|3.||Pathologic Constriction (Stenosis)
|5.||Intervertebral Disk Displacement (Herniated Disc)
|1.||van den Berg, W B: 10 articles (01/2016 - 02/2001)|
|2.||van der Kraan, P M: 8 articles (01/2016 - 02/2001)|
|3.||van der Kraan, Peter M: 5 articles (01/2013 - 07/2002)|
|4.||van den Berg, Wim B: 5 articles (01/2013 - 07/2002)|
|5.||Lafeber, F P J G: 4 articles (01/2016 - 11/2008)|
|6.||Blom, A B: 4 articles (01/2016 - 01/2004)|
|7.||van Lent, P L E M: 4 articles (01/2016 - 01/2004)|
|8.||Blaney Davidson, E N: 4 articles (06/2015 - 11/2006)|
|9.||Kraus, Virginia B: 4 articles (09/2014 - 06/2004)|
|10.||Kawaguchi, Hiroshi: 4 articles (01/2012 - 08/2006)|
|1.||Transforming Growth Factor beta (TGF-beta)IBA
07/01/2002 - "In conclusion, we show for the first time that endogenous TGF-beta is a crucial factor in the process of osteophyte formation and has an important function in protection against cartilage loss."
11/01/2006 - "Transforming growth factor-beta (TGFbeta) has been suggested to be associated with protection against cartilage damage and new cartilage formation as seen in osteophytes. "
10/01/2001 - "Studies with scavenging transforming growth factor beta soluble receptor identified endogenous transforming growth factor-beta involvement in spontaneous cartilage repair and chondrophyte and subsequent osteophyte formation in arthritic conditions. "
12/01/2007 - "Our findings demonstrate that the role of BMP during the onset of TGFbeta-induced and experimental OA-induced osteophyte formation is limited. "
12/01/2007 - "However, blocking BMP activity inhibited neither TGFbeta-induced nor experimental OA-associated osteophyte formation. "
03/01/2012 - "This finding was studied to determine if it would be helpful in identifying fusion on radiographs obtained in 148 patients who underwent an ACDF in which a PEEK cage was filled with local autograft bone (bone spurs in the present cases). "
01/01/2013 - "We present the design of the CASCADE trial on effectiveness of ceramic cages versus PEEK cages in patients with cervical disc herniation and/or osteophytes. "
07/01/2015 - "Twenty-six patients who underwent ACDF using a stand-alone PEEK cage packed with local osteophytes and cancellous allograft bone from January 2010 to January 2012 were enrolled in this study. "
11/01/2011 - "Self-locking stand-alone PEEK cages packed with excised local osteophytes and calcium sulfate are safe and effective. "
02/01/1997 - "Group III (tenidap-treated) dogs had a slightly reduced incidence of osteophytes compared with the group II (12-week OA) dogs (71% versus 100%), and the size of the osteophytes was significantly diminished (mean +/- SEM 1.75 +/- 0.69 mm versus 4.38 +/- 0.64 mm). "
05/01/1997 - "Dogs treated with tenidap at both 1.5 and 0.5 mg/kg bid exhibited a reduction in the size of osteophytes (2.25 +/- 0.30 mm, 1.70 +/- 0.65 mm, respectively) compared to the 12 weeks OA group (3.55 +/- 0.94 mm). "
09/01/1995 - "Compared with the untreated or omeprazole-treated OA groups, the dogs treated with tenidap exhibited significant reduction in the incidence (P < or = 0.001) and size (P < or = 0.0001) of osteophytes. "
05/01/2002 - "A voluminous anterior cervical osteophyte at the C5 level was diagnosed by computed tomography (CT) and barium swallow test and removed by an anterior approach to the cervical spine, with clinical remission. "
10/01/2015 - "Swallowing studies, such as modified barium swallow study and fiberoptic endoscopic evaluation of swallowing, may demonstrate a nonretroflexing epiglottis owing to cervical spine osteophytes or hardware, thus impeding pharyngeal bolus transit. "
09/01/2009 - "Extrinsic esophageal compression secondary to anterior cervical osteophytes was radiographically confirmed via preoperative barium esophagogram swallowing study. "
12/01/2015 - "Barium swallow demonstrated a large C4/C5 vertebral osteophyte. "
08/01/2003 - "Barium swallow showed compression and lateral displacement of the cervical tract of the esophagus, secondary to compression by a large osteophyte. "
|5.||diazenedicarboxylic acid bis(N'-methylpiperazide)IBA
04/01/1998 - "This study examined how often Heberden's nodes and radiological distal interphalangeal (DIP) osteophytes coexist in the same digit and the sensitivity, specificity, and positive predicative value of each for OA at different sites or generalised disease. "
06/01/2014 - "Radiographs showed osteophytes at the DIP joint in all affected digits. "
09/01/2011 - "Osteophytes at the DIP and PIP joints were also evaluated on lateral radiographs and compared to the findings on the antero-posterior radiographs. "
07/01/2010 - "Increase in JSN and osteophyte grade occurred most frequently in the DIP joints. "
07/01/2010 - "Radiographs of the distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints, and the first interphalangeal (IP1) and first carpometacarpal (CMC1) joints of both hands were read for joint space narrowing (JSN) and osteophytes according to the OARSI atlas. "
|6.||Adrenal Cortex Hormones (Corticosteroids)IBA
02/01/1989 - "Protective effects of corticosteroids on cartilage lesions and osteophyte formation in the Pond-Nuki dog model of osteoarthritis."
