter Associated; Infection, Catheter Related; Infection, Catheter-Associated; Infection, Catheter-Related; Infections, Catheter Associated; Infections, Catheter Related; Infections, Catheter-Associated; Infections, Catheter-Related; Related Infection, Catheter; Related Infections, Catheter; Catheter Associated Infection; Catheter Related Infection

Networked: 1313 relevant articles (89 outcomes, 134 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Catheter-Related Infections: 1313

Related Diseases

1.	Infections
2.	Sepsis (Septicemia)
3.	Bacteremia
4.	Neoplasms (Cancer)
5.	Critical Illness (Critically Ill)

Experts

1.	Timsit, Jean-François: 22 articles (01/2022 - 10/2007)
2.	Mimoz, Olivier: 16 articles (01/2022 - 10/2007)
3.	Lucet, Jean-Christophe: 16 articles (10/2021 - 03/2009)
4.	Souweine, Bertrand: 14 articles (01/2022 - 10/2009)
5.	Parienti, Jean-Jacques: 12 articles (01/2022 - 03/2004)
6.	Ruckly, Stéphane: 12 articles (01/2022 - 06/2012)
7.	Buetti, Niccolò: 9 articles (01/2022 - 12/2019)
8.	Mermel, Leonard A: 9 articles (01/2022 - 06/2002)
9.	Bouadma, Lila: 9 articles (01/2021 - 03/2009)
10.	Lok, Charmaine E: 9 articles (07/2016 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Catheter-Related Infections:

