Osteochondrosis (Osgood Schlatter Disease)

Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).

Also Known As:

Osgood Schlatter Disease; Koehler's Disease; Navicular Osteochondrosis; Koehlers Disease; Navicular Osteochondroses; Osteochondroses; Osteochondroses, Navicular; Osteochondrosis, Navicular; Koehler Disease; Osgood-Schlatter Disease

Networked: 462 relevant articles (22 outcomes, 38 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Bone Diseases: 5863
  - Osteochondrosis: 462

Related Diseases

1.	Neurologic Manifestations (Neurological Manifestations)
2.	Pain (Aches)
3.	Tendinopathy (Tendonitis)
4.	Myocardial Ischemia (Ischemic Heart Diseases)
5.	Osteochondrodysplasias (Spondyloepiphyseal Dysplasia)

Experts

1.	Semevolos, Stacy A: 7 articles (01/2022 - 11/2002)
2.	van Weeren, P R: 5 articles (11/2013 - 02/2000)
3.	Distl, O: 5 articles (11/2009 - 01/2006)
4.	Kovalenko, A L: 3 articles (01/2021 - 01/2017)
5.	Parfenov, S A: 3 articles (01/2021 - 01/2017)
6.	Vasilevskaya, M A: 3 articles (01/2021 - 01/2017)
7.	Chiaradia, Elisabetta: 3 articles (01/2020 - 07/2012)
8.	Laverty, S: 3 articles (05/2018 - 05/2000)
9.	Carlson, C S: 3 articles (09/2016 - 12/2000)
10.	McIlwraith, C Wayne: 3 articles (07/2013 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Osteochondrosis:

