G-Protein-Coupled Receptor Kinase 3

A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response.

Also Known As:

Networked: 14 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Liang, Zhi-Yong: 2 articles (02/2018 - 01/2017)
2.	Zhou, Li: 2 articles (02/2018 - 01/2017)
3.	Zhou, Wei-Xun: 2 articles (02/2018 - 01/2017)
4.	Li, Wenliang: 2 articles (07/2016 - 01/2014)
5.	Chang, Chun-Chao: 1 article (01/2022)
6.	Chen, Li-Chin: 1 article (01/2022)
7.	Chou, Chia-Lin: 1 article (01/2022)
8.	Fang, Chia-Lang: 1 article (01/2022)
9.	Hseu, You-Cheng: 1 article (01/2022)
10.	Hung, Shih-Ting: 1 article (01/2022)

Related Diseases

1.	Carcinogenesis 01/01/2022 - "This study aimed to examine the relationship between G protein-coupled receptor kinase 3 (GRK3) and gastric cancer prognosis and investigate the role of GRK3 in gastric cancer carcinogenesis. "
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2022 - "This study aimed to examine the relationship between G protein-coupled receptor kinase 3 (GRK3) and gastric cancer prognosis and investigate the role of GRK3 in gastric cancer carcinogenesis. "
3.	Shock 08/01/2011 - "This study examines the effects of unpredictable, inescapable tail-shock stress (TSS) on alpha(2)-adrenoceptor (α(2A)-AR) and corticotropin-releasing factor 1 receptor (CRF(1)-R) regulation as well as protein levels of G protein-coupled receptor kinase 3 (GRK3), GRK2, tyrosine hydroxylase (TH) plus carbonylated protein levels in locus coeruleus (LC), amygdala (AMG), cortex (COR) and striatum (STR). "
4.	Schizophrenia (Dementia Praecox) 02/15/2004 - "Mutation screening and association study of the beta-adrenergic receptor kinase 2 gene in schizophrenia families." 02/15/2004 - "We have reported significant linkage of intermediate phenotypes for schizophrenia with markers within or near the beta-adrenergic receptor kinase 2 (ADRBK2, or GRK3) gene, which is highly expressed in dopaminergic pathways in the central nervous system, and mediates homologous desensitization for a variety of neurotransmitters and hormones through phosphorylation of G protein-coupled receptors (GPCRs). "
5.	Neoplasms (Cancer) 02/01/2018 - "It was found that G-protein-coupled receptor kinase 3 (GRK3) played key biological roles in some cancers. " 01/01/2016 - "G protein coupled receptor kinase 3 (GRK3) is a negative regulator of CXCR4 activity, and we show that GRK expression correlates with tumorigenicity, molecular subtype, and metastatic potential in human tumor microarray analysis. " 01/01/2017 - "Deregulation of G protein-coupled receptor kinase 3 (GRK3), which belongs to a subfamily of kinases called GRKs, acts as a promoter mechanism in some cancer types. " 01/28/2014 - "We discovered that G-protein-coupled receptor kinase 3 (GRK3; or β-adrenergic receptor kinase 2) was not only necessary for survival and proliferation of metastatic cells, but also sufficient to promote primary prostate tumor growth and metastasis upon exogenous expression in poorly metastatic cells in mouse xenograft models. "

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