Spine Osteoarthritis

A degenerative joint disease involving the SPINE. It is characterized by progressive deterioration of the spinal articular cartilage (CARTILAGE, ARTICULAR), usually with hardening of the subchondral bone and outgrowth of bone spurs (OSTEOPHYTE).

Also Known As:

Networked: 55 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Low Back Pain (Lumbago)
3.	Osteoporosis
4.	Osteoarthritis
5.	Neurogenic Inflammation

Experts

1.	Shiraki, Masataka: 3 articles (11/2021 - 01/2007)
2.	Urano, Tomohiko: 3 articles (11/2021 - 01/2007)
3.	Suyasa, I Ketut: 3 articles (01/2019 - 02/2017)
4.	Lestari, Anak Agung Wiradewi: 2 articles (01/2019 - 11/2018)
5.	Cooper, Cyrus: 2 articles (02/2012 - 04/2005)
6.	Reginster, Jean-Yves: 2 articles (02/2012 - 12/2008)
7.	Hosoi, Takayuki: 2 articles (01/2007 - 01/2007)
8.	Inoue, Satoshi: 2 articles (01/2007 - 01/2007)
9.	Nakamura, Toshitaka: 2 articles (01/2007 - 01/2007)
10.	Narusawa, Ken'ichiro: 2 articles (01/2007 - 01/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spine Osteoarthritis:

1.	CalciumIBA 02/01/2018 - "The correlation is further improved by quantifying the degree of different confounding factors (osteoarthritis of the spine, body mass index and aortic calcium score) and taking these into account in an explanatory model. " 04/01/1991 - "Altogether 58 women were excluded from the final analysis due to significant spinal osteoarthritis or other diseases or drugs known to influence calcium or bone metabolism. " 02/01/2018 - "Furthermore, aortic calcium was measured as well as the presence of osteoarthritis of the spine (OAS) and osteoarthritis in facet joints (OAF) with a 5-grade scaling system. " 10/01/2008 - "Among 249 women consulting for either shoulder tendonitis or lumbar spine osteoarthritis, 121 free of conditions and drugs affecting bone and calcium metabolism completed two food-frequency questionnaires within 15 d and we selected the 85 subjects with retest scores within the +/- 15% of test scores. "
2.	Piroxicam (Feldene)FDA LinkGeneric 01/01/2009 - "The piroxicam patch is effective in the treatment of lumbar osteoarthritis and has demonstrated to be well tolerated and it improves patients compliance. " 01/01/2009 - "The piroxicam patch offers a comparable alternative to the marketed piroxicam cream for the treatment of lumbar osteoarthritis with the advantage of a better compliance with the once a day application of the patch compared to three daily applications for the piroxicam cream." 01/01/2009 - "In order to assess the efficacy and safety of a new patch containing 14 mg of piroxicam (CAS 36322-90-4) 1%, applied once daily, in comparison with a reference marketed formulation, piroxicam 1% cream applied three times a day, placebo patch applied once daily, a randomized, placebo-controlled, parallel-group clinical trial was carried out by general practitioners in patients with lumbar osteoarthritis aged between 18 and 75 years. " 01/01/2009 - "Efficacy and safety of piroxicam patch versus piroxicam cream in patients with lumbar osteoarthritis. " 10/01/1990 - "A clinical trial comparing a new NSAID (droxicam) and piroxicam in spinal osteoarthritis."
3.	strontium ranelate (protelos)IBA 03/01/2008 - "The aim of this study was to determine whether a 3-year treatment with strontium ranelate could delay the progression of spinal osteoarthritis (OA). " 12/01/2008 - "Preliminary results suggest that strontium ranelate is able to reduce the progression of spine osteoarthritis. " 03/01/2008 - "Effects of strontium ranelate on spinal osteoarthritis progression." 02/01/2012 - "Exploratory studies in the osteoporosis trials report that strontium ranelate reduces biomarkers of cartilage degradation, and attenuates the progression and clinical symptoms of spinal osteoarthritis, suggesting symptom- and structure-modifying activity in osteoarthritis. "
4.	Glucosamine (Dona)IBA 07/01/1997 - "Conservative management of spinal osteoarthritis with glucosamine sulfate and chiropractic treatment." 06/20/2013 - "To ascertain whether the use of oral glucosamine influences symptoms or functional outcomes in patients with chronic low back pain (LBP) thought to be related to spinal osteoarthritis (OA). " 09/01/2010 - "Six months' treatment with glucosamine does not reduce pain for patients with lower back pain and degenerative lumbar osteoarthritis, a study has revealed." 07/07/2010 - "Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial." 03/01/2011 - "To systematically search and assess the quality of the literature on the use of glucosamine, chondroitin sulfate, and methylsulfonylmethane for the treatment of spinal osteoarthritis / degenerative joint disease, and degenerative disc disease. "
5.	Biomarkers (Surrogate Marker)IBA 01/01/2010 - "Imaging biomarkers of spine osteoarthritis." 02/01/2012 - "Exploratory studies in the osteoporosis trials report that strontium ranelate reduces biomarkers of cartilage degradation, and attenuates the progression and clinical symptoms of spinal osteoarthritis, suggesting symptom- and structure-modifying activity in osteoarthritis. "
6.	Analgesics (Analgesic Drugs)IBA 06/01/2021 - "Therefore, in the context of neuropathic pain, mechanisms other than postural changes likely contribute to the analgesic effects of wearing postural insoles, in contrast to nociceptive pain due to spinal osteoarthritis." 09/07/1996 - "A double-blind randomized multicentric study was performed to test the hypothesis that the analgesic effect of paracetamol-cafeine is equivalent to that of paracetamol-dextropropoxyphen in patients suffering from pain due to osteoarthritis of the spine. "
7.	Trace Elements (Biometals)IBA 09/23/2022 - "The study showed some abnormalities in serum trace element levels and TAS in patients with osteoarthritis of the spine." 09/23/2022 - "Trace elements and antioxidant status may play an active role in the pathogenesis of osteoarthritis of the spine. "
8.	Substance PIBA 01/01/2019 - "This study aimed to investigate the association between naturally occurring spinal osteoarthritis (OA) (L3-L5), the expression of substance P (SP) centrally (L4-L5) and the presence of neurogenic inflammation within the neurosegmentally linked quadriceps (L2-L5) in elderly rats versus young controls. "
9.	Anesthetics (Anesthetic Agents)IBA 08/01/2006 - "Our study supports the selected use of hip anesthetic arthrograms in the preoperative assessment of patients with concurrent hip and lumbar spine osteoarthritis associated with nondiagnostic history and physical examinations."
10.	Acetaminophen (Paracetamol)FDA LinkGeneric 09/07/1996 - "A double-blind randomized multicentric study was performed to test the hypothesis that the analgesic effect of paracetamol-cafeine is equivalent to that of paracetamol-dextropropoxyphen in patients suffering from pain due to osteoarthritis of the spine. "

