Acute Lung Injury

A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).

Also Known As:

Networked: 10257 relevant articles (938 outcomes, 1652 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sepsis (Septicemia)
2.	Inflammation (Inflammations)
3.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
4.	Pulmonary Edema
5.	Lung Injury

Experts

1.	Matthay, Michael A: 152 articles (12/2021 - 01/2000)
2.	Ware, Lorraine B: 73 articles (01/2022 - 03/2002)
3.	Traber, Daniel L: 56 articles (12/2013 - 09/2002)
4.	Garcia, Joe G N: 54 articles (01/2022 - 05/2003)
5.	Enkhbaatar, Perenlei: 49 articles (12/2020 - 03/2003)
6.	Traber, Lillian D: 46 articles (12/2013 - 09/2002)
7.	Pelosi, Paolo: 41 articles (11/2019 - 11/2003)
8.	Thompson, B Taylor: 40 articles (10/2022 - 01/2000)
9.	Zhang, Wei: 39 articles (08/2022 - 10/2004)
10.	Abraham, Edward: 36 articles (04/2016 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Lung Injury:

1.	LipopolysaccharidesIBA 12/01/2004 - "Mortality associated with acute lung injury (ALI) induced by lipopolysaccharide (LPS) remains high in humans, warranting improved treatment and prevention strategies. " 07/01/2023 - "The study intended to use NP evaluate the protective effects of the fifth eluting fraction of the supernatant of the DYY decoction (DYY-5) for mice induced with acute lung injury (ALI) using lipopolysaccharide (LPS) and to explore DYY-5's mechanisms. " 12/01/2021 - "This study aims to explore the potential protective effects and mechanisms of GLN on acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice. " 11/01/2021 - "The aim of present study is to explore protective effects of EPS on lipopolysaccharide (LPS)-induced inflammatory responses in acute lung injury (ALI). " 10/01/2020 - "To study the effect of Lonicera fulvotometosa(LFH) on expression of genes related to inflammatory pathways in the lung tissue of rats with acute lung injury(ALI) induced by lipopolysaccharide(LPS), explore the lung-protective effects and inflammatory mechanisms of L. "
2.	EndotoxinsIBA 08/01/2001 - "These results suggest that nonspecific blood purification with high-volume CWH improves arterial oxygenation and lung function in endotoxin-induced acute lung injury in pigs, independent of improved hemodynamics, fluid removal, or body temperature." 08/01/2001 - "Thus, the present findings suggest that prophylactic treatment with SOD may be, at least in part, effective for alleviating acute lung injury caused by endotoxins." 12/01/2005 - "These results indicate that endogenous UTI is protective against acute lung injury induced by bacterial endotoxin, at least partly, via the antioxidative properties." 01/01/2014 - "15-deoxy-Δ¹²,¹⁴-prostaglandin J₂ ameliorates endotoxin-induced acute lung injury in rats." 01/01/2021 - "The aim of this study was to evaluate the protective effect of 5-HMF on endotoxin-induced acute lung injury (ALI) and the underlying mechanisms. "
3.	Surface-Active Agents (Surfactants)IBA 11/01/2001 - "We hypothesize that the surfactants most resistant to inactivation in vitro will be the ones that are most effective in treatment of animal models of acute lung injury. " 08/01/2015 - "Surfactant has been shown to be dysfunctional in ARDS, and exogenous surfactant has proven effective in many forms of neonatal and pediatric acute lung injury (ALI). " 09/01/2000 - "Similar injury occurs in animal models of acute lung injury and, in that setting, treatment with exogenous surfactant causes marked improvement in gas exchange. " 04/01/2021 - "• Surfactant acutely improved oxygenation and significantly decreased mortality in children and adolescents with acute lung injury. " 07/01/1998 - "We conclude that dilute surfactants administered by lung lavage are effective in reversing pulmonary dysfunction after acute lung injury. "
4.	Proteins (Proteins, Gene)FDA Link 04/01/2004 - "Alveolar degradation may become important in long-term protein clearance, clearance of insoluble proteins, or under pathological conditions such as immune reactions or acute lung injury. " 03/01/2016 - "Apoptotic human umbilical cord mesenchymal stem cells were more effective in reducing lung neutrophil infiltration and total protein leakage in rat models of acute lung injury (ALI). " 11/01/2017 - "Together, we discovered that the TGF-β-GSK3β-megalin axis is centrally involved in disturbances of alveolar protein clearance in acute lung injury and provide preclinical evidence for therapeutic efficacy of GSK3β inhibition." 01/01/2021 - "Protective effects of recombinant 53-kDa protein of Trichinella spiralis on acute lung injury in mice via alleviating lung pyroptosis by promoting M2 macrophage polarization." 01/01/2022 - "Dedicator of cytokinesis protein 2 knockdown ameliorates LPS-induced acute lung injury by modulating Rac1/2 activity."
