Phytochelatins

Poly-glutathione peptides composed of (Glu-Cys)n-Gly where n is two to seven. They are biosynthesized by glutathione gamma-glutamylcysteinyltransferase and are found in many PLANTS; YEASTS; and algae. They sequester HEAVY METALS.

Also Known As:

Networked: 8 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Banerjee, Aditya: 1 article (01/2021)
2.	Roychoudhury, Aryadeep: 1 article (01/2021)
3.	Kim, Hyun Soo: 1 article (12/2015)
4.	Kim, Yeo Jin: 1 article (12/2015)
5.	Seo, Young Rok: 1 article (12/2015)
6.	Babula, Petr: 1 article (04/2015)
7.	Hedbavny, Josef: 1 article (04/2015)
8.	Klejdus, Bořivoj: 1 article (04/2015)
9.	Kováčik, Jozef: 1 article (04/2015)
10.	Soares, Maria Elisa: 1 article (04/2015)

Related Diseases

1.	Wounds and Injuries (Trauma) 01/01/2004 - "Intracellular GSH and GSH-derived phytochelatins hinder the progression of heavy metal-initiated cell injuries by chelating and sequestering the metal ions themselves and/or by eliminating reactive oxygen species. " 01/01/2021 - "Accumulation of proline, anthocyanins, non-protein thiols and phytochelatins was stimulated for systemic protection against reactive oxygen species (ROS) and xenobiotic-mediated injuries during lead-fluoride toxicity. "
2.	Neoplasms (Cancer) 12/01/2015 - "Thus, we might think phytochelatin molecules and antioxidative phytochemical substances are helpful for prevention of heavy metal-induced cancer. "
3.	Infections 10/01/2012 - "While all organisms require sulfurous amino acids, plants require specialized sulfur-containing metabolites, such as glucosinolates and allylsulfur compounds, for protection from herbivory and microbial infection; and the synthesis of specialized peptides (i.e., glutathione and phytochelatins) for protection against reactive oxygen species and exposure to transition metals, such as cadmium. "
4.	Hypersensitivity (Allergy) 06/15/1999 - "Schizosaccharomyces pombe cells disrupted in the PCS gene exhibit hypersensitivity to Cd2+ and Cu2+ and are unable to synthesize phytochelatins upon Cd2+ exposure as determined by HPLC analysis. " 01/01/1997 - "A mutant that harbored a mutation in hmt1, the gene encoding an ATP-binding cassette-type transporter for vacuolar sequestration of a phytochelatin/Cd complex, exhibited only mild hypersensitivity to DDP even though it was 100-fold more sensitive to Cd. "
5.	Tetraploidy 04/01/2015 - "Soluble phenols, lignin, non-protein thiols, individual thiols (glutathione and phytochelatin 2) and ascorbic acid responded to high Cr(III) similarly in both cultivars while decrease of minerals was more pronounced in tetraploid ones. "

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Heavy Metals
3.	Sulfhydryl Compounds (Thiols)
4.	Proteins (Proteins, Gene)
5.	Glutathione (Reduced Glutathione)
6.	Phytochemicals
7.	Xenobiotics
8.	Sulfur
9.	Proline (L-Proline)
10.	Peptides (Polypeptides)