Osteochondrosis (Osgood Schlatter Disease)

Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).
Also Known As:
Osgood Schlatter Disease; Koehler's Disease; Koehlers Disease; Osteochondroses; Koehler Disease; Osgood-Schlatter Disease
Networked: 342 relevant articles (14 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Neurologic Manifestations (Neurological Manifestations)
2. Tendinopathy (Tendonitis)
3. Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)
4. Pain (Aches)
5. Intra-Articular Fractures


1. van Weeren, P R: 4 articles (12/2011 - 02/2000)
2. Serteyn, D: 3 articles (11/2011 - 02/2007)
3. Distl, O: 3 articles (11/2009 - 01/2006)
4. Grace, N D: 3 articles (12/2005 - 08/2001)
5. Nixon, Alan J: 3 articles (09/2005 - 11/2002)
6. Semevolos, Stacy A: 3 articles (09/2005 - 11/2002)
7. Serteyn, Didier: 2 articles (01/2015 - 10/2011)
8. Khizhniak, M V: 2 articles (03/2013 - 01/2001)
9. Lepage, O: 2 articles (12/2011 - 05/2008)
10. Donabédian, M: 2 articles (12/2011 - 05/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteochondrosis:
1. CalciumIBA
2. Insulin-Like Growth Factor I (IGF-1)IBA
3. hydroxide ionIBA
11/29/2002 - "Large-breed pups fed on a standard diet supplemented with Ca and P had decreased plasma concentrations of both 25(OH)D(3) and 1,25(OH)(2)D(3), which may indicate an increased clearance of these metabolites; the low plasma concentrations of the di-hydroxylated vitamin D metabolites were considered responsible for the disturbance in cartilage maturation (i.e., osteochondrosis) in these dogs. "
06/01/2003 - "It is suggested that in GD, increased calcitonin levels and/or a relative deficiency in 24,25(OH)2D3 at the growth-plate level may both be responsible for the retarded maturation of chondrocytes, resulting in retained cartilage cones and osteochondrosis, and this may be a pathophysiological factor for the increased susceptibility of large breed dogs to developing skeletal disorders."
01/01/1989 - "The incidence of osteochondrosis at 2 weeks was, respectively, 0/8, 0/8, 0/8, 0/8, 0/8, and 1/8, and at 4 weeks was, respectively, 0/8, 0/8, 0/8, 2/8, 2/8 and 2/8. The NRC (1988) estimate of the requirement for vitamin D may be somewhat low since the concentration of plasma 25(OH)D was lower with 200 or 1,000 IU vitamin D/kg diet than at the start."
11/01/1999 - "PTH, 1,25(OH)2D, cortisol, copper, zinc and calcium also showed significant differences between osteochondrosis-positive and osteochondrosis-negative foals."
11/01/1999 - "The present study focused on a possible relationship between insulin-like growth factor I (IGF-I), insulin-like growth factor II (IGF-II), parathyroid hormone (PTH), 1,25-dihydroxy-vitamin D (1,25(OH)2D), cortisol, copper, zinc, calcium, ionised calcium, magnesium and phosphorus and 5 different postmortem and radiographical osteochondrosis scores of hock and stifle joints in foals age 0-11 months. "
4. Propranolol (Inderal)FDA LinkGeneric
5. CollagenIBA
6. PapainIBA
7. Vitamin DFDA LinkGeneric
8. Proteoglycans (Proteoglycan)IBA
9. Carbon MonoxideIBA
10. Nifedipine (Adalat)FDA LinkGeneric

Therapies and Procedures

1. Osteotomy
2. Lasers (Laser)
3. Injections
4. Musculoskeletal Manipulations (Manipulative Therapy)
5. Surgical Casts (Plaster Cast)