|1.||Rademaker, Miriam T: 22 articles (10/2015 - 10/2002)|
|2.||Richards, A Mark: 20 articles (03/2015 - 10/2002)|
|3.||Li, Shengnan: 16 articles (11/2015 - 06/2005)|
|4.||Charles, Christopher J: 13 articles (10/2015 - 10/2002)|
|5.||Petraglia, Felice: 13 articles (03/2012 - 08/2002)|
|6.||Stephanou, Anastasis: 10 articles (11/2014 - 03/2002)|
|7.||Scarabelli, Tiziano M: 10 articles (11/2014 - 07/2002)|
|8.||Jin, Lai: 9 articles (11/2015 - 08/2009)|
|9.||Takahashi, Kazuhiro: 8 articles (04/2014 - 01/2002)|
|10.||Florio, Pasquale: 8 articles (09/2011 - 08/2002)|
09/17/2002 - "Urocortin is a novel cardioprotective agent that can protect cardiac myocytes from the damaging effects of ischemia/reperfusion both in culture and in the intact heart and is effective when given at reperfusion. "
06/01/2005 - "Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts."
01/01/2004 - "These results suggest that ischemia-reperfusion impairs the coronary vasodilation to urocortin and produces endothelial dysfunction and that this endothelial dysfunction may be improved by urocortin."
03/19/2008 - "This study evaluates whether cardiac ischemia induces release of urocortin, before and independently from myocyte cell death. "
01/01/2004 - "To study whether urocortin also protects coronary endothelial function during ischemia-reperfusion, hearts from Sprague-Dawley rats were perfused at constant flow and then exposed to 15 mins ischemia followed by 15 mins reperfusion. "
06/01/2005 - "In vivo protective effects of urocortin on ischemia-reperfusion injury in rat heart via free radical mechanisms."
12/01/2014 - "Recent studies have shown that urocortins exert various biological effects in the cardiovascular system, such as vasodilation, positive inotropic and lusitropic effects, as well as cardioprotection against ischemia-reperfusion injury. "
01/01/2012 - "Recent studies have shown that urocortins have various biological actions in the cardiovascular system, such as a vasodilator action, a positive inotropic action, a cardioprotective action against ischemia/reperfusion injury, and suppressive actions against the renin angiotensin system and the sympathetic nervous system. "
06/01/2005 - "The aim of this study was to investigate the effects of urocortin (UCN) on oxidative stress and the mechanisms of urocortin on ischemia-reperfusion injury in vivo in the rat model. "
11/01/2009 - "We previously reported that iatrogenic ischemia/reperfusion injury caused myocyte induction of urocortin, an endogenous cardioprotective peptide. "
01/01/2011 - "Urocortin 2 is beneficial in heart failure, but the underlying cellular mechanisms are not completely understood. "
10/01/2013 - "Urocortin-2 infusion in acute decompensated heart failure: findings from the UNICORN study (urocortin-2 in the treatment of acute heart failure as an adjunct over conventional therapy)."
06/01/2011 - "In the current study, we administered a 4-day infusion of a vehicle control (0.9% saline; n=6) or urocortin 2 (0.75 μg/kg per hour; n=6) to sheep with pacing-induced heart failure. "
08/01/2010 - "Indeed, a number of studies have demonstrated increased urocortin activity in experimental and clinical heart failure, with apparent augmented responses in these states. "
04/01/2007 - "Safety trials for intravenous urocortin treatment have already begun for the treatment of congestive heart failure. "
10/01/2003 - "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes."
08/01/2004 - "The aim of this study was to determine the effect of in vitro hypoxia on human trophoblastic urocortin production. "
11/15/2009 - "The human urocortin 2 gene is regulated by hypoxia: identification of a hypoxia-responsive element in the 3'-flanking region."
08/01/2004 - "The effect of hypoxia on placental urocortin production is not known. "
08/01/2004 - "Effect of hypoxia on urocortin production in human gestational trophoblasts in vitro."
03/01/2015 - "Chronic urocortin 2 administration improves cardiac function and ameliorates cardiac remodeling after experimental myocardial infarction."
03/01/2015 - "The impact of chronic urocortin 2 (Ucn2) treatment after myocardial infarction (MI) has not previously been investigated. "
10/01/2010 - "Despite its proposed cardioprotective effect, the role of plasma urocortin in acute myocardial infarction (AMI) remains unknown. "
10/01/2010 - "Plasma urocortin in acute myocardial infarction patients."
07/21/2008 - "This growing evidence suggests that urocortins may have a prognostic value as well as being a potential therapeutic treatment for heart failure and myocardial infarction patients. "
|1.||Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)
|6.||Acetylcholine (Acetylcholine Chloride)
|7.||Caspase 3 (Caspase-3)
|8.||HMGB1 Protein (HMG1)
|9.||Atrial Natriuretic Factor (ANF)