1.	Phosphorus (Red Phosphorus)IBA 07/27/2016 - "Osteochondrosis has a multifactorial aetiology and this study focused on the role of minerals, particularly phosphorus, in the development of the disease. " 07/27/2016 - "A significant improvement in the clinical signs in experimental animals and a reduction of osteochondrosis occurred on farms where animals received bioavailable trace minerals and phosphorus as part of a balanced lick. " 12/02/2000 - "The dogs fed the high calcium and phosphorus diet became slightly hypophosphataemic, their growth was retarded, and they had disturbances in skeletal development resembling osteochondrosis, which had only partly resolved after 10 weeks on the normal calcium and phosphorus diet." 09/01/1983 - "[Effect of calcium and phosphorus supply on osteochondrosis in fattening swine]." 01/01/1978 - "Effects of vitamin D and A, calcium, phosphorus, and protein on frequency and severity of osteochondrosis in pigs."
2.	CalciumIBA 01/01/1991 - "Osteochondrosis in fetuses of ewes overfed calcium." 12/02/2000 - "The dogs fed the high calcium and phosphorus diet became slightly hypophosphataemic, their growth was retarded, and they had disturbances in skeletal development resembling osteochondrosis, which had only partly resolved after 10 weeks on the normal calcium and phosphorus diet." 09/01/1983 - "[Effect of calcium and phosphorus supply on osteochondrosis in fattening swine]." 07/14/1990 - "Growth cartilages with dyschondroplastic foci (osteochondrosis) or areas of chondrolysis were selected from the ribs and bones of the appendicular skeleton of 132 commercial pigs euthanased between one and 169 days old or at a liveweight of 100 kg. Histochemical staining techniques that identified proteoglycans, collagen and deposits of calcium enhanced the visualisation of the lesions, were valuable for recognising the distribution of lesions, and helped to elucidate the development of the lesions. " 11/01/1995 - "Considerable changes of collagen, glycosaminoglycans and calcium were observed both in vertebral tissues, bone, and in the heart, vessels, liver during development of "experimental osteochondrosis". "
3.	RadonIBA 01/01/2022 - "The work aimed at investigating the therapeutic efficacy of radon baths in patients suffering from osteochondrosis. " 01/01/2022 - "A significant number of authors report a positive effect of radon baths on the condition of patients with osteochondrosis. " 01/01/2022 - "The use of radon baths in the rehabilitation of patients with osteochondrosis." 07/01/1992 - "[The effect of radon baths on the rheological properties of the erythrocytes in osteochondrosis patients]." 11/01/1977 - "[Clinico-electrophysiological basis of the use of radon baths of different concentrations in neurological syndromes of lumbar osteochondrosis]."
4.	Insulin-Like Growth Factor I (IGF-1)IBA 07/01/2001 - "Cartilage obtained from osteochondrosis lesions had significantly greater expression of IGF-I, compared with normal cartilage. " 10/01/2009 - "This result may still reflect an earlier imbalance in IGF-I levels from horses with developmental osteochondral lesions considering the aetiopathological link which has been made between IGF-I and the occurrence of osteochondrosis. " 11/01/1999 - "Osteochondrosis-positive foals showed a significantly lower IGF-I activity than osteochondrosis-negative foals. " 10/01/1992 - "Increased concentrations of IGF-I, T3 and T4 could be causally related to osteochondrosis, which frequently occurs in intensively fed dogs." 05/01/1995 - "Porcine osteochondrosis: deficiencies in transforming growth factor-beta and insulin-like growth factor-I."
5.	hydroxide ionIBA 09/29/2017 - "FokI, BsmI, ApaI, and TaqI VDR-polymorphisms were detected through PCR-restriction fragment length polymorphism (RFLP), and circulating 25(OH)D, CTx-I and CTx-II were measured by immunoassays in 79 patients (of which 26 had osteochondrosis) and 79 age-, sex- and body mass index (BMI)-matched healthy controls. " 06/01/2003 - "It is suggested that in GD, increased calcitonin levels and/or a relative deficiency in 24,25(OH)2D3 at the growth-plate level may both be responsible for the retarded maturation of chondrocytes, resulting in retained cartilage cones and osteochondrosis, and this may be a pathophysiological factor for the increased susceptibility of large breed dogs to developing skeletal disorders." 01/01/1989 - "The incidence of osteochondrosis at 2 weeks was, respectively, 0/8, 0/8, 0/8, 0/8, 0/8, and 1/8, and at 4 weeks was, respectively, 0/8, 0/8, 0/8, 2/8, 2/8 and 2/8. The NRC (1988) estimate of the requirement for vitamin D may be somewhat low since the concentration of plasma 25(OH)D was lower with 200 or 1,000 IU vitamin D/kg diet than at the start." 11/29/2002 - "Large-breed pups fed on a standard diet supplemented with Ca and P had decreased plasma concentrations of both 25(OH)D(3) and 1,25(OH)(2)D(3), which may indicate an increased clearance of these metabolites; the low plasma concentrations of the di-hydroxylated vitamin D metabolites were considered responsible for the disturbance in cartilage maturation (i.e., osteochondrosis) in these dogs. " 09/29/2017 - "We evaluated the association between the circulating 25-hydroxyvitamin D (25(OH)D) type I and II collagen degradation products (CTx-I, and CTx-II), and four vitamin D receptor gene (VDR) polymorphisms, in Italian males affected by low back pain (LBP) due to herniation/discopathy and/or vertebral osteochondrosis. "
