|1.||Cocco, Lucio: 5 articles (01/2007 - 05/2002)|
|2.||Martelli, Alberto M: 4 articles (01/2007 - 05/2002)|
|3.||Wu, Dianqing: 3 articles (08/2009 - 09/2003)|
|4.||Faenza, Irene: 3 articles (01/2007 - 05/2002)|
|5.||Manzoli, Lucia: 3 articles (01/2007 - 05/2002)|
|6.||Cocco, L: 2 articles (05/2012 - 06/2004)|
|7.||Manzoli, L: 2 articles (05/2012 - 06/2004)|
|8.||Benati, Donatella: 2 articles (06/2009 - 03/2008)|
|9.||Merigo, Flavia: 2 articles (06/2009 - 03/2008)|
|10.||Osculati, Francesco: 2 articles (06/2009 - 03/2008)|
03/01/2000 - "We conclude that altered protein expression and stoichiometry of the major cardiomyocyte Ca2+ cycling proteins rather than reduced phospholipase C beta 1 activation may contribute to improved mechanical function produced by left ventricular assist device support in human heart failure."
03/10/1998 - "Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction."
|2.||Multiple Endocrine Neoplasia Type 1 (MEN I)
01/01/1997 - "In this study, the structure and expression of the PLC beta 3 gene in MEN 1 patients were investigated in more detail, to determine its potential role in MEN 1 tumorigenesis. "
12/01/1995 - "For clarification of the role of PLC beta 3 in MEN 1 parathyroid tumorigenesis further study of this protein is required."
01/01/1997 - "In conclusion, these results exclude the PLC beta 3 gene as a candidate gene for MEN 1."
01/01/1997 - "To detect possible point mutations, or other small structural aberrations, direct sequencing of PLC beta 3 cDNAs from two affected persons from two different MEN 1 families was performed, but no MEN 1-specific abnormalities were revealed. "
01/01/1997 - "Our previous attempts to identify the MEN1 gene have resulted in the isolation of the phospholipase C beta 3 gene from the actual region. "
01/01/1996 - "Finally, the assignment of the PLC beta 1 gene to the band q35-36 of rat chromosome 3 paves the way for further genetic studies given the fact that the region where PLC beta 1 gene maps is a hot spot for genetic alterations in a number of experimentally induced rat tumors. "
08/04/2009 - "Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5."
12/01/1995 - "Parathyroid PLC beta 3 invariably was homogeneously expressed, and this included even MEN 1 patients with reduced PLC beta 3 expression in endocrine pancreatic tumors. "
12/01/1998 - "These results provide the first evidence that elevated levels of endogenous PI-PLC beta 1 suppress tumor cell growth, but enhance the ability to form cell aggregates and to release carcinoembryonic antigen, an intercellular adhesion molecule."
11/01/1996 - "These findings have prompted us to better characterise the nuclear PLC beta 1. The isoform beta 1 has been studied as a possible target for anti-cancer drugs and as an inducer, via diacylglycerol generation, of the translocation of specific protein kinase C (PKC) isozyme to the nucleus. "
|4.||Schizophrenia (Dementia Praecox)
02/01/2011 - "Our data confirm that phospholipase C beta 1 transcript levels are decreased in the dorsolateral prefrontal cortex from subjects with schizophrenia. "
02/01/2011 - "There was no significant difference in the protein levels of either phospholipase C beta 1 variant in schizophrenia, irrespective of duration of illness (variant a; P = 0.84, variant b; P = 0.73). "
02/01/2011 - "Compared to age/sex matched controls, levels of phospholipase C beta 1 variant a and b mRNAs were decreased (-33% and -50%, respectively) in short duration schizophrenia. "
02/01/2011 - "Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness."
12/15/1999 - "Changes in PLC beta 1 immunoreactivities in the prefrontal and superior temporal cortex of patients with schizophrenia may reflect abnormalities in neurotransmissions via receptors that are coupled with the Gq alpha-PLC beta 1 cascade."
11/01/2007 - "These studies support the suggestion that PLC-beta 3 is an important upstream signaling molecule for PKC epsilon-mediated acute and chronic inflammatory pain."
09/03/2003 - "Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain."
09/03/2003 - "Phospholipase C (PLC) beta4, one of the four isoforms of PLCbetas, is the sole isoform expressed in the mouse ventral posterolateral thalamic nucleus (VPL), a key station in pain processing. "
|1.||Proteins (Proteins, Gene)
|2.||Phospholipase C beta
|3.||Messenger RNA (mRNA)
|5.||Protein Kinase C-epsilon
|8.||antineoplaston A10 (A 10)
|9.||Type C Phospholipases
|10.||Phospholipase C gamma
|1.||Heart Transplantation (Grafting, Heart)