Bone Morphogenetic Protein 5

A bone morphogenetic protein that may play a role in CARTILAGE formation. It is a potent regulator of the growth of CHONDROCYTES and the synthesis of cartilage matrix proteins. Evidence for its role in cartilage formation can be seen in MICE, where genetic mutations that cause loss of bone morphogenetic protein 5 function result in the formation of small malformed ears.

Also Known As:

Networked: 23 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Ping: 1 article (12/2021)
2.	DiSanto, Michael E: 1 article (12/2021)
3.	Fu, Xun: 1 article (12/2021)
4.	Hassan, Hassan M: 1 article (12/2021)
5.	He, Weixiang: 1 article (12/2021)
6.	Li, Mingzhou: 1 article (12/2021)
7.	Li, Yan: 1 article (12/2021)
8.	Liu, Daoquan: 1 article (12/2021)
9.	Liu, Huan: 1 article (12/2021)
10.	Liu, Jianmin: 1 article (12/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2018 - "Using bioinformatics, we identified Bone morphogenetic protein 5 (BMP5) is a direct target of miR-32, and loss of tumor suppressor BMP5 may partially due to the miR-32 dysregulation. " 08/01/2001 - "BMP-5 and -6 were prominent in the cytoplasm of tumor cells, and they stained weakly in osteoblast-like cells adjacent to newly formed bone. " 01/21/2020 - "Cumulative studies have provided controversial evidence for the prognostic values of bone morphogenetic protein 5 (BMP5) in different types of cancers such as colon, breast, lung, bladder, and ovarian cancer. " 02/10/2020 - "We found that LHX2, BMP-5 and GDF11 had complex interactions with other missing proteins and BMP-5 had both tumor suppressing and tumorigenic roles. " 01/21/2020 - "A Multi-Omics Analysis of Bone Morphogenetic Protein 5 (BMP5) mRNA Expression and Clinical Prognostic Outcomes in Different Cancers Using Bioinformatics Approaches."
2.	Knee Osteoarthritis 12/01/2014 - "The aim of this study was to investigate associations between single nucleotide polymorphisms rs13301537 in asporin (ASPN) and rs373444 in the bone morphogenetic protein 5 (BMP5) gene with knee osteoarthritis (OA) susceptibility in a Chinese Han population. "
3.	Hip Osteoarthritis (Coxarthrosis) 12/19/2009 - "In a previous study carried out by our group, the genotyping of 36 microsatellite markers from within a narrow interval of chromosome 6p12.3-q13 generated evidence for linkage and for association to female hip osteoarthritis (OA), with the most compelling association found for a marker within intron 1 of the bone morphogenetic protein 5 gene (BMP5). "
4.	Ovarian Neoplasms (Ovarian Cancer) 01/21/2020 - "Cumulative studies have provided controversial evidence for the prognostic values of bone morphogenetic protein 5 (BMP5) in different types of cancers such as colon, breast, lung, bladder, and ovarian cancer. "
5.	Otosclerosis 06/01/2012 - "This study is the first to establish that bone morphogenetic protein 5 (BMP5) plays a role in the pathogenesis of otosclerosis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Bone Morphogenetic Protein 7
3.	Cytokines
4.	Messenger RNA (mRNA)
5.	Bone Morphogenetic Protein 6
6.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
7.	Type II Bone Morphogenetic Protein Receptors (Bone Morphogenetic Protein Receptor Type II)
8.	Bone Morphogenetic Protein Receptors
9.	Intercellular Signaling Peptides and Proteins (Growth Factors)
10.	Tissue Inhibitor of Metalloproteinase-2