6.	Trace Elements (Biometals)IBA 03/01/2013 - "The objectives of this study were to determine if prolific sows displayed evidence of trace mineral depletion with age and to determine the prevalence of osteochondrosis (OC) lesions. " 09/01/2016 - "Maternal and progeny diets supplemented with 2 sources of trace mineral (TM) were evaluated for effects on the size and severity of osteochondrosis (OC) lesions in progeny produced by 64 Landrace × Large White sows. " 09/01/2016 - "Osteochondrosis prevalence and severity at 12 and 24 weeks of age in commercial pigs with and without organic-complexed trace mineral supplementation." 01/01/1972 - "[Dynamics of the trace element composition of the human intervertebral disk in osteochondrosis]." 07/27/2016 - "A significant improvement in the clinical signs in experimental animals and a reduction of osteochondrosis occurred on farms where animals received bioavailable trace minerals and phosphorus as part of a balanced lick. "
7.	Propranolol (Inderal)FDA LinkGeneric 03/01/1989 - "The study performed by the authors into the effect of low-frequency magnetic field on coronary heart disease, cervical and thoracic osteochondrosis arising in senile and presenile patients showed the treatment to promote improvement of the heart autonomic regulation and attenuation of ischemic and vertebrogenic pain, to augment response to antiarrhythmic treatment in coronary patients with extrasystoles, to compensate for negatively inotropic effect of propranolol hydrochloride, to increase exercise tolerance." 10/01/1991 - "The efficacy of drug (inderal, corinfar) treatment in combination with manual therapy (the course was 4-7 sessions) was examined in hypertensives with cervical osteochondrosis. "
8.	CollagenIBA 12/01/2014 - "Treatment of focal cartilage defects (traumatic or osteochondrosis dissecans) of the talus using a collagen matrix. " 01/01/1994 - "Characterisation of articular and growth plate cartilage collagens in porcine osteochondrosis." 01/01/1986 - "We conclude that a disturbance of collagen or ground substance biosynthesis is of importance in the pathogenesis of juvenile osteochondrosis." 01/01/1986 - "In osteochondrosis juvenilis Scheuermann, foci of various sizes in the cartilaginous end plates of the vertebral bodies display a loosening or complete interruption of the collagen fibers. " 01/01/1974 - "[The lymphocyte blast-transformation reaction under the influence of collagen in osteochondrosis patients with a radicular syndrome]."
9.	PapainIBA 09/01/1980 - "The use of Soviet papain makes possible effective treatment of patients suffering from lumbar osteochondrosis." 08/01/1984 - "[Clinico-electromyographic parallels in the evaluation of the results of treating lumbar osteochondrosis by the papain nucleolysis technic]." 10/01/1980 - "[Biochemical mechanisms of the action of papain on the connective tissue of the intervertebral disks in osteochondrosis]." 10/01/1977 - "[Effectiveness of treatment of lumbar osteochondrosis with intradiscal infusion of papain]." 08/01/1973 - "[Treatment of lumbar osteochondrosis by intradiscal infusion of papain]."
10.	Proteoglycans (Proteoglycan)IBA 01/01/2021 - ": SF proteoglycan-4 concentration increased in acute-joint-injury (1185 ± 276 versus normal 205 ± 106 µg/mL, µ± SEM, p < 0.01), with increased percentage of lower molecular-weight hyaluronan in acute-joint-injury and osteochondrosis. " 10/01/2016 - "Subregions in neonatal foal femoral epiphyses (n = 10 osteochondrosis predisposed; n = 6 control) were assessed for proteoglycan and collagen structure/content employing 3T quantitative MRI (3T qMRI: T1ρ and T2 maps). " 11/01/2005 - "Comparison of proteoglycan and collagen in articular cartilage of horses with naturally developing osteochondrosis and healing osteochondral fragments of experimentally induced fractures." 01/01/2021 - "The objectives were to characterize composition (proteoglycan-4, hyaluronan), and function of SF and serum from normal horses compared to clinical groups: osteoarthritis, acute-joint-injury, and osteochondrosis.Materials" 07/14/1990 - "Growth cartilages with dyschondroplastic foci (osteochondrosis) or areas of chondrolysis were selected from the ribs and bones of the appendicular skeleton of 132 commercial pigs euthanased between one and 169 days old or at a liveweight of 100 kg. Histochemical staining techniques that identified proteoglycans, collagen and deposits of calcium enhanced the visualisation of the lesions, were valuable for recognising the distribution of lesions, and helped to elucidate the development of the lesions. "

