Urocortins

Neuropeptides of about 40 amino acids which are structurally similar to CORTICOTROPIN-RELEASING FACTOR. Unlike CRF acting primarily through type 1 CRF RECEPTORS, urocortins signal preferentially through type 2 CRF receptors. Urocortins have wide tissue distribution from fish to mammals, and diverse functions. In mammals, urocortins can suppress food intake, delays gastric emptying, and decreases heat-induced edema.

Also Known As:

Networked: 349 relevant articles (26 outcomes, 56 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rademaker, Miriam T: 23 articles (01/2022 - 10/2002)
2.	Richards, A Mark: 21 articles (11/2017 - 10/2002)
3.	Li, Shengnan: 17 articles (11/2016 - 06/2005)
4.	Petraglia, Felice: 15 articles (03/2018 - 08/2002)
5.	Charles, Christopher J: 12 articles (10/2015 - 10/2002)
6.	Scarabelli, Tiziano M: 11 articles (05/2019 - 07/2002)
7.	Jin, Lai: 10 articles (11/2016 - 08/2009)
8.	Stephanou, Anastasis: 10 articles (11/2014 - 03/2002)
9.	Bhargava, Aditi: 9 articles (01/2019 - 05/2005)
10.	Chen-Scarabelli, Carol: 8 articles (05/2019 - 09/2004)

Related Diseases

1.	Ischemia 06/01/2005 - "Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts." 01/01/2004 - "These results suggest that ischemia-reperfusion impairs the coronary vasodilation to urocortin and produces endothelial dysfunction and that this endothelial dysfunction may be improved by urocortin." 10/14/2016 - "The objective of this study was to investigate the role of urocortin in testicular apoptosis using an experimental ischemia-reperfusion rat model. " 03/19/2008 - "This study evaluates whether cardiac ischemia induces release of urocortin, before and independently from myocyte cell death. " 01/01/2004 - "To study whether urocortin also protects coronary endothelial function during ischemia-reperfusion, hearts from Sprague-Dawley rats were perfused at constant flow and then exposed to 15 mins ischemia followed by 15 mins reperfusion. "
2.	Reperfusion Injury 12/01/2014 - "Recent studies have shown that urocortins exert various biological effects in the cardiovascular system, such as vasodilation, positive inotropic and lusitropic effects, as well as cardioprotection against ischemia-reperfusion injury. " 06/01/2005 - "The aim of this study was to investigate the effects of urocortin (UCN) on oxidative stress and the mechanisms of urocortin on ischemia-reperfusion injury in vivo in the rat model. " 01/01/2018 - "Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury." 01/01/2018 - "Acting through a variety of downstream mechanisms, urocortin has been shown to alter cellular metabolism and modulate the mechanism of cell death occurring as a result of ischemia-reperfusion injury. " 01/01/2016 - "Urocortin has the potential to improve acute cardiac dysfunction, as well as to reduce the myocardial damage sustained after ischemia reperfusion injury. "
3.	Heart Failure 01/01/2011 - "Urocortin 2 is beneficial in heart failure, but the underlying cellular mechanisms are not completely understood. " 10/01/2016 - "These data provide further evidence to suggest that urocortins 2 and 3 continue to hold promise for the treatment of heart failure." 08/01/2010 - "Indeed, a number of studies have demonstrated increased urocortin activity in experimental and clinical heart failure, with apparent augmented responses in these states. " 04/01/2007 - "Safety trials for intravenous urocortin treatment have already begun for the treatment of congestive heart failure. " 10/16/2002 - "The goal of this study was to determine the bioactivity of urocortin (Ucn) in experimental heart failure (HF). "
4.	Hypoxia (Hypoxemia) 08/01/2004 - "The aim of this study was to determine the effect of in vitro hypoxia on human trophoblastic urocortin production. " 08/01/2017 - "CRF and urocortin 3 protect the heart from hypoxia/reoxygenation-induced apoptosis in zebrafish." 08/01/2004 - "The effect of hypoxia on placental urocortin production is not known. " 08/01/2004 - "Effect of hypoxia on urocortin production in human gestational trophoblasts in vitro." 08/30/2010 - "Inhibition of Src by PP2 also reduced urocortin's protective effects in HL-1 cells after hypoxia/reoxygenation (H/R), as assessed by flow cytometry and caspase-3 activation assay. "
5.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2017 - "miR-125a, miR-139 and miR-324 contribute to Urocortin protection against myocardial ischemia-reperfusion injury." 01/01/2018 - "We present here an updated review largely focused on the various mechanisms through which urocortin alters cellular metabolism, and discuss the clinical potential of urocortin's cardioprotective ability in myocardial ischemia-reperfusion injury." 01/01/2018 - "Cardioprotective Utility of Urocortin in Myocardial Ischemia- Reperfusion Injury: Where do We Stand?" 01/01/2017 - "Urocortin 1 and 2 (Ucn-1 and Ucn-2) have established protective actions against myocardial ischemia-reperfusion (I/R) injuries. " 07/21/2008 - "Urocortins in heart failure and ischemic heart disease."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Corticotropin-Releasing Hormone Receptors (Corticotropin Releasing-Hormone Receptor)
3.	Corticotropin-Releasing Hormone
4.	Neuropeptides
5.	Ligands
6.	Adrenomedullin
7.	Acetylcholine (Acetylcholine Chloride)
8.	Urotensins
9.	Cardiotonic Agents (Cardiac Stimulants)
10.	triciribine

Related Therapies and Procedures

1.	Injections
2.	Glycemic Control
3.	Therapeutics
4.	Punctures
5.	Ligation