Cecropins

Antimicrobial peptides that form channels in membranes that are more permeable to anions than cations. They resemble MAGAININS, with their N-terminal region forming a positively charged amphipathic alpha helix, but containing an additional C-terminal segment.

Also Known As:

Networked: 100 relevant articles (6 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shen, Juan: 4 articles (07/2019 - 08/2011)
2.	Chu, Fujiang: 2 articles (01/2021 - 04/2010)
3.	Jin, Xiaobao: 2 articles (01/2021 - 04/2010)
4.	Lu, Xuemei: 2 articles (01/2021 - 04/2010)
5.	Jin, Fengliang: 2 articles (01/2015 - 06/2007)
6.	Xu, Xiaoxia: 2 articles (01/2015 - 06/2007)
7.	Lanz-Mendoza, Humberto: 2 articles (03/2014 - 01/2011)
8.	Kim, Chang-Hyun: 2 articles (06/2013 - 08/2011)
9.	Muturi, Ephantus J: 2 articles (06/2013 - 08/2011)
10.	Chu, Fu-jiang: 2 articles (01/2013 - 08/2011)

Related Diseases

1.	Septic Shock (Toxic Shock Syndrome) 08/14/2018 - "Anti-inflammatory activities of Aedes aegypti cecropins and their protection against murine endotoxin shock." 09/01/2001 - "Effect of mono-dose intraperitoneal cecropins in experimental septic shock." 09/01/2001 - "Mono-dose cecropin treatment prevents bacterial growth, endotoxemia, and mortality in rats with septic shock. " 09/01/2001 - "To investigate the efficacy of three cecropins, cecropin A, cecropin B, and cecropin P1, in preventing lethality in a rat model of septic shock. "
2.	Neoplasms (Cancer) 01/01/2014 - "The present study confirmed tumor-inhibitory effects of cecropin in vivo, and furthermore strongly suggested that cecropin cytotoxicity in BEL-7402 cells in vivo may be mainly derived from its pro-apoptotic action. " 01/01/2014 - "Specifically, we found that cecropin exerted no obvious side effects in tumor-bearing mice as it had no significant hematoxicity as well as visceral toxicity. " 01/01/2013 - "We found that Musca domestica cecropin inhibited the adhesion and migration of BEL-7402 cells, which also displayed curling microvilli, increased ball structures on cell surface, gradually broken connections between tumor cells, and even disappeared microvilli on some cells. " 10/01/2003 - "The cecropins possess effective anti-tumor activity with no cytotoxicity against normal eukaryotic cells, and impede the neoplastic process in murine large intestines." 10/01/2003 - "There was a significantly lower incidence of large intestinal tumors in rats gavaged with cecropins (65%, P<0.01), but the tumor burden (tumors/tumor-bearing animal) and tumor mass index were comparable between the groups (P>0.05). "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 03/03/2008 - "Both Cecropins induced an increase in LDH release from bladder tumor cells whereas benign fibroblasts were not affected. " 03/03/2008 - "This study evaluated the cytotoxic and antiproliferative efficacy of two well-characterized members of the Cecropin-family of antimicrobial peptides against bladder tumor cells and benign fibroblasts. " 03/03/2008 - "The antiproliferative and cytotoxic potential of the Cecropins A and B was quantified by colorimetric WST-1-, BrdU- and LDH-assays in four bladder cancer cell lines as well as in murine and human fibroblast cell lines. " 03/03/2008 - "Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells."
4.	Wounds and Injuries (Trauma) 06/01/2007 - "Insect cecropins are small basic polypeptides synthesized in fat body and hemocytes in response to bacterial infections or hypodermic injuries. " 10/01/2018 - "Efficacy of designer K11 antimicrobial peptide (a hybrid of melittin, cecropin A1 and magainin 2) against Acinetobacter baumannii-infected wounds." 01/01/2019 - "Antimicrobial peptides of multicellular organisms were first characterized in the 1980s by investigators who felt that known systems of immunity could not explain what they observed: the resistance to bacterial infection of a Cecropia moth pupa lacking antibodies or lymphocytes (cecropins (Steiner 1981)), the potent microbicidal activity of neutrophils from a rabbit (defensins (Selsted et al. 1985)), and the healing of a wound on the skin of the African clawed frog without infection in a non-sterile aquarium (magainins (Zasloff 1987)). "
5.	Diarrhea 06/01/2012 - "The incidence of diarrhea post-challenge in the antibiotic and cecropin AD treatments decreased compared with the control piglets. " 07/01/2019 - "Our objective was to investigate whether a thermostable protein fraction (TPF) obtained from the larvae of Musca domestica, which contains cecropin family AMPs, is effective in treating senna leaf (Folium Sennae)-induced diarrhea in mice and its possible underlying mechanism. "

Related Drugs and Biologics

1.	Antimicrobial Peptides
2.	Peptides (Polypeptides)
3.	Magainins
4.	Insecta cecropin B protein
5.	Proteins (Proteins, Gene)
6.	Melitten (Melittin)
7.	cecropin A
8.	Senna Extract
9.	cecropin P1-LI
10.	Defensins

Related Therapies and Procedures

1.	Therapeutics
2.	Subcutaneous Injections