1.	Anti-Bacterial Agents (Antibiotics)IBA 11/01/1997 - "Seven patients with catheter-related infections were treated successfully with intraventricular and systemic antibiotic drugs, thereby preserving the Ommaya system. " 10/30/2015 - "Our objective was to evaluate the efficacy of different antibiotic combinations using an in vitro model of catheter-related infection. " 12/22/2021 - "Future studies are needed to establish whether such lock solutions can be used to render peritoneal catheter-related infections more susceptible to antibiotic treatment. " 05/01/2016 - "We did a study to examine the effect of an alternating topical antibiotic regimen in preventing catheter-related infection. " 08/01/2008 - "A total of three studies were found which addressed the role of prophylactic antibiotics to prevent catheter-related infection in neonates. "
2.	ChlorhexidineIBA 01/01/2002 - "Other clinical studies also reported catheter-associated infections with chlorhexidine- and multidrug-resistant strains of Pr. " 01/01/2002 - "Other clinical studies also reported catheter-associated infections with chlorhexidine- and multidrug-resistant strains of Pr. " 09/07/2020 - "Recommendations regarding catheter-related infections' prevention included the preferential use of subclavian central vein (GRADE 1), a one-step skin disinfection(GRADE 1) using 2% chlorhexidine (CHG)-alcohol (GRADE 1), and the implementation of a quality of care improvement program. " 10/01/2009 - "The introduction of chlorhexidine was followed by a profound, sustained fall in catheter-related infections. " 07/22/2009 - "Chlorhexidine-impregnated sponges and prevention of catheter-related infections."
3.	Heparin (Liquaemin)FDA LinkGeneric 11/01/2001 - "Clinical trials using new materials such as covalently linked heparin on the CVC surface, electrically charged CVC, novel topical agents that interfere with bacterial colonization, antiadhesin molecules and agents that block the gene expression involved in the biofilm formation, are all needed to reduce the high catheter-related infection risk among HIV+ patients." 12/01/2011 - "Infection control records revealed two periods of increased catheter-related infections, corresponding with two intervals when preservative-free heparin was used at SJCRH. " 12/01/2011 - "There is little published evidence regarding whether heparin lock solutions containing preservatives prevent catheter-related infections. " 07/01/2016 - "However, whether a low-dose lock is superior to a high-dose heparin lock in preventing catheter-related infections and maintaining catheter patency is inconclusive. " 02/01/2015 - "Initial heparin locks instilled after tunnelled dialysis catheter (TDC) insertion can leak causing systemic anticoagulation and also promote staphyloccocal biofilm formation, predisposing to catheter-related infection (CRI). "
4.	SilverIBA 11/01/1998 - "In conclusion, our study does not show any benefit of the silver ring in preventing catheter-related infections in PD patients. " 07/01/1996 - "Previous studies have shown that silver formulations coated onto implantable materials retard bacterial colonization and reduce the incidence of catheter-related infections. " 07/01/1999 - "Silver coating of medical devices for catheter-associated infections?" 11/01/1998 - "To establish whether a silver ring device (designed by Grosse-Siestrup in 1992) mounted onto the PD catheter and placed at the exit site at skin level is effective in preventing exit-site and other catheter-related infections, a prospective 12-month, multicenter, controlled study stratified by diabetes status was conducted. " 12/01/1995 - "We conclude that this new silver-coated central venous catheter is biocompatible and effective in reducing the incidence of catheter-related infections in oncological patients."
5.	Rifampin (Rifampicin)FDA LinkGeneric 01/01/1993 - "epidermidis catheter-associated infections using rifampin.(ABSTRACT TRUNCATED AT 250 WORDS)" 08/01/1991 - "The catheter-related infection rate in rifampin-treated patients was .26 per patient-year versus .93 per patient-year in untreated patients. " 08/01/1991 - "We conclude that intermittent rifampin administration is effective in decreasing catheter-related infections in a peritoneal dialysis population." 09/01/2010 - "Rifampicin-based impregnated catheters seem to be better for prevention of catheter-related infection compared with the other catheters." 08/01/1991 - "The rifampin-treated patients had a significant delay in time to first catheter-related infection (P less than 0.015) and significantly fewer catheter-related infections overall (P less than 0.001). "
6.	SolutionsIBA 10/01/1988 - "We conducted a pilot study to examine the effects of three protocols on catheter-related infection: group I, change of flush solution and pressure monitoring tubing every 24 hours; group II, change of flush solution every 24 hours and change of pressure monitoring tubing every 48 hours; group III, change of flush solution and pressure monitoring tubing every 48 hours. " 10/01/1988 - "The optimal frequency for changing pressure monitoring tubing and flush solution that minimizes catheter-related infection and contains cost has not yet been established. " 06/09/2021 - "These findings propound that SNACET lock solution is a promising biocidal agent and demonstrate the initiation of a new platform technology for NO-releasing lock solution therapy for the inhibition and treatment of catheter-related infections." 01/01/1999 - "These data suggest that AgCl-BKC coated catheters may provide another solution for reduction of catheter-related infections." 04/01/2017 - "Does antimicrobial lock solution reduce catheter-related infections in hemodialysis patients with central venous catheters? "
7.	Ethanol (Ethyl Alcohol)IBA 05/01/2015 - "Clinical studies of ethanol lock to prevent catheter-related infections (CRIs) suggest preventive efficacy. " 11/15/2013 - "Ethanol lock is an emerging therapeutic option for preventing and/or controlling catheter-associated infection. " 10/01/2006 - "Patients Forty children with diverse underlying disorders were treated for 51 catheter-related infections using the Childrens Hospital Los Angeles ethanol-lock technique. " 01/01/2019 - "Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials." 03/01/2023 - "It was shown in the literature that ethanol locks have a positive effect on preventing catheter-related infections in patients with central venous catheters without causing any microbial resistance. "
8.	Local Anti-Infective Agents (Antiseptics)IBA 01/01/2021 - "No catheter-related infections or adverse effects of antiseptic solutions were observed in either group. " 01/01/2021 - "The secondary endpoints were the incidence of catheter-related infections and the adverse effects of the antiseptic solutions. " 09/01/2016 - "Compare the effectiveness of different cutaneous antiseptics in reducing risk of catheter-related infection in intensive care unit (ICU) patients. " 12/01/1993 - "Prevention of catheter-related infections by antiseptic bonding." 06/01/2010 - "[Prevention of catheter-related infection: usefulness and cost-effectiveness of antiseptic catheters in children]."
9.	Citric Acid (Citrate)FDA LinkGeneric 01/01/2023 - "Catheter-related infections and adverse events were less frequent with citrate locks, but reached statistical significance in only two studies. " 10/01/2019 - "Effects of prophylactic use of taurolidine-citrate lock on the number of catheter-related infections in children under 2 years of age undergoing surgery." 03/01/2014 - "An antimicrobial-containing citrate lock is better than a heparin lock in the prevention of catheter-related infection, while citrate alone fails to show a similar advantage. " 06/01/2002 - "These findings suggest that taurolidine-citrate is a promising combination agent for the prevention and treatment of intravascular catheter-related infections." 03/01/2014 - "However, whether a citrate lock is superior to a heparin lock in preventing catheter-related infections and maintaining catheter patency is inconclusive. "
10.	Silver Sulfadiazine (SSD)FDA LinkGeneric 06/01/2017 - "Objective The efficacy of chlorhexidine- and silver sulfadiazine-coated central venous catheters (CSS-CVC) against catheter-related infection remains controversial. " 06/01/2017 - "Chlorhexidine and silver sulfadiazine coating on central venous catheters is not sufficient for protection against catheter-related infection: Simulation-based laboratory research with clinical validation." 04/01/2005 - "Reduction of catheter-related infections in neutropenic patients: a prospective controlled randomized trial using a chlorhexidine and silver sulfadiazine-impregnated central venous catheter." 03/01/2003 - "We assessed the methodological trial quality of individual randomized controlled studies on chlorhexidine silver sulfadiazine impregnated catheters and the effect on catheter-related infection (CRI). " 10/01/1996 - "Phase 2: The rate of catheter-related infection was determined for a trial group of triple-lumen catheters impregnated with silver sulfadiazine and chlorhexidine. "