Therapies and Procedures

1.	Osteotomy 01/01/2006 - "We report a case of genu recurvatum secondary to Osgood-Schlatter disease treated successfully with proximal tibial osteotomy and distraction with a Taylor spatial frame." 08/01/2017 - "To evaluate the functional and clinical outcome of a new closing-wedge osteotomy for the prominent tibial tubercle after Osgood-Schlatter disease. " 08/01/2017 - "Reduction Osteotomy of the Prominent Tibial Tubercle After Osgood-Schlatter Disease." 07/01/1996 - "[Postoperative evaluation of osteochondrosis dissecans of the talus with special reference to medial malleolar osteotomy]." 12/01/1969 - "[Osteotomy for directional and biological purposes in osteochondrosis in childhood]."
2.	Conservative Treatment 12/15/1997 - "Conservative management does not result in a favorable clinical prognosis for long-term, lameness-free survival, and more studies need to be completed to evaluate the efficacy of surgical treatment of osteochondrosis in cattle." 01/01/2020 - "The aim of the study was to assess the efficacy and safety of the conservative treatment of Osgood-Schlatter disease in young professional soccer players. " 01/01/1989 - "The studies conducted provided evidence for a beneficial effect of long-term (1.5 -- 6 mos) combined conservative therapy for severe compression syndrome in lumbar osteochondrosis. " 05/01/2021 - "A systematic review on conservative treatment options for OSGOOD-Schlatter disease." 01/01/2021 - "The purpose of this case series is to report the outcomes of ossicle excision and tubercleplasty for unresolved Osgood-Schlatter disease that has failed conservative treatment in six adolescent athletes. "
3.	Therapeutics 11/01/2011 - "Our results suggest superior symptom-reduction efficacy of injection therapy over usual care in the treatment of Osgood-Schlatter disease in adolescents. " 09/01/1985 - "[Clinico-electroneuromyographic evaluation of the efficacy of decimeter-wave therapy in patients with neurologic syndromes of lumbar osteochondrosis]." 01/01/2022 - "The patients included in this study underwent surgical stabilization of the lumbar and/or thoracic spine with removal of 1 or more affected intervertebral discs, as therapy for VO (n = 16) or for erosive osteochondrosis (EO, control group, n = 20). " 03/01/2010 - "Analysis of locomotor disturbances and their dynamics under effect of remedial gymnastics prescribed on an individual basis showed that the main factor limiting success of osteochondrosis therapy is muscular disbalance in the pelvic girdle. " 05/01/2009 - "The patients of the control group received traditional therapy of a vertebral osteochondrosis. "
4.	Lasers (Laser) 01/01/2002 - "[Mechanisms of therapeutic efficacy of magnetic laser irradiation of patients with neurological symptoms of lumbar osteochondrosis]." 10/01/2004 - "[Laser puncture in the treatment of reflectory manifestations of lumbosacral osteochondrosis in elderly patients in geriatric hospital]." 01/01/2001 - "[Percutaneous laser diskectomy in cervical osteochondrosis]." 07/01/2000 - "The use of osteoperiosteal electropuncture and laser puncture combined in a complex treatment of 162 patients with lumbosacral osteochondrosis resulted in dissipation or apparent decrement in clinical manifestations of the trouble. " 01/01/1994 - "[Microsurgical and endoscopic laser diskectomy in osteochondrosis of the lumbar spine]."
5.	Injections 01/01/2015 - "The results of this review found limited evidence that prolotherapy injections are a safe and effective treatment for Achilles tendinopathy, plantar fasciopathy and Osgood-Schlatter disease, however more robust research using large, methodologically-sound randomised controlled trials is required to substantiate these findings." 01/01/2015 - "These were then grouped according to tendinopathy or fasciopathy being treated with prolotherapy injections: Achilles tendinopathy, plantar fasciopathy and Osgood-Schlatter disease. " 01/01/2020 - "Letter to editor for: No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double‑blind study https://doi.org/10.1007/s00402-019-03297-2." 02/01/2020 - "No superiority of dextrose injections over placebo injections for Osgood-Schlatter disease: a prospective randomized double-blind study." 06/01/1988 - "[Treatment of reflex neurodystrophic syndromes of lumbar osteochondrosis using hydroxycobalamin injections]."