Histatins

03/01/2004 - "Initial clinical studies are encouraging, having demonstrated the safety and efficacy of histatin preparations in blocking the adherence of the yeast Candida albicans to denture acrylic, retarding plaque formation and reducing the severity of gingivitis. "
02/01/2002 - "Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis: a phase-2 multi-center study."
08/01/2022 - "Poisson Regression showed that: 1) CP and gingivitis influenced the degradation of histatin 1 and 5 (p < 0.05); 2) The degradation of histatin 5 was influenced by age and male sex (p < 0.05); and 3) GI influenced significantly the degradation of histatin 1 (p < 0.001). "
12/01/2002 - "The aims of the present double-blinded, randomized, controlled clinical trial were to evaluate the safety and toxicity of three histatin (P-113) concentrations in gel formulations, and to assess potential clinical benefit on the development of gingivitis (partial mouth design). "
05/01/2001 - "Clinical and microbial evaluation of a histatin-containing mouthrinse in humans with experimental gingivitis."

01/01/2022 - "Salivary Histatin 5 Level in Women with Vaginal Candidiasis."
04/26/2021 - "Therefore, the results of this study suggest that a deficiency of the antimicrobial peptide histatin 5 could possibly induce oral Candida infection in DS."
01/01/2015 - "Candida albicans is a major etiological organism for oropharyngeal candidiasis (OPC), while salivary histatin 5 (Hst 5) is a human fungicidal protein that protects the oral cavity from OPC. "
01/01/2015 - "Salivary protein histatin 5 (Hst 5) is fungicidal toward Candida albicans, the causative agent of oropharyngeal candidiasis. "
12/01/2000 - "Salivary histatins (Hsts) are antifungal peptides with promise as therapeutic agents against candidiasis. "

01/01/2014 - "Histatin 5-spermidine conjugates have enhanced fungicidal activity and efficacy as a topical therapeutic for oral candidiasis."
05/22/2009 - "Candida albicans, which is killed by histatins, induces oral candidiasis in individuals with compromised immune systems. "
01/01/1999 - "Such a finding suggests that oral candidiasis may modulate the levels of salivary histatin."
01/01/1999 - "These findings indicate that oral candidiasis is associated with increased levels of salivary histatin. "
01/01/1999 - "The level of salivary histatins was evaluated in 20 patients with a history of recurrent oral candidiasis and in age-, sex-matched healthy controls. "

11/01/2019 - "Histatin, a salivary protein, affects oral homeostasis through preservation of tooth integrity and protection against caries and fungal infections. "
07/01/2010 - "The human antimicrobial peptide has been proposed to represent an important lead for new generation of antimicrobial compounds for the treatment of oral mycoses, thus the information from the non-human primates histatins studied may aid strategies for drugs design."
03/01/2004 - "Their mode of action is distinct from those exhibited by the conventional azole and polyene drugs, hence histatins may have applications in controlling drug-resistant fungal infections. "
03/01/2004 - "Histatins may represent a new generation of antimicrobial compounds for the treatment of oral fungal infections and have the advantage, compared with conventional antifungal agents, of being a normal component of human saliva with no apparent adverse effects on host tissues and having a mode of action distinct to azole and polyene antifungals."
03/01/2004 - "The possibility of utilising histatins for the control of fungal infections of the oral cavity is being actively pursued with the antifungal properties of topical histatin preparations and histatin-impregnated denture acrylic being evaluated. "

01/01/2014 - "Salivary histatins in vitro promote wound closure by enhancing cell spreading and cell migration, but do not stimulate cell proliferation. "
01/01/2013 - "Members of the salivary histatin family promote wound closure in vitro by enhancing cell spreading and cell migration. "
11/01/2009 - "Here we report that histatin enhances reepithelialization in a human full-skin wound model closely resembling normal skin. "
09/01/2009 - "These findings encourage the future therapeutic application of histatins in the treatment of all kinds of wounds."
09/01/2009 - "Furthermore, we found that histatins stimulated wound closure of (primary) cells of both oral and non-oral origin. "