5.	CytokinesIBA 02/01/2023 - "The blockade of the overexpression of pro-inflammatory cytokines by anti-inflammatory natural products has been proven therapeutically beneficial in the treatment of acute lung injury (ALI). " 04/01/1996 - "By allowing the monitoring of phenotypic and functional parameters, cultures of pulmonary MVEC isolated from ARDS patients may thus represent a useful system to analyze further the mechanisms of acute lung injury and to evaluate the efficacy of drugs, including inhibitors of cytokines and of adhesion molecules." 05/01/2022 - "(Common Ivy Leaf) standardized extract ameliorates LPS-induced acute lung injury in the mouse model through the inhibition of proinflammatory cytokines and oxidative stress." 06/01/2017 - "The aim of this study was to evaluate whether 6-hydroxyrubiadin can reduce the production of pro-inflammatory cytokines and ameliorate acute lung injury (ALI) in a mouse model. " 05/01/2016 - "Animals were pretreated with DEX (5 and 10 mg/kg, i.p.) for seven days and acute lung injury was induced by intranasal (i.n.) administration of LPS on day 7. In the present study, administration of LPS resulted in significant increase in neutrophils and lymphocytes count whereas a substantial reduction in T cell subsets (CD3(+) and CD4(+)) and pro-inflammatory (IL-6 and TNF-α) cytokines occurred, which were reversed by DEX treatment. "
6.	Oleic Acid (Oleate)IBA 12/01/2006 - "[The protective effects of intermedin 1-53 on oleic acid induced acute lung injury in rats]." 04/01/2004 - "Changes in liquid clearance of alveolar epithelium after oleic acid-induced acute lung injury in rats." 01/01/2020 - "In this study, we used registration of four-dimensional computed tomographic (4DCT) images to assess regional lung aeration and deformation in 10 pigs under baseline conditions and following acute lung injury induced with oleic acid. " 10/25/2019 - "The aim of the present study was to investigate the role of ferroptosis in acute lung injury (ALI) mouse model induced by oleic acid (OA). " 01/01/2019 - "The aim of this study was to examine the role of keratinocyte growth factor-2 (KGF-2) in oleic acid-induced acute lung injury (ALI) in rats. "
7.	ParaquatIBA 01/01/2019 - "The protective effects of bone mesenchymal stem cells on paraquat-induced acute lung injury via the muc5b and ERK/MAPK signaling pathways." 01/01/2015 - "We hypothesized that SF and OMT combination treatment might have protective effects on paraquat-induced acute lung injury. " 10/15/2021 - "The present study investigates whether paraquat (PQ) regulates polarization of alveolar macrophages through glycolysis and promotes the occurrence of acute lung injury in rats. " 06/01/2012 - "This study investigated the effect of the bark extract of Bathysa cuspidata on paraquat (PQ)-induced extra-pulmonary acute lung injury (ALI) and mortality in rats. " 01/01/2023 - "HIF-1α promotes paraquat induced acute lung injury and implicates a role NF-κB and Rac2 activity."
8.	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/01/2002 - "Inhalation of nitric oxide (NO) results in selective pulmonary vasodilation, which may be beneficial in the treatment of acute lung injury. " 05/01/2014 - "The advantages and disadvantages of inhaled nitric oxide (iNO) are better recognized today and iNO is not recommended for ARDS and acute lung injury (ALI) in children and adults because iNO results in a transient improvement in oxygenation but does not reduce mortality, and may be harmful. " 02/01/2007 - "Higher urine nitric oxide is associated with improved outcomes in patients with acute lung injury." 10/01/2016 - "This large observational study demonstrated that inhaled nitric oxide administration in children with acute lung injury was not associated with improved mortality. " 04/07/2004 - "Inhaled nitric oxide has been shown to improve oxygenation in acute lung injury. "
9.	Interleukin-6 (Interleukin 6)IBA 01/01/2017 - "In LPS-challenged mice, aa 11-58 reduced the severity of acute lung injury, with significantly less neutrophil infiltration in the lungs and attenuated pulmonary expression of IL-1β, IL-6, and TNF-α. " 02/27/2023 - "Our findings show that ICD ameliorates IL-6 expression and attenuates phosphorylation of p65 and JNK in BMDMs, and can protect mice from acute lung injury." 01/01/2022 - "Systemic interleukin-6 inhibition ameliorates acute neuropsychiatric phenotypes in a murine model of acute lung injury." 02/27/2023 - "The aim of our study was to determine the potential effects and mechanisms of ICD on pro-inflammatory interleukin-6 (IL-6) expression in bone marrow-derived macrophages (BMDMs) and acute lung injury mouse model. " 02/27/2023 - "The tissue samples of lung, spleen and blood were taken to assess the pathological symptoms of acute lung injury and the expression levels of IL-6. "
10.	InflammasomesIBA 01/01/2021 - "In conclusion, our findings elucidate the anti-inflammatory and protective efficacy of 5-HMF in LPS-induced acute lung injury, and also demonstrate the key mechanism of its action against NLRP3 inflammasome-related inflammatory disorders via the inhibition of ER stress." 07/21/2015 - "An LPS-induced acute lung injury (ALI) mouse model was used to study the in vivo effect of IT on inflammasome activation. " 10/05/2023 - "Total tanshinones protect against acute lung injury through the PLCγ2/NLRP3 inflammasome signaling pathway." 07/01/2023 - "Excessive activation of the NLRP3 inflammasome is involved in the pathological progression of acute lung injury (ALI). " 02/01/2023 - "In this paper, we explored the mechanism of EuHD1 on NLRP3 inflammasome and its effects on acute lung injury and acute liver injury in mice. "

