G-Protein-Coupled Receptor Kinases

A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. They are regulatory proteins that play a role in G-protein-coupled receptor densensitization.

Also Known As:

G Protein Coupled Receptor Kinase; G Protein Coupled Receptor Kinases; Kinase, G-Protein-Coupled Receptor; Kinases, G-Protein-Coupled Receptor; Receptor Kinase, G-Protein-Coupled; Receptor Kinases, G-Protein-Coupled; G-Protein-Coupled Receptor Kinase

Networked: 130 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jose, Pedro A: 11 articles (11/2022 - 03/2002)
2.	Koch, Walter J: 6 articles (10/2018 - 06/2006)
3.	Felder, Robin A: 5 articles (06/2006 - 03/2002)
4.	Mayor, Federico: 4 articles (05/2020 - 01/2006)
5.	Blaxall, Burns C: 4 articles (06/2014 - 06/2006)
6.	Kavelaars, Annemieke: 4 articles (05/2014 - 08/2011)
7.	Willemen, Hanneke L D M: 4 articles (05/2014 - 08/2011)
8.	Zeng, Chunyu: 3 articles (11/2022 - 06/2006)
9.	Ciccarelli, Michele: 3 articles (01/2022 - 12/2008)
10.	Wei, Wei: 3 articles (01/2022 - 11/2018)

Related Diseases

1.	Hypertension (High Blood Pressure) 11/01/2022 - "Abnormal G protein-coupled receptor kinase (GRK)-mediated regulation of GPCR function is involved in the pathogenesis of hypertension. " 03/01/2013 - "G-protein-coupled receptor kinases in hypertension." 06/01/2006 - "We hypothesize that increased activity of G protein-coupled receptor kinase type 4 (GRK4) causes the impaired renal D1 receptor function in hypertension. " 06/01/2006 - "Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression." 05/01/1999 - "G-protein-coupled receptor kinase expression in hypertension."
2.	Heart Failure 03/01/2002 - "1. Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure. " 10/22/2014 - "G protein-coupled receptor kinases (GRKs) have been implicated in human diseases ranging from heart failure to diabetes. " 05/01/2010 - "To explore the correlation of lymphocyte G protein-coupled receptor kinases 2 (GRK2) expression of the very elderly with chronic heart failure (HF) and heart ejection fraction (EF). " 01/01/2010 - "Targeting G protein-coupled receptor kinases (GRKs) in Heart Failure." 08/01/2001 - "G protein-coupled receptor kinases: gotta real kure for heart failure?"
3.	Neoplasms (Cancer) 11/01/2018 - "The role of G protein-coupled receptor kinases in the pathology of malignant tumors." 01/01/2018 - "The Role of G Protein-coupled Receptor Kinases in Cancer." 01/01/2017 - "We further demonstrate for the first time exosomal enrichment of G-protein-coupled receptor kinase (GRK) 5 and GRK6, both of which regulate Src and IGF-IR signaling and have been implicated in cancer. " 10/01/2023 - "Despite G-protein-coupled receptor kinase-interacting protein-1 (GIT1) being recognized as a new promoter gene in some types of cancer, its effect on human pan-cancers and liver hepatocellular carcinoma (LIHC) remains unclear. " 10/01/2023 - "Pan-cancer analysis of the oncogenic effects of G-protein-coupled receptor kinase-interacting protein-1 and validation on liver hepatocellular carcinoma."
4.	Pediatric Obesity 01/01/2017 - "Backgrounds/Objectives:This panel study was to predict the incidences of pediatric obesity by the interaction of sodium (Na) intake and nine single-nucleotide polymorphisms (SNPs) of salt-sensitive genes (SSGs), ACE(angiotensin-converting enzyme), ADD1 G460W,AGT M235T,CYP11β2 (cytochrome P450 family 11-subfamily β-2, -aldosterone synthase),GNB3 C285T,GRK4(A142V)(G-protein-coupled receptor kinases type 4),GRK4 (A486V),NEDD4L (neural precursor cell expressed developmentally downregulated 4 like; rs2288774) and SLC12A3 (solute carrier family 12 (Na/Cl transporters)-member 3), selected from genome-wide association study. "
5.	Pre-Eclampsia (Preeclampsia) 01/01/2021 - "Previous studies have reported that G protein-coupled receptor kinases (GRKs) play a key role in initiating hypertension and hypertensive renal damage, yet little evidence so far suggests a link between GRKs and preeclampsia-related hypertension. "

Related Drugs and Biologics

1.	Sodium
2.	Proteins (Proteins, Gene)
3.	Cytochrome P-450 CYP11B2 (CYP11B2)
4.	Salts
5.	Metoprolol (Toprol-XL)
6.	Particulate Matter
7.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
8.	Solute Carrier Family 12
9.	Cytochrome P450 Family 11
10.	GTP-Binding Proteins (G-Protein)

Related Therapies and Procedures

1.	Therapeutics
2.	Electroacupuncture
3.	Drug Therapy (Chemotherapy)