Growth Differentiation Factors

A family of BONE MORPHOGENETIC PROTEIN-related proteins that are primarily involved in regulation of CELL DIFFERENTIATION.

Also Known As:

Differentiation Factors, Growth; Factors, Growth Differentiation

Networked: 22 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - TGF-beta Superfamily Proteins: 1
      - Growth Differentiation Factors: 22
        Myostatin: 1229
        Growth Differentiation Factor 15: 1050
        Growth Differentiation Factor 2: 97
        Growth Differentiation Factor 5: 96
        Growth Differentiation Factor 9: 56
        Bone Morphogenetic Protein 15: 44
        Growth Differentiation Factor 3: 11
        Growth Differentiation Factor 10: 10
        Growth Differentiation Factor 1: 7
        Growth Differentiation Factor 6: 5
        mouse Gdf7 protein: 1
        human GDF11 protein
        human GDF7 protein
        mouse Gdf11 protein
        rat Gdf11 protein
        rat Gdf7 protein
        Xenopus GDF7 protein
        zebrafish GDF11 protein
        zebrafish gdf7 protein
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - TGF-beta Superfamily Proteins: 1
      - Growth Differentiation Factors: 22
        Myostatin: 1229
        Growth Differentiation Factor 15: 1050
        Growth Differentiation Factor 2: 97
        Growth Differentiation Factor 5: 96
        Growth Differentiation Factor 9: 56
        Bone Morphogenetic Protein 15: 44
        Growth Differentiation Factor 3: 11
        Growth Differentiation Factor 10: 10
        Growth Differentiation Factor 1: 7
        Growth Differentiation Factor 6: 5
        mouse Gdf7 protein: 1
        human GDF11 protein
        human GDF7 protein
        mouse Gdf11 protein
        rat Gdf11 protein
        rat Gdf7 protein
        Xenopus GDF7 protein
        zebrafish GDF11 protein
        zebrafish gdf7 protein
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - TGF-beta Superfamily Proteins: 1
    - Growth Differentiation Factors: 22

Experts

1.	Fang, Cong: 2 articles (11/2012 - 08/2011)
2.	Alexander, Mark J: 1 article (12/2022)
3.	Andre, Patrick: 1 article (12/2022)
4.	Belcheva, Elitza: 1 article (12/2022)
5.	Bloom, Troy: 1 article (12/2022)
6.	Briscoe, Steven D: 1 article (12/2022)
7.	Castonguay, Roselyne: 1 article (12/2022)
8.	Frost, Jeffrey L: 1 article (12/2022)
9.	Grenha, Rosa: 1 article (12/2022)
10.	Herrin, Brantley R: 1 article (12/2022)

Related Diseases

1.	Glioma (Gliomas) 01/16/2004 - "In this study, the appican CS chain from rat C6 glioma cells was shown to specifically bind several growth/differentiation factors including midkine (MK) and pleiotrophin (PTN). "
2.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/01/2022 - "The oocyte-secreted factors growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) play essential roles in follicle development and oocyte maturation, and aberrant regulation might contribute to the pathogenesis of polycystic ovary syndrome. " 11/01/2012 - "To investigate the expression pattern and significance of two important oocyte-secreted factors: growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) during oocyte maturation in women with polycystic ovary syndrome (PCOS) and infertile women due to husband factors. " 08/01/2011 - "To investigate the expression pattern of two oocyte-secreted factors-growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BM15)-during oocyte maturation in women with polycystic ovary syndrome (PCOS) and in controls and to evaluate the expression differences in oocytes between the two groups. "
3.	Neoplasms (Cancer) 03/01/2012 - "There has been a recent surge of interest in the role of growth differentiation factors and other BMPs in the development and spread of cancer. " 07/01/2007 - "There has been a recent surge of interest in the role of growth differentiation factors and other bone morphogenic proteins in the development and spread of cancer. " 01/01/2019 - "Growth differentiation factors (GDFs) are a subfamily of proteins belonging to the transforming growth factor beta superfamily that have functions predominantly in tissue development and cancer. "
4.	Heart Failure 01/01/2023 - "Prognostic value of Growth differentiation factors 15 in Acute heart failure patients with preserved ejection fraction." 10/01/2019 - "Plasma growth differentiation factors 8 and 11 levels in cats with congestive heart failure secondary to hypertrophic cardiomyopathy." 08/25/2023 - "Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-like-3, and Risk of Heart Failure in Elders."
5.	Pulmonary Arterial Hypertension 07/01/2023 - "Is sotatercept, which traps activins and growth differentiation factors, a new dawn in treating pulmonary arterial hypertension (PAH)?" 04/20/2023 - "Sotatercept is a fusion protein that traps activins and growth differentiation factors involved in pulmonary arterial hypertension. " 12/01/2022 - "Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial hypertension (PAH) by selectively trapping activins and growth differentiation factors. "

Related Drugs and Biologics

1.	Midkine
2.	appican
3.	pleiotrophin (HARP)
4.	Proteins (Proteins, Gene)
5.	Bone Morphogenetic Protein 15
6.	Activins (Activin)
7.	Factor IX (Coagulation Factor IX)
8.	ACE-011
9.	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)
10.	Enzymes