|1.||Zeeuwen, Patrick L J M: 4 articles (11/2012 - 07/2003)|
|2.||Schalkwijk, Joost: 4 articles (11/2012 - 07/2003)|
|3.||van Vlijmen-Willems, Ivonne M J J: 4 articles (11/2012 - 07/2003)|
|4.||Keppler, Daniel: 4 articles (09/2008 - 03/2004)|
|5.||Wu, Jean: 3 articles (01/2006 - 09/2003)|
|6.||Zacharias, Wolfgang: 3 articles (01/2006 - 09/2003)|
|7.||Vigneswaran, Nadarajah: 3 articles (01/2006 - 09/2003)|
|8.||Hitomi, Kiyotaka: 2 articles (10/2010 - 05/2004)|
|9.||Hara-Nishimura, Ikuko: 2 articles (10/2010 - 05/2004)|
|10.||Johansen, Harald T: 2 articles (01/2010 - 05/2004)|
|1.||Breast Neoplasms (Breast Cancer)
01/01/2010 - "This study was aimed at understanding the clinicopathological significance of cystatin M loss, and investigating possible factors responsible for cystatin M loss in breast cancer. "
03/18/2004 - "This study provides the first evidence that cystatin M may play important roles in safeguarding against human breast cancer."
01/01/2010 - "Aberrant promoter methylation is a well-known mechanism that participates in cystatin M silencing in breast cancer. "
12/15/2009 - "The methylation status of cystatin M (CST6) gene in breast tumors was investigated and its prognostic significance as a novel breast cancer biomarker was evaluated. "
12/15/2009 - "Methylation of cystatin M promoter is associated with unfavorable prognosis in operable breast cancer."
|2.||Neoplasm Metastasis (Metastasis)
01/01/2005 - "Our findings are at variance with a previous report proposing a metastasis suppressive function for cystatin M. "
10/01/2004 - "The incidence of metastasis, however, appeared to be unaltered between the cystatin M group and the control group. "
01/01/2005 - "Therefore, additional studies in a larger series with adequate follow-up are necessary to elucidate the biologic significance of cystatin M expression in breast cancer metastasis."
10/01/2007 - "25/45 (56%) primary tumors and 17/20 (85%) lymph node metastases expressed significantly lower levels of cystatin M compared to normal breast tissue. "
10/01/2004 - "Experimental metastasis assays suggest that cystatin M suppressed tumor cell proliferation at the secondary site. "
01/01/2010 - "Moreover, a statistically significant inverse association was found between cystatin M methylation status and expression of the cystatin M protein in tumor tissues (p=0.027). "
01/01/2010 - "55% (33 of 60) of primary tumors analyzed displayed cystatin M promoter hypermethylation, indicating that this aberrant characteristic is common in gastric malignancies. "
12/15/2008 - "Here, we report that the Cystatin M (CST6) tumor suppressor gene is concurrently down-regulated with other loci in breast epithelial cells cocultured with cancer-associated fibroblasts (CAF). "
09/01/2008 - "Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer."
10/01/2007 - "In 2/3 (67%) patients, primary tumors were positive for cystatin M and negative for CST6 promoter methylation, and matched metastatic lesions lacked cystatin M expression and CST6 was hypermethylated. "
09/01/2008 - "In our previous studies we identified cystatin E/M (CST6) as a frequent target of epigenetic silencing in glioma. "
09/01/2008 - "Finally, ectopic expression of cystatin E/M in glioma lines reduced cell motility and invasion. "
09/01/2008 - "Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas."
09/01/2008 - "Cystatin E/M is a potent inhibitor of cathepsin B, which is frequently overexpressed in glioma. "
01/01/2010 - "These results suggest that cystatin M promoter hypermethylation is one of the molecular mechanisms that accounts for reduced cystatin M gene expression in gastric carcinomas."
01/01/2010 - "Lost expression of cystatin M was observed in 42 of 60 (70%) gastric carcinomas. "
01/01/2010 - "Immunohistochemistry was used to investigate the expression of cystatin M in 60 gastric carcinomas. "
01/01/2010 - "Cystatin M expression is reduced in gastric carcinoma and is associated with promoter hypermethylation."
05/10/2007 - "Our results show that cystatin M is frequently epigenetically inactivated during breast carcinogenesis and cystatin M expression suppresses the growth of breast carcinoma. "
|1.||Cysteine Proteases (Cysteine Protease)
|2.||Messenger RNA (mRNA)
|5.||Proteins (Proteins, Gene)
|6.||Protease Inhibitors (Protease Inhibitor)
|9.||Small Interfering RNA (siRNA)
|10.||Progesterone Receptors (Progesterone Receptor)