11/01/1985 - "Although corticosteroids have been shown to cause articular cartilage degeneration, recent studies of experimentally induced osteoarthritis indicate that under certain conditions they may protect against cartilage damage and osteophyte formation. "
|7.||Hyaluronic Acid (Hyaluronan)IBA
02/01/2013 - "Synovectomy, debridement or excision of chondral flaps and osteophytes under arthroscopy, as well as scheduled intraarticular sodium hyaluronate injection should be recommened to treat ankle degenerative osteoarthropathy."
04/01/2009 - "However, examination of the entire operative knee demonstrated a significantly greater extent of degenerative changes (synovial inflammation and osteophyte formation) in the control group than in both hyaluronic acid treatment groups (P < .05). "
04/01/2011 - "Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women."
08/01/2011 - "Baseline levels of serum cartilage oligomeric matrix protein (COMP), hyaluronan (HA), high-sensitivity C-reactive protein (hsCRP), and keratan sulfate (KS) and baseline and followup radiographs were available for 353 knees without baseline osteophyte formation and for 446 knees without baseline joint space narrowing (JSN). "
11/01/2012 - "(1) To determine associations between radiographic features of lumbosacral (LS) spine disc space narrowing (DSN) and osteophytes (OST) and joint metabolism biomarkers (serum cartilage oligomeric matrix protein (COMP), hyaluronic acid (HA), collagen neoepitope (C2C), C-propeptide of type II procollagen (CP-II), urine C-terminal cross-linking telopeptide (CTX-II) and N-terminal telopeptide (NTX-I)). "
|8.||Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
04/01/1999 - "A significant reduction in the width of osteophytes and size of macroscopic lesions (P < 0.04) was observed, and was dependent on the amount of IL-1Ra plasmid injected. "
09/01/1996 - "Recombinant human IL-1Ra exerted a dose-dependent protective effect on the development of osteophytes and cartilage lesions in vivo. "
|9.||Isotretinoin (Accutane)FDA LinkGeneric
01/01/2011 - "Endoscopic sinus surgery revealed osteophytes, most likely an isotretinoin-related adverse event, and post operatively the patient's sinus disease and skin disease both dramatically improved. "
10/01/1984 - "Bilateral 2.5 and 3.0 mm nasal bone osteophytes developed five weeks following the initiation of oral isotretinoin therapy (50 mg daily) for severe cystic acne vulgaris in a healthy 30-year-old white woman who had undergone uneventful rhinoplasty 12 years earlier. "
|10.||Omeprazole (Esomeprazole)FDA LinkGeneric
04/01/2009 - "Although some relevant papers report no significant difference in improved neurological deficit between patients treated surgically and those undergoing conservative therapy, we prefer surgical management, in most of the cases from the anterior approach, which allows us to remove dorsal osteophytes and perform careful decompression to prevent damage to nerve structures and to preserve those which are still intact. "
02/01/2014 - "There were 12 patients with compression of the spinal cord or nerve root caused by degenerative changes in adjacent segments of fusion segments, 4 cases in upper segments, and 8 cases in lower segments; 3 patients with compression of the spinal cord or nerve root caused by vertebral posterior osteophyte of decompressed segments; 1 patient with compression of the spinal cord caused by incomplete anterior decompression. "
01/01/2013 - "The patient underwent a unilateral posterior repair of his osteophyte with successful anterior decompression. "
04/20/2012 - "As a method of ACDF, indirect decompression through interbody height distraction and spontaneous posterior osteophyte resorption has the advantage of reducing complications that can occur during direct decompression. "
04/01/2012 - "All patients had arthroscopic ulnar nerve decompression, osteophyte resection, and capsulectomy during the same procedure. "
