|1.||Lehesjoki, Anna-Elina: 12 articles (04/2015 - 01/2002)|
|2.||Joensuu, Tarja: 6 articles (04/2015 - 02/2007)|
|3.||Kopra, Outi: 6 articles (03/2015 - 05/2009)|
|4.||Kopitar-Jerala, Nataša: 5 articles (01/2015 - 01/2012)|
|5.||Tegelberg, Saara: 5 articles (01/2014 - 02/2007)|
|6.||Turk, Vito: 5 articles (01/2012 - 10/2002)|
|7.||Zerovnik, Eva: 5 articles (11/2010 - 01/2005)|
|8.||Koskenkorva, Päivi: 3 articles (04/2015 - 12/2012)|
|9.||Kälviäinen, Reetta: 3 articles (04/2015 - 12/2012)|
|10.||Vanninen, Ritva: 3 articles (04/2015 - 12/2012)|
|1.||Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy)
05/06/2009 - "Collectively, our findings define a pathophysiological mechanism in EPM1, whereby Cystatin B deficiency couples oxidative stress to neuronal death and degeneration, and may thus provide the basis for novel treatment approaches for the progressive myoclonus epilepsies."
04/14/2015 - "This Finnish nationwide study aimed to refine the clinical phenotype variability and to identify factors that could explain the extensive variability in the clinical severity of the symptoms observed among patients with Unverricht-Lundborg disease (progressive myoclonus epilepsy type 1 [EPM1]) homozygous for the dodecamer expansion mutation in the cystatin B (CSTB) gene. "
10/01/2013 - "To study white matter (WM) changes in patients with Unverricht-Lundborg progressive myoclonus epilepsy (EPM1) caused by mutations in the cystatin B gene and in the cystatin B-deficient (Cstb-/-) mouse model and to validate imaging findings with histopathologic analysis of mice. "
10/01/2013 - "White matter degeneration with Unverricht-Lundborg progressive myoclonus epilepsy: a translational diffusion-tensor imaging study in patients and cystatin B-deficient mice."
12/01/2013 - "Cystatin B (CSTB) is an anti-protease frequently mutated in progressive myoclonus epilepsy (EPM1), a devastating degenerative disease. "
04/01/2014 - "Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-β signaling pathway."
02/01/2009 - "Cystatin B urine levels are positively correlated with tumor grade, stage, and shorter time to disease recurrence and progression. "
02/01/2009 - "Elevated urinary cystatin B levels correlated with increasing tumor grade (P = 0.062) and stage (P = 0.0047). "
04/17/1998 - "The expression of cystatin B in tumor tissue was found to be markedly decreased compared with that of the corresponding normal tissue. "
07/15/1994 - "As these properties are similar to Stefin B from human and bovine origin, as well as to Stefin B from human histiosarcoma, we believe that tumor Stefin B does not differ from normal Stefin B."
04/01/2015 - "Cystatin B as a potential diagnostic biomarker in ovarian clear cell carcinoma."
03/01/2003 - "The decrease in median cytoplasmic staining of cystatin B in carcinomas compared to other lesions was significant, but there was a significant increase in expression with dedifferentiation of carcinoma. "
04/17/1998 - "The decreased expression of cystatin B protein in carcinoma tissue was confirmed by immunohistochemical staining. "
04/17/1998 - "There is little information on the clinical significance of cystatin B expression in human esophageal carcinoma. "
07/15/1994 - "Stefin B, the major low molecular weight inhibitor in ovarian carcinoma."
|4.||Neoplasm Metastasis (Metastasis)
04/17/1998 - "Our study suggests that reduced expression of cystatin B in esophageal-carcinoma tissue is associated with lymph-node metastasis and may therefore prove to be a useful marker for predicting the biologic aggressiveness of human esophageal carcinoma."
04/17/1998 - "Identification of cystatin B in human esophageal carcinoma, using differential displays in which the gene expression is related to lymph-node metastasis."
04/01/2013 - "Downregulation of 14-3-3ζ/δ, cystatin-B, Ran and thioredoxin could be a result of their secretion, which then stimulates metastasis via activity in the sera and ascitic fluids. "
09/01/2012 - "We confirmed by Western blot, ELISA, and real-time PCR that the expression of metastasis-related genes CXCL1, CXCL2, CXCL5, MMP-2, and MMP-9 were significantly decreased while that of E-Cadherin and cystatin B were dramatically increased in A549- and PC9-ITGB8 silencing cells. "
03/01/2013 - "Metastasis-related genes E-cadherin, MMP-2/9 and cystatin B, as well as the signaling molecules p-Akt, NF-κB, and AP-1 activation, were also modulated. "
11/14/2014 - "In this study we demonstrated that stefin B-deficient (StB KO) mice were significantly more sensitive to the lethal LPS-induced sepsis and secreted higher amounts of pro-inflammatory cytokines IL-1β and IL-18 in the serum. "
01/01/2015 - "In our recent work, we demonstrated that stefin B-deficient mice were significantly more sensitive to the lethal lipopolysaccharide (LPS)-induced sepsis, due to increased caspase-11 expression and secreted higher amounts of pro-inflammatory cytokines IL-1β and IL-18. "
|3.||Cysteine Proteases (Cysteine Protease)
|7.||Proteins (Proteins, Gene)
|9.||Interleukin-18 (Interleukin 18)