NM23 Nucleoside Diphosphate Kinases

A family of nucleotide diphosphate kinases that play a role in a variety of cellular signaling pathways that effect CELL DIFFERENTIATION; CELL PROLIFERATION; and APOPTOSIS. They are considered multifunctional proteins that interact with a variety of cellular proteins and have functions that are unrelated to their enzyme activity.

Also Known As:

DR-NM23 Nucleoside Diphosphate Kinase; Expressed in Non-Metastatic Cells 2 Protein; Granzyme A-activated DNase; NDP Kinase A; NM23-H2 Nucleoside Diphosphate Kinase; NM23-H3 Nucleoside Diphosphate Kinase; NM23A Nucleoside Diphosphate Kinases; NM23B Nucleoside Diphosphate Kinase; NME1 Nucleoside Diphosphate Kinase; Nm23-H1 Nucleoside Diphosphate Kinase; Non-Metastatic Cells 1 Protein; Nucleoside Diphosphate Kinase 3; Nucleoside Diphosphate Kinase B; Nucleoside Diphosphate Kinase C; Tumor Metastatic Process-Associated Protein; DR NM23 Nucleoside Diphosphate Kinase; Expressed in Non Metastatic Cells 2 Protein; Granzyme A activated DNase; NM23 H2 Nucleoside Diphosphate Kinase; NM23 H3 Nucleoside Diphosphate Kinase; Nm23 H1 Nucleoside Diphosphate Kinase; Non Metastatic Cells 1 Protein; Tumor Metastatic Process Associated Protein; Nucleoside Diphosphate Kinase A

Networked: 73 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Phosphate Group Acceptor)
        Nucleoside-Diphosphate Kinase: 158
        NM23 Nucleoside Diphosphate Kinases: 73
        Nucleoside Diphosphate Kinase D: 1
        human NME1 protein
        human NME2 protein
        human NME3 protein
        human NME5 protein
        human NME6 protein
        mouse NDP kinase 7
        mouse Nme1 protein
        mouse Nme2 protein
        mouse Nme3 protein
        rat Nm23-H1 protein
        rat Nm23-H5 protein

Experts

1.	Wieland, Thomas: 6 articles (10/2020 - 08/2015)
2.	Lascu, Ioan: 4 articles (10/2011 - 08/2006)
3.	Chatterjee, Anupriya: 3 articles (10/2020 - 02/2020)
4.	Georgescauld, Florian: 3 articles (10/2011 - 04/2007)
5.	Lacombe, Marie-Lise: 3 articles (10/2011 - 04/2007)
6.	Kim, Joon: 3 articles (09/2009 - 08/2006)
7.	Eshwaran, Rachana: 2 articles (10/2020 - 05/2020)
8.	Feng, Yuxi: 2 articles (10/2020 - 05/2020)
9.	Schmidt, Martina: 2 articles (10/2020 - 05/2020)
10.	Lomada, Santosh K: 2 articles (05/2020 - 02/2020)

Related Diseases

1.	Neoplasms (Cancer) 11/01/1996 - "The level of nm23-H1/nucleoside diphosphate kinase expression has been reported to correlate inversely with the metastatic potential of some tumors. " 01/01/1996 - "Levels of nm23-H1/nucleoside diphosphate/kinase A expression have been reported to correlate inversely with metastatic potential in some tumors but not in others. " 09/01/2009 - "Nm23-H1 encodes nucleoside diphosphate kinase A (NDPK-A) and is known to have a metastasis suppressive activity in many tumor cells. " 08/01/2006 - "Nm23-H1 encodes nucleoside diphosphate kinase A and acts as a suppressor of metastasis in certain human tumors. " 12/15/1998 - "Tumor sections of the 413 gastric carcinomas were stained with a polyclonal antibody that was raised against the nm23-H1/NDP kinase A, which is identical to the nm23-H1 gene product. "
2.	Neuroblastoma 02/18/2009 - "The point mutation S120G in human nucleoside diphosphate kinase A, identified in patients with neuroblastoma, causes a protein folding defect. " 06/20/1997 - "A point mutation of human nucleoside diphosphate kinase A found in aggressive neuroblastoma affects protein folding." 02/01/1996 - "A high level of nucleoside diphosphate kinase A (NDPK A/nm23-H1) in neuroblastoma is associated with advanced stage disease. " 07/01/2004 - "Nucleoside diphosphate kinase A/nm23-H1 promotes metastasis of NB69-derived human neuroblastoma." 06/01/2000 - "The hexameric structure is important for protein stability, as demonstrated by studies with natural mutants (the Killer-of-prune mutant of Drosophila NDP kinase and the S120G mutant of the human NDP kinase A in neuroblastomas) and with mutants obtained by site-directed mutagenesis. "
3.	Breast Neoplasms (Breast Cancer) 11/01/2008 - "Nm23-H1/nucleoside diphosphate kinase as a key molecule in breast tumor angiogenesis." 01/09/2021 - "Secreted nucleoside diphosphate kinase A and B (NDPK) support breast cancer metastasis. " 01/01/1992 - "Using immunocytochemical methods with an antiserum raised against NDP kinase A, we analysed tissue sections of breast carcinomas and cells in culture derived from a cervical cancer. " 07/01/2004 - "Nucleoside diphosphate kinase A (NDPK-A), encoded by the nm23-H1 gene, acts as a metastasis suppressor in certain human tumors such as breast carcinoma. " 05/06/2020 - "Some highly metastatic types of breast cancer show decreased intracellular levels of the tumor suppressor protein NME1, also known as nm23-H1 or nucleoside diphosphate kinase A (NDPK-A), which decreases cancer cell motility and metastasis. "
4.	Hyperglycemia 10/19/2020 - "Our previous studies identified that retinal endothelial damage caused by hyperglycemia or nucleoside diphosphate kinase-B (NDPK-B) deficiency is linked to elevation of angiopoietin-2 (Ang-2) and the activation of the hexosamine biosynthesis pathway (HBP). "
5.	Neoplasm Metastasis (Metastasis) 12/01/2017 - "Nucleoside diphosphate kinase A (NDPKA) expression before and after transfection was examined, as well as changes in cell invasiveness and metastasis capabilities. " 02/15/2002 - "Crystal structure of human nucleoside diphosphate kinase A, a metastasis suppressor." 04/01/2000 - "Human nucleoside diphosphate kinase A catalyzes phosphoryl transfer and acts as a suppressor of metastasis. " 01/09/2021 - "Secreted nucleoside diphosphate kinase A and B (NDPK) support breast cancer metastasis. " 09/01/2009 - "Nm23-H1 encodes nucleoside diphosphate kinase A (NDPK-A) and is known to have a metastasis suppressive activity in many tumor cells. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Proteins (Proteins, Gene)
3.	Paraffin
4.	Formaldehyde (Formol)
5.	Nucleophosmin
6.	Retinoblastoma-Binding Protein 4
7.	Angiopoietin-2
8.	Proteome
9.	Retinaldehyde (Retinal)
10.	Hexosamines

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)