Thionins

Antimicrobial peptides of 45-47 amino acids and typically with four disulfide bridges. They are found in PLANTS. Type-V thionins lack the C-terminal nonapeptide. This should not be confused with thionine.

Also Known As:

Networked: 80 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	López-Meza, Joel E: 5 articles (01/2020 - 03/2008)
2.	Ochoa-Zarzosa, Alejandra: 5 articles (01/2020 - 03/2008)
3.	Zhang, Min: 4 articles (09/2018 - 07/2007)
4.	Li, Wen-Bin: 3 articles (03/2012 - 02/2007)
5.	Sun, Xiao-Cai: 3 articles (03/2012 - 02/2007)
6.	Guillaud, Martial: 2 articles (05/2021 - 04/2016)
7.	MacAulay, Calum: 2 articles (05/2021 - 04/2016)
8.	Báez-Magaña, Marisol: 2 articles (01/2020 - 04/2018)
9.	Medina-Estrada, Ivan: 2 articles (01/2020 - 04/2016)
10.	Hu, Yu-Yan: 2 articles (09/2018 - 03/2012)

Related Diseases

1.	Infarction (Infarctions) 02/01/2014 - "The increase in survival and improved functional outcomes are accompanied by a reduction in infarct volume, as determined by thionin staining of brain sections. " 01/01/2023 - "Brains were removed after 72 h and infarct volume was assessed via thionin staining, and RXFP1 expression, leukocyte infiltration and apoptosis were determined by immunofluorescence. " 08/01/2012 - "Infarct volumes were measured in thionin-stained brain sections. " 11/01/1999 - "Infarct volume was measured 96 hours later by computer-assisted planimetry in thionin-stained brain sections. " 10/15/1997 - "Infarct volume (cubic millimeters) was assessed 24 hr later in thionin-stained brain sections. "
2.	Hemolysis 01/01/1989 - "thionin of 1.6 microM for erythrocyte hemolysis and a binding constant of 2.1 microM (Osorio e Castro, V. R. " 01/01/1989 - "thionin is inactive, it was used as an inhibitor of hemolysis catalyzed by native P. " 01/01/1989 - "thionin (23% compared to 35% hemolysis by P. " 08/01/1989 - "The general response of cells to Pyrularia thionin involves a membrane alteration leading to depolarization and a channel-mediated influx of Ca2+. There is a related activation of phospholipase A2 that results in loss of membrane integrity, hemolysis in the case of erythrocytes, and eventually cell death. " 08/01/1989 - "Graded iodination of Pyrularia thionin leads to a related loss of activity for hemolysis, phospholipase A2 activation, cytotoxicity, and lethality in mice. "
3.	Prostatic Neoplasms (Prostate Cancer) 04/01/2016 - "Images of Feulgen-thionin-stained prostate cancer tissue microarray constructed from the surgical specimens of 33 prostate cancer patients were acquired for this study. " 04/01/2016 - "In this paper we present a new method to automatically localize thionin-stained prostate cancer cells, enabling the extraction of various nuclear and cell sociology features with high precision."
4.	Leukemia 04/23/2023 - "This study shows that defensin γ-thionin (Capsicum chinense) is cytotoxic to the K562 leukemia cells with an IC50 = 290 μg/mL (50.26 μM) but not for human peripheral blood mononuclear cells. "
5.	Neoplasms (Cancer) 11/01/2005 - "Finally, gamma-thionins activity has also been studied for future drug development, capable of inhibit tumor cell growth in human beings." 04/01/1980 - "AFP could be demonstrated in tumor tissue by immune histochemistry in one case only; HBs-Ag could never been shown by the aldehyd-thionin method. " 01/01/2023 - "Reports from our group showed that plant antimicrobial peptides (PAPs) PaDef from avocado and γ-thionin from habanero pepper are cytotoxic on cancer cells. " 12/31/2021 - "Viscotoxin A3 (VtA3) is the thionin from mistletoe (Viscum album) demonstrating antimicrobial and cytotoxic activity against cancer cells in vitro. " 03/01/1999 - "Extracts from European mistletoe (Viscum album L.) are applied in adjuvant cancer treatment, and some components, especially the mistletoe lectins (ML) have been immunologically characterised, but not the thionins, termed viscotoxins (VT). "

Related Drugs and Biologics

1.	Defensins
2.	Peptides (Polypeptides)
3.	Phospholipases A2 (Phospholipase A2)
4.	Phospholipases (Phospholipase)
5.	Phosphatidylcholines (Phosphatidylcholine)
6.	Oxygen (Dioxygen)
7.	Lipoxygenase (Lipoxygenase-1)
8.	Fatty Acids (Saturated Fatty Acids)
9.	Bee Venoms (Bee Venom)
10.	Periodic Acid

Related Therapies and Procedures

1.	Therapeutics