Magainins

A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.

Also Known As:

Networked: 53 relevant articles (4 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cirioni, Oscar: 4 articles (11/2005 - 01/2002)
2.	Giacometti, Andrea: 4 articles (11/2005 - 01/2002)
3.	Scalise, Giorgio: 4 articles (11/2005 - 01/2002)
4.	Andrès, E: 3 articles (06/2012 - 09/2004)
5.	Kamysz, Wojciech: 3 articles (11/2005 - 09/2004)
6.	Silvestri, Carmela: 3 articles (11/2005 - 09/2004)
7.	Ghiselli, Roberto: 3 articles (02/2005 - 01/2002)
8.	Mocchegiani, Federico: 3 articles (02/2005 - 01/2002)
9.	Orlando, Fiorenza: 3 articles (02/2005 - 01/2002)
10.	Saba, Vittorio: 3 articles (02/2005 - 01/2002)

Related Diseases

1.	Infections 11/20/2020 - "Investigating the mechanism of action of magainin can help understand how to effectively fight off infection. " 04/01/2000 - "In publications dealing with the surgical technique of oocyte removal, the frogs' robust constitution and resistance against infections provided by magainins are pointed out. " 03/01/2001 - "Magainins are a group of short peptides originally isolated from frog skin and thought to function as a natural defense mechanism against infection due to their antimicrobial properties. " 11/01/1990 - "Magainins, antimicrobial peptides secreted by granular glands of frog skin, may be related to the high resistance to infections of this epithelial surface. " 09/01/1998 - "In July 1998, Magainin filed an NDA with the US FDA for the treatment of infections in diabetic foot ulcers [292671]. "
2.	Wounds and Injuries (Trauma) 10/01/2018 - "Efficacy of designer K11 antimicrobial peptide (a hybrid of melittin, cecropin A1 and magainin 2) against Acinetobacter baumannii-infected wounds." 01/01/2019 - "Antimicrobial peptides of multicellular organisms were first characterized in the 1980s by investigators who felt that known systems of immunity could not explain what they observed: the resistance to bacterial infection of a Cecropia moth pupa lacking antibodies or lymphocytes (cecropins (Steiner 1981)), the potent microbicidal activity of neutrophils from a rabbit (defensins (Selsted et al. 1985)), and the healing of a wound on the skin of the African clawed frog without infection in a non-sterile aquarium (magainins (Zasloff 1987)). "
3.	Septic Shock (Toxic Shock Syndrome) 01/01/2002 - "Single-dose intraperitoneal magainins improve survival in a gram-negative-pathogen septic shock rat model." 02/01/2005 - "To investigate the efficacy of pexiganan, a 22-residue magainin analog, alone and combined with betalactmas antibiotics in three experimental rat models of Gram-negative septic shock. " 01/01/2002 - "The therapeutic efficacies of three polycationic peptides selected among the class of the magainins (magainin I, magainin II, and magainin II amide), alone and combined with piperacillin, were investigated in a rat model of septic shock. "
4.	Sepsis (Septicemia) 09/01/2004 - "Therapeutic efficacy of the magainin analogue MSI-78 in different intra-abdominal sepsis rat models."
5.	Neoplasms (Cancer) 07/01/2006 - "Recent studies have also reported a significant antitumor effect of magainin II against various cancer cell lines and tumor mice models. " 05/01/1991 - "Magainins represent a natural cytolytic agent in vertebrates and may provide another therapeutic strategy for certain tumors." 05/01/1991 - "Here we show that magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor target cells with a relative cytotoxic potency that parallels their antibacterial efficacy and at concentrations that are relatively nontoxic to well-differentiated cells. " 07/01/2000 - "The hypothesis that timed application of a potent anti-microbial, anti-tumor agent like magainin peptides can inhibit blastocyst implantation was examined in the present study using the rhesus monkey as the primate model. " 05/01/2013 - "Of these peptides, magainin II (MG2) exhibited cytotoxicity in tumor cells only at high concentrations, likely due to the inefficiency of MG2 in cell membrane binding and cell entry. "

Related Drugs and Biologics

1.	Antimicrobial Peptides
2.	pexiganan
3.	Peptides (Polypeptides)
4.	Cecropins
5.	Melitten (Melittin)
6.	Anti-Bacterial Agents (Antibiotics)
7.	Amides
8.	Defensins
9.	Cathelicidins
10.	Histatins

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Administration
3.	Intraperitoneal Injections
4.	Intravaginal Administration