HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

Growth Differentiation Factor 6

A growth differentiation factor that plays a role in the neural differentiation, specifically in the retinal development of the EYE.

Also Known As:

GDF-6

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - TGF-beta Superfamily Proteins: 1
      - Growth Differentiation Factors: 22
        Growth Differentiation Factor 6: 5
        human GDF6 protein
        mouse Gdf6 protein
        rat Gdf6 protein
        zebrafish gdf6a protein
        zebrafish GDF6B protein
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - TGF-beta Superfamily Proteins: 1
      - Growth Differentiation Factors: 22
        Growth Differentiation Factor 6: 5
        human GDF6 protein
        mouse Gdf6 protein
        rat Gdf6 protein
        zebrafish gdf6a protein
        zebrafish GDF6B protein
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - TGF-beta Superfamily Proteins: 1
    - Growth Differentiation Factors: 22
      - Growth Differentiation Factor 6: 5
        human GDF6 protein
        mouse Gdf6 protein
        rat Gdf6 protein
        zebrafish gdf6a protein
        zebrafish GDF6B protein

Experts

1.	Bhatnagar, Sanchita: 1 article (01/2018)
2.	Ceol, Craig J: 1 article (01/2018)
3.	Chhangawala, Sagar: 1 article (01/2018)
4.	Deng, April: 1 article (01/2018)
5.	Dresser, Karen: 1 article (01/2018)
6.	Edwards, Yvonne J K: 1 article (01/2018)
7.	Gomes, Camilla Borges Ferreira: 1 article (01/2018)
8.	Gramann, Alec K: 1 article (01/2018)
9.	Green, Michael: 1 article (01/2018)
10.	Gujja, Sharvari: 1 article (01/2018)

Related Diseases

1.	Choroidal Neovascularization 01/01/2017 - "The purpose of this study was to evaluate the expression of high-temperature requirement A serine peptidase 1 (HTRA1), TGF-β1, bone morphogenetic protein 4 (BMP4), growth differentiation factor 6 (GDF6), and VEGFA proteins in the aqueous humor of patients with naïve choroidal neovascularization (nCNV) secondary to AMD. "
2.	Leber Congenital Amaurosis 04/01/2013 - "Here we show that mutations in the transforming growth factor-β (TGF-β) ligand Growth Differentiation Factor 6, which specifies the dorso-ventral retinal axis, contribute to Leber congenital amaurosis. "
3.	Melanoma (Melanoma, Malignant) 01/01/2018 - "We determined that the gene encoding growth differentiation factor 6 (GDF6), which is the ligand for the BMP family, is recurrently amplified and transcriptionally upregulated in melanoma. "
4.	Macular Degeneration (Age-Related Maculopathy) 11/22/2014 - "Growth differentiation factor 6 (GDF6) has been reported to be a novel disease gene for age-related macular degeneration (AMD) in Caucasians. "
5.	Anophthalmos (Anophthalmia) 12/18/2010 - "A few genes (orthodenticle homeobox 2 [OTX2], retina and anterior neural fold homeobox [RAX], SRY-box 2 [SOX2], CEH10 homeodomain-containing homolog [CHX10], and growth differentiation factor 6 [GDF6]) have been implicated mainly in isolated micro/anophthalmia but causative mutations of these genes explain less than a quarter of these developmental defects. "

Related Drugs and Biologics

1.	Bone Morphogenetic Protein 4
2.	Proteins (Proteins, Gene)
3.	High-Temperature Requirement A Serine Peptidase 1
4.	Ligands
5.	Transforming Growth Factors (Transforming Growth Factor)
6.	Retinaldehyde (Retinal)