Therapies and Procedures

1.	Catheters 01/01/2019 - "In catheter-related infections, sometimes it is possible to provide antimicrobial treatment without removal of catheter with good results, as in our patient. " 09/01/2000 - "The data indicate that the use of the new catheter hub device is no more effective in preventing catheter-related infection than standard good clinical procedures." 04/01/1991 - "In patients with suspected catheter-related infection whose peripheral blood cultures do not grow the same organism as a blood culture drawn from the catheter, a guidewire exchange of the catheter has been shown to be effective. " 11/14/2023 - "These findings are helpful for the treatment of biofilm-associated catheter contamination, which allows an increase in the catheter wearing time without frequent replacement and treatment of catheter-associated infections." 07/25/2013 - "To assess the efficacy of antimicrobial-impregnated catheters in preventing catheter-related infections during external ventricular drainage (EVD), we performed a meta-analysis and systematic review. "
2.	Central Venous Catheters 08/01/1998 - "To evaluate the efficacy of tunneling short-term central venous catheters to prevent catheter-related infections. " 04/01/2017 - "Cumulative Evidence of Randomized Controlled and Observational Studies on Catheter-Related Infection Risk of Central Venous Catheter Insertion Site in ICU Patients: A Pairwise and Network Meta-Analysis." 08/15/2014 - "This prospective randomized controlled study with 975 nontunneled central venous catheters (CVCs) showed that the semiquantitative roll-plate culture technique (SQC) was as accurate as the sonication method for diagnosis of catheter-related infections. " 09/01/2010 - "We identified randomised, controlled trials that compared different types of central venous catheter (CVC), evaluating catheter-related infections in a systematic search of articles published from January 1996 to November 2009 via Medline, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials. " 12/01/2007 - "The primary aim of this study was to compare catheter-associated infections and tip contaminations between percutaneously placed central venous catheters in the internal jugular and subclavian veins in surgical neonates undergoing major noncardiac surgery. "
3.	Renal Dialysis (Hemodialysis) 04/01/2017 - "The purpose of our study is to carry out a Bayesian network meta-analysis comparing the efficacy of different antimicrobial lock solutions (ALS) for prevention of catheter-related infections (CRI) in patients with hemodialysis (HD) and ranking these ALS for practical consideration. " 10/01/2003 - "The LifeSite Hemodialysis Access System was recently introduced as a completely subcutaneous device with reported advantages of improved patient comfort and reduced catheter-related infection. " 01/01/2023 - "Background: Catheter-related infection (CRI) is a major complication in patients undergoing hemodialysis. " 11/29/2022 - "Catheter-related infections (CRI) are a major cause of morbidity and mortality in chronic hemodialysis (HD) patients. " 11/29/2022 - "Incidence and challenges in management of hemodialysis catheter-related infections."
4.	Therapeutics 10/24/2008 - "Transthoracic and transesophageal echocardiography has been proved efficient and cost-effective in guiding therapy in cases of catheter related infections. " 09/01/2019 - "Potential efficacy of garlic lock therapy in combating biofilm and catheter-associated infections; experimental studies on an animal model with focus on toxicological aspects." 11/01/1998 - "All eligible patients (n=195) from the study area without catheter-related infections during the ascertainment period were included (incidental subjects undergoing PD therapy for at least 3 months). " 05/15/1984 - "Finally, all studies failed to demonstrate the ability of systemic antimicrobial therapy to eradicate catheter-associated infections other than temporarily. " 03/01/2022 - "Often associated to the colonization by Candida spp. biofilm, the catheter-related infections are a serious health problem since the absence of a specific therapy. "
5.	Drug Therapy (Chemotherapy) 07/01/2013 - "The catheter related infection caused by Staphylococcus epidermidis biofilm is increasing and difficult to treat by antimicrobial chemotherapy. " 04/01/2002 - "Less frequent catheter dressing changes decrease local cutaneous toxicity of high-dose chemotherapy in children, without increasing the rate of catheter-related infections: results of a randomised trial." 10/01/2008 - "Catheter-related infections and associated risk factors in 392 patients participating in a randomized adjuvant breast cancer trial and assigned to receive high-dose chemotherapy and peripheral stem-cell reinfusion were evaluated. " 01/01/2018 - "Factor analysis of variance showed that many factors were related to PICC catheter-related infections, including experience of operator (χ2 = 3.48, P < 0.05), catheter retention time (χ2 = 7.478, P < 0.05), receiving chemotherapy or not (χ2 = 2.43, P < 0.05), Karnofsky Performance Scale scores (χ2 = 2.19, P < 0.05) and the frequency of replacing pad pasting on the point of puncture (χ2 = 2.23). " 08/01/2014 - "After chemotherapy, he contracted a catheter-related infection with a high fever up to 41℃ leading to monomorphic VT. "