04/01/1995 - "This study retrospectively reviewed the clinical and radiographic results of a series of patients who underwent osteophyte resection during anterior discectomy and fusion. "
01/01/2015 - "Among the patients, osteophytes removal was performed in 3 cases, osteophytes removal with discectomy and fusion was performed in 2 cases, osteophytes removal with corpectomy and fusion was performed in 3 cases. "
10/01/2014 - "We defined a new grading system of plain radiographic evidence of degenerative changes in adjacent discs after anterior cervical discectomy and fusion using cervical plates; Grade 0 is considered normal, and Grade V consists the presence of posterior osteophytes and a decrease in disc height to less than 50% of normal. "
04/01/2014 - "After discectomy, osteophytes were removed with Piezosurgery to decompress the spinal canal and the foramina. "
04/01/2014 - "Use of Piezosurgery for removal of retrovertebral body osteophytes in anterior cervical discectomy."
04/01/2009 - "This gives the surgeon a simple way of planning where the hip center should be and may be particularly helpful in revision hip arthroplasty or in cases involving extensive osteophytes, dysplasia, or protrusio."
06/01/2010 - "Computer modeling of 10 patients' computed tomographic scans was used to study the variables affecting hip arthroplasty range of motion before bony impingement (ROMBI) including acetabular offset and height, femoral offset, height and anteversion, and osteophyte removal. "
04/01/2007 - "The goal of this study was to determine whether the degree of osteophyte formation was associated with the degree of cartilage loss and the patellofemoral symptoms and functions in osteoarthritic patients undergoing total knee arthroplasty (TKA). "
04/01/2015 - "In most cases of arthritic varus knees, stepwise osteophytes removal and medial soft tissue release could achieve satisfactory soft tissue balance during total knee arthroplasty. "
01/01/2015 - "At 3-year follow-up, knees were scored for change in joint space narrowing (JSN), osteophyte (OST) progression, or occurrence of total knee arthroplasty (TKA). "
02/01/1989 - "Operated dogs treated orally or with IA injections had a significant reduction in osteophyte size. "
01/01/2015 - "In this animal study, we investigated the in vivo effects of TA injections on macrophage activation, osteophyte development and joint degeneration. "
07/18/2014 - "But, there is no data that any of the IA injections will cause osteophytes to regress or cartilage and meniscus to regenerate in patients with substantial and irreversible bone and cartilage damage. "
09/01/2013 - "Here we seek to alleviate the cell leakage problem and the associated complication osteophyte formation by developing an injectable annulus plug to block the injection portal during intra-disc delivery. "
11/01/2012 - "Cartilage histopathologic scores and osteophyte size were evaluated at 1, 4, and 8 weeks post-injections. "
06/01/2014 - "The joint debridement, removal of loose body and osteophyte, plasty of articular cartilage, and plasma radiofrequency ablation of lateral and medial ligaments were performed. "
02/01/2014 - "Arthroscopic procedures performed included: synovectomy, debridement of osteophytes, removal of loose bodies, anterior and posterior capsulectomy, radial head excision. "
12/01/2013 - "Also, the debridement of the osteophytes or even a resurfacing of the patella may be a more definitive solution to such patellofemoral problems. "
02/01/2013 - "Follow procedures were involved in the surgery: synovectomy,debridement or excision of fragments of articular cartilage or chondral flaps and osteophytes that prevented full extension. "
12/01/2012 - "Arthroscopic debridement is a general term that is used to cover many procedures, including lavage, partial meniscectomy, removal of loose body, synovectomy, chondroplasty, removal of offending osteophytes, and/or microfracture. "