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Nephrogenic Fibrosing Dermopathy

A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.
Also Known As:
Dermopathies, Nephrogenic Fibrosing; Dermopathy, Nephrogenic Fibrosing; Fibroses, Nephrogenic Systemic; Fibrosing Dermopathies, Nephrogenic; Fibrosing Dermopathy, Nephrogenic; Fibrosis, Nephrogenic Systemic; Nephrogenic Fibrosing Dermopathies; Nephrogenic Systemic Fibroses; Systemic Fibroses, Nephrogenic; Systemic Fibrosis, Nephrogenic; Nephrogenic Systemic Fibrosis
Networked: 720 relevant articles (16 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Renal Insufficiency (Renal Failure)
2. Fibrosis (Cirrhosis)
3. Chronic Kidney Failure (Chronic Renal Failure)
4. Chronic Renal Insufficiency
5. Kidney Diseases (Kidney Disease)

Experts

1. Kay, Jonathan: 17 articles (12/2016 - 10/2007)
2. Cowper, Shawn E: 14 articles (05/2015 - 11/2003)
3. Thomsen, Henrik S: 12 articles (06/2016 - 09/2006)
4. Abraham, Jerrold L: 12 articles (11/2011 - 01/2007)
5. Perazella, Mark A: 12 articles (03/2011 - 05/2003)
6. Marckmann, Peter: 11 articles (11/2011 - 09/2006)
7. Pietsch, Hubertus: 10 articles (01/2017 - 01/2008)
8. Sieber, Martin A: 10 articles (01/2017 - 01/2008)
9. High, Whitney A: 10 articles (01/2013 - 01/2007)
10. Prince, Martin R: 9 articles (01/2019 - 09/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nephrogenic Fibrosing Dermopathy:
1. GadoliniumIBA
08/01/2010 - "The purpose of our study was to determine the efficacy of using the Choyke questionnaire to stratify the potential risk for nephrogenic systemic fibrosis (NSF) before a gadolinium-enhanced MRI examination and to compare the economic impact of such an approach with universal blood sampling before gadolinium-enhanced MRI. "
12/01/2023 - "Recently, many studies show a gadolinium deposition in different human organs due to release of free gadolinium various body organs or tissue, which led to increased concern about the use of gadolinium agents, in this study, the potential diseases that may affect the patient and side effects that appear on the patient and related to accumulation of gadolinium were clarified, the study focused on the organs such as brain and bones in which gadolinium deposition was found and the lesions associated with it, and the diseases associated with gadolinium retention includes Nephrogenic Systemic Fibrosis (NSF) and Gadolinium deposition disease (GDD). "
01/01/2020 - "This study aimed to analyze any nephrogenic systemic fibrosis-related risks and quantify skin gadolinium levels in patients with impaired renal function but without nephrogenic systemic fibrosis who had received gadobenate. "
05/01/2016 - "However, GBCA administration has been associated with increased occurrence of nephrogenic systemic fibrosis (NSF) in patients with severely compromised renal function, and several studies have shown evidence of gadolinium deposition in specific brain structures, the globus pallidus and dentate nucleus, in patients with normal renal function. "
01/01/2016 - "Dynamic contrast-enhanced MRI studies renal perfusion after gadolinium administration, with possible side effects, such as nephrogenic systemic fibrosis. "
2. Contrast MediaIBA
3. Imatinib Mesylate (Gleevec)FDA Link
4. gadodiamide (Omniscan)FDA Link
5. IronIBA
6. ErythropoietinFDA Link
7. gadobutrolIBA
8. ferryl iron (Fe(4+))IBA
9. sodium thiosulfateFDA Link
10. Tyrosine Kinase InhibitorsIBA

Therapies and Procedures

1. Renal Dialysis (Hemodialysis)
2. Therapeutics
3. Kidney Transplantation
4. Photopheresis
5. Plasmapheresis