Growth Differentiation Factor 15

A growth differentiation factor that is secreted in response to cell stress and in response to MACROPHAGE ACTIVATION. In addition growth differentiation factor 15 demonstrates a diverse array of biological properties including the induction of cartilage formation, the inhibition of hematopoietic progenitor proliferation, and the induction of neuronal migration.

Also Known As:

Networked: 1050 relevant articles (32 outcomes, 215 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wollert, Kai C: 38 articles (11/2019 - 02/2006)
2.	Kempf, Tibor: 37 articles (03/2017 - 02/2006)
3.	Wallentin, Lars: 32 articles (06/2022 - 02/2007)
4.	Siegbahn, Agneta: 27 articles (06/2022 - 10/2007)
5.	Breit, Samuel N: 18 articles (12/2019 - 03/2003)
6.	Brown, David A: 17 articles (12/2019 - 03/2003)
7.	Li, Yan: 10 articles (10/2022 - 02/2013)
8.	James, Stefan K: 10 articles (06/2022 - 01/2014)
9.	Storey, Robert F: 10 articles (06/2022 - 01/2014)
10.	Lichtenauer, Michael: 10 articles (02/2022 - 09/2017)

Related Diseases

1.	Hemorrhage 01/01/2023 - "The addition of GDF-15 to the HAS-BLED score significantly improved discrimination and calibration for predicting major bleeding [C-statistics increased from 0.61 (95% CI 0.52-0.70) to 0.68 (95% CI 0.61-0.78)]. " 04/21/2016 - "The ITALIC! C-statistic improved for the prediction of CV death and non-CABG-related major bleeding when adding GDF-15 to established risk factors. " 08/01/2017 - "GDF-15 improved the c index of both the HAS-BLED (0.62-0.69) and ORBIT (0.68-0.71) bleeding risk scores. " 01/01/2021 - "Overall, the association between GDF-15, the ABC-AF-bleeding score and ABC-AF-death risk score with major bleeding and death was consistent across regions in both ARISTOTLE and the RE-LY trial cohorts. " 01/01/2021 - "GDF-15 and the ABC-AF-bleeding score were associated with major bleeding in both trials across regions (p<0.0001). "
2.	Obesity 01/01/2021 - "Growth differentiation factor 15 as a potential therapeutic for treating obesity." 01/01/2022 - "Growth/differentiation factor 15 (GDF15) has emerged as a potential therapeutic target in obesity treatment. " 01/01/2022 - "In addition, we perform exploratory correlations of total and intact GDF-15 with clinical, hormonal and metabolo-lipidomic parameters in humans with obesity. " 12/01/2021 - "GDF-15 has anti-inflammatory, anti-oxidative stress and anti-apoptotic effect in DM and obesity via targeting NF-κB mechanisms." 01/01/2021 - "Growth differentiation factor 15 (GDF15) is closely related to obesity. "
3.	Myocardial Infarction 02/28/2023 - "Aim    To study the role of growth differentiation factor 15 (GDF-15) in the long-term prognosis for patients after uncomplicated myocardial infarction (MI).Material and methods    This study included 118 MI patients aged &lt;70 years with and without ST-segment elevation on electrocardiogram (ECG). " 04/01/2022 - "Recent studies suggest that GDF-15 is elevated in patients with acute myocardial infarction (AMI), but the prognostic remains incompletely defined. " 01/01/2022 - "This study aims to evaluate the association of serum growth differentiation factor 15 (GDF-15) with in-hospital mortality and arrhythmic risks in patients with acute myocardial infarction (AMI). " 05/31/2021 - "Aim    To analyze associations between levels of the inflammatory marker, growth differentiation factor 15 (GDF-15), and echocardiographic indexes in CHF patients with mid-range and preserved left ventricular ejection fraction (LV EF) depending on the history of myocardial infarction (MI).Material and methods    This study included 34 CHF patients with preserved and mid-range LV EF after MI (group 1, n=19) and without a history of MI (group 2, n=15). " 10/01/2018 - "This study sought to identify the clinical value of repeated measurement of GDF-15 in Chinese Han patients with post-myocardial infarction CHF. "
4.	Weight Loss (Weight Reduction) 01/20/2023 - "This study suggests that GDF-15 may be one of the molecules mediating the link between PA and late-life weight loss, but mechanistic studies are necessary to further support the present findings." 10/07/2023 - "Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over four years. " 01/01/2016 - "Although GDF-15 has been reported to be involved in energy homoeostasis and weight loss, to have anti-inflammatory properties, and to predict CV diseases and CV events in general or established CV disease population, there is no large of body of evidence regarding predictive role of elevated GDF-15 in T2DM subjects. " 01/01/2019 - "Growth differentiation factor 15 (GDF15) has shown promise as a weight loss agent for obesity in animal studies. " 11/26/2023 - "gondii infection caused a significant weight loss that is preceded by elevation of serum levels of IFN-γ and GDF-15. "
5.	Body Weight (Weight, Body) 01/01/2022 - "Higher rises of circulating GDF-15 associated with more loss of body weight and visceral fat. " 12/31/2020 - "No difference was found in GDF-15 between CP with low muscle mass and those with moderate/high muscularity and between patients with body weight loss and those with stable weight. " 10/15/2019 - "GDF-15 was not correlated with clinical features in LE or BMI or body weight in ALS. " 03/01/2019 - "Growth differentiation factor 15 (GDF15) is a key regulator of body weight in animals by regulating food intake. " 10/01/2017 - "Growth differentiation factor 15 (GDF15; also known as MIC-1) is a divergent member of the TGF-β superfamily and is associated with body-weight regulation in humans and rodents. "

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6.	C-Reactive Protein
7.	Troponin T (Troponin T1)
8.	Brain Natriuretic Peptide (Natrecor)
9.	Hepcidins
10.	Intercellular Signaling Peptides and Proteins (Growth Factors)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Fontan Procedure (Fontan Operation)
4.	Gastric Bypass (Roux-en-Y Gastric Bypass)
5.	Patient Readmission