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Delayed Emergence from Anesthesia

Abnormally slow pace of regaining CONSCIOUSNESS after general anesthesia (ANESTHESIA, GENERAL) usually given during surgical procedures. This condition is characterized by persistent somnolence.
Also Known As:
Delayed Awakening, Post-Procedural; Delayed Recovery from Anesthesia; Delayed Regaining of Consciousness; Delayed Return of Consciousness; Postoperative Residual Curarisation; Postoperative Residual Curarization; Postoperative Residual Weakness; Residual Block; Residual Neuromuscular Block; Residual Neuromuscular Blockade; Residual Paralysis, Post-Anesthesia; Awakening, Post-Anesthesia Delayed; Awakenings, Post-Anesthesia Delayed; Block, Residual; Block, Residual Neuromuscular; Blockade, Residual Neuromuscular; Blockades, Residual Neuromuscular; Blocks, Residual; Blocks, Residual Neuromuscular; Curarization, Postoperative Residual; Curarizations, Postoperative Residual; Delayed Awakening, Post Anesthesia; Delayed Awakening, Post Procedural; Delayed Awakenings, Post-Anesthesia; Delayed Awakenings, Post-Procedural; Neuromuscular Block, Residual; Neuromuscular Blockade, Residual; Neuromuscular Blockades, Residual; Neuromuscular Blocks, Residual; Paralyses, Post-Anesthesia Residual; Paralysis, Post-Anesthesia Residual; Post-Anesthesia Delayed Awakening; Post-Anesthesia Delayed Awakenings; Post-Anesthesia Residual Paralyses; Post-Anesthesia Residual Paralysis; Post-Procedural Delayed Awakening; Post-Procedural Delayed Awakenings; Postoperative Residual Curarisations; Postoperative Residual Curarizations; Postoperative Residual Weaknesses; Residual Blocks; Residual Curarisation, Postoperative; Residual Curarisations, Postoperative; Residual Curarization, Postoperative; Residual Curarizations, Postoperative; Residual Neuromuscular Blockades; Residual Neuromuscular Blocks; Residual Paralyses, Post-Anesthesia; Residual Paralysis, Post Anesthesia; Residual Weakness, Postoperative; Residual Weaknesses, Postoperative; Weakness, Postoperative Residual; Weaknesses, Postoperative Residual; Delayed Awakening from Anesthesia; Delayed Awakening, Post-Anesthesia
Networked: 363 relevant articles (8 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Chronic Kidney Failure (Chronic Renal Failure)
2. Delayed Emergence from Anesthesia
3. Pain (Aches)
4. Respiratory Insufficiency (Respiratory Failure)
5. Airway Obstruction (Choking)

Experts

1. Eikermann, Matthias: 7 articles (01/2020 - 03/2006)
2. Cammu, G: 6 articles (11/2018 - 02/2002)
3. Ledowski, Thomas: 5 articles (01/2021 - 01/2013)
4. Brull, Sorin J: 5 articles (04/2020 - 07/2010)
5. Murphy, Glenn S: 4 articles (01/2021 - 05/2003)
6. Kopman, Aaron F: 4 articles (01/2019 - 01/2004)
7. Naguib, Mohamed: 4 articles (01/2019 - 03/2007)
8. Carron, Michele: 4 articles (01/2018 - 08/2012)
9. Blobner, Manfred: 4 articles (11/2010 - 03/2006)
10. Avram, Michael J: 3 articles (01/2021 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Delayed Emergence from Anesthesia:
1. SugammadexIBA
2. Neostigmine (Neostigmine Bromide)IBA
3. Vecuronium Bromide (Vecuronium)FDA LinkGeneric
4. Rocuronium (Zemuron)FDA LinkGeneric
5. Anesthetics (Anesthetic Agents)IBA
6. Glycopyrrolate (Glycopyrronium Bromide)FDA LinkGeneric
7. Pyridostigmine Bromide (Pyridostigmine)FDA LinkGeneric
8. Flumazenil (Romazicon)FDA LinkGeneric
9. Propofol (Diprivan)FDA LinkGeneric
10. Neuromuscular Blocking AgentsIBA

Therapies and Procedures

1. Anesthesia
2. General Anesthesia
3. Operative Surgical Procedures
4. Therapeutics
5. Critical Care (Surgical Intensive Care)
11/01/2018 - "Postoperative residual curarisation is still an issue when weaning patients in intensive care following cardiac surgery."
01/01/2018 - "Residual Neuromuscular Blockade in the Critical Care Setting."
06/01/2012 - "Residual neuromuscular blockade in critical care."
03/01/2022 - "Although SFAR recommendations (French Society of Anesthesia & Intensive Care Medicine) were generally well followed, the use of neuromuscular blockade reversal drugs was observed to be not fully integrated into regular practice, despite the fact that more than half of patients were reported to have residual neuromuscular blockade post-surgery and that sugammadex is known to reduce time spent in the OR and PACU compared to other neuromuscular blockade reversal methods."
01/01/2023 - "A modified Delphi consensus analysis (experts, working group, and previous extensive bibliographic revision) 10 recommendations were produced1: neuromuscular blocking agents were recommended for endotracheal intubation and to avoid faringo-laryngeal and tracheal lesions, including critical care patients.2 We recommend not to use neuromuscular blocking agents for routine insertion of supraglotic airway devices, and to use it only in cases of airway obstruction or endotracheal intubation through the device.3 We recommend to use a rapid action neuromuscular blocking agent with an hypnotic in rapid sequence induction of anesthesia.4 We recommend profound neuromuscular block in laparoscopic surgery.5 We recommend quantitative monitoring of neuromuscular blockade during the whole surgical procedure, provided neuromuscular blocking agents have been used.6 We recommend quantitative monitoring through ulnar nerve stimulation and response evaluation of the adductor pollicis brevis, acceleromyography being the clinical standard.7 We recommend a recovery of neuromuscular block of at least TOFr ≥ 0.9 to avoid postoperative residual neuromuscular blockade.8 We recommend drug reversal of neuromuscular block at the end of general anesthetic, before extubation, provided a TOFr ≥ 0.9 has not been reached.9 We recommend to choose anticholinesterases for neuromuscular block reversal only if TOF≥2 and a TOFr ≥ 0.9 has not been attained.10 We recommend to choose sugammadex instead of anticholinesterases for reversal of neuromuscular blockade induced with rocuronium."