Therapies and Procedures

1.	Therapeutics 01/01/2022 - "The study was designed to assess short- and long-term effects of spa therapy administered to patients with osteoarthritis of the spine who received treatment in health resorts located in Poland. " 01/01/2022 - "Effects of complex spa therapy in patients with osteoarthritis of the spine receiving treatments in health resorts in south-eastern Poland." 10/01/2016 - "Therefore, we aimed to evaluate the short-term effects of spa therapy in patients aged 65 years and older with generalized, knee, hip, and cervical and lumbar spine osteoarthritis. " 01/01/2022 - "In conclusion spa therapy reduces pain, improves functional efficiency and increases the level of life satisfaction in patients with osteoarthritis of the spine. " 01/01/2019 - "Sulphurous mud-bath therapy for treatment of chronic low back pain caused by lumbar spine osteoarthritis."
2.	Physical Therapy Modalities (Physical Therapy Technique) 09/01/2012 - "The aim of our study was to assess the effect of the frequency of home exercise program (HEP) performance on pain [10-point visual analog scale (VAS)] in patients with osteoarthritis of the spine or knee after more than 6 months discharge from physical therapy (PT). "
3.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 11/09/2017 - "To identify the effects of hormone replacement therapy (HRT) on spinal osteoarthritis (OA). " 11/09/2017 - "Relationship between hormone replacement therapy and spinal osteoarthritis: a nationwide health survey analysis of the elderly Korean population."
4.	Knee Replacement Arthroplasty (Total Knee Replacement) 01/01/2023 - "In multivariate analyses, controlling separately for the effects of body mass index, total body bone mineral density, and smoking status, eight robust causal relationships remained: Muesli intake was negatively associated with knee osteoarthritis, spine osteoarthritis and total knee replacement. "
5.	Cryotherapy (Therapy, Cold) 01/01/2022 - "Effect of whole body cryotherapy on low back pain and release of endorphins and stress hormones in patients with lumbar spine osteoarthritis."