Therapies and Procedures

1.	Therapeutics 11/01/1997 - "Clinical studies are needed to assess whether NO therapy might be beneficial in treatment of severe acute lung injury in older children and adults." 09/01/2012 - "CRRT results in improved oxygenation in post-HSCT children with acute lung injury and this improvement is sustained for at least 48 hours after initiation of this therapy. " 08/01/2010 - "BMDMC therapy was effective at modulating the inflammatory and fibrogenic processes in both acute lung injury models; however, survival and lung mechanics and histology improved more in ALIexp. " 01/01/2022 - "Lung and intestine combination therapy(LICT) is effective in the treatment of acute lung injury(ALI). " 10/23/2019 - "These results are helpful for illuminating the role and mechanism of ADSC paracrine effects and developing effective therapies in acute lung injury."
2.	Liquid Ventilation 03/01/2006 - "Partial liquid ventilation may be beneficial in young patients with acute lung injury or ARDS, although further study is needed to confirm this." 10/01/2003 - "We sought to know whether there is a further improvement in gas exchange when partial liquid ventilation (PLV) is added to high-frequency oscillatory ventilation (HFOV) in a piglet model of saline lavage-induced acute lung injury. " 01/01/2002 - "Partial liquid ventilation (PLV) with various types of perfluorochemicals (PFC) has been shown to be beneficial in treating acute lung injury. " 12/01/2001 - ""Ideal PEEP" is superior to high dose partial liquid ventilation with low PEEP in experimental acute lung injury." 02/01/1997 - "To determine whether there is an improvement in oxygenation when partial liquid ventilation and high-frequency oscillatory ventilation are combined in the treatment of acute lung injury, compared with high-frequency oscillatory ventilation alone. "
3.	Artificial Respiration (Mechanical Ventilation) 04/01/2006 - "In patients with acute lung injury, a diet enriched with EPA + GLA may be beneficial for gas exchange, respiratory dynamics, and requirements for mechanical ventilation." 01/01/2009 - "Better understanding of the pathophysiology of acute lung injury and progress in supportive care and mechanical ventilation have led to slightly improved clinical outcomes. " 01/01/2011 - "Lung protective ventilation (LPV) has been shown to improve survival and the duration of mechanical ventilation in acute lung injury (ALI) patients. " 07/26/2023 - "Keyword analysis revealed that the main research focus included stress disorders, quality of life, mechanical ventilation, acute lung injury, risk factors, and descriptive studies during hospitalization. " 05/01/2015 - "In this study, we employed lung protective ventilation strategies in patients without acute lung injury (ALI) to determine whether mechanical ventilation with lower tidal volume would provide more clinical benefits to patients without ALI. "
4.	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 01/01/1989 - "Pulmonary clearance of radiotracers after positive end-expiratory pressure or acute lung injury." 01/01/2016 - "Purpose of this study is to assess the distribution of VREG vs PTP,REG along the gravitational axis in healthy (HL) and experimental acute lung injury conditions (eALI) at various positive end-expiratory pressures (PEEPs) and inflation volumes. " 01/01/2008 - "Recent papers discussed include two large, multicentre, high-positive end-expiratory pressure trials in acute lung injury and reflects upon the usefulness of such trial designs. " 06/01/2007 - "Two methods of setting positive end-expiratory pressure in acute lung injury: an experimental computed tomography volumetric study." 03/01/2007 - "The goal of this study was to determine whether changes in lung mechanical heterogeneity with increasing positive end-expiratory pressure in an animal model of acute lung injury could be detected from the frequency responses of resistance and elastance. "
5.	Mechanical Ventilators (Ventilator) 09/01/2006 - "Several previous investigations have shown improved oxygenation when ventilator-treated patients with acute lung injury are turned prone. " 06/01/2023 - "Previous trials conducted in National Heart, Lung, and Blood Institute ARDS Clinical Trials (ARDSNet) and Prevention and Early Treatment of Acute Lung Injury (PETAL) Networks informed ventilator management, ventilation liberation and fluid management protocols. " 03/15/2016 - "In the present study, we demonstrate that levels of CFH in the air space correlate with measures of alveolar-capillary barrier dysfunction in humans with ARDS (r = 0.89, P < 0.001) and in mice with ventilator-induced acute lung injury (r = 0.89, P < 0.001). " 02/01/2014 - "The use of β2 agonist as an intervention for acute lung injury (ALI) and ARDS patients is controversial, so we performed a systematic review and meta-analysis of the published randomized controlled trials of using β2 agonists to improve outcomes (mortality and ventilator free days) among patients with ALI/ARDS. " 11/23/2012 - "Objective: To determine if dietary supplementation of these substances to patients with acute lung injury would increase ventilator-free days to study day 28. "