Immunoglobulin Idiotypes

Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains.

Also Known As:

Idiotype, Immunoglobulin; Idiotype, Ig; Idiotypes, Ig; Ig Idiotype; Immunoglobulin Idiotype; Idiotypes, Immunoglobulin; Ig Idiotypes

Pharmalogical Action Categories:

Immunologic Factors

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Fragments: 976
        Immunoglobulin Idiotypes: 67
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Immunoglobulin Fragments: 976
        Immunoglobulin Idiotypes: 67
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Immunoglobulin Fragments: 976
        Immunoglobulin Idiotypes: 67
- Peptides: 82426
  - Peptide Fragments: 373
    - Immunoglobulin Fragments: 976
      - Immunoglobulin Idiotypes: 67
Biological Factors: 2472
- Antigens: 143924
  - Epitopes: 19548
    - Immunoglobulin Idiotypes: 67
Chemical Phenomena
- Biochemical Phenomena
  - Molecular Structure
    - Amino Acid Sequence
      - Immunoglobulin Variable Region: 208
        Immunoglobulin Idiotypes: 67
Immune System Phenomena
- Immunogenetic Phenomena
  - Immunoglobulin Idiotypes: 67

Immunogenetic Phenomena

Context: Research Results