Cyclic AMP-Dependent Protein Kinase Type I

A cyclic AMP-dependent protein kinase subtype primarily found in the CYTOPLASM. They are tetrameric proteins that contain two catalytic subunits and two type I-specific regulatory subunits.

Also Known As:

Cyclic AMP-Dependent Protein Kinase Type 1; Cyclic AMP Dependent Protein Kinase Type 1; Cyclic AMP Dependent Protein Kinase Type I; Protein Kinase Type I, Cyclic AMP Dependent; Protein Kinase A, Type I; Protein Kinase Type I, Cyclic AMP-Dependent

Networked: 25 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tortora, G: 4 articles (12/2003 - 06/2000)
2.	Ciardiello, Fortunato: 3 articles (12/2003 - 02/2002)
3.	Tortora, Giampaolo: 3 articles (12/2003 - 02/2002)
4.	Bianco, A R: 3 articles (08/2001 - 06/2000)
5.	Bianco, R: 3 articles (08/2001 - 06/2000)
6.	Ciardiello, F: 3 articles (08/2001 - 06/2000)
7.	Damiano, V: 3 articles (08/2001 - 06/2000)
8.	De Placido, S: 3 articles (08/2001 - 06/2000)
9.	Hussain, Muzammal: 2 articles (01/2016 - 12/2015)
10.	Javeed, Aqeel: 2 articles (01/2016 - 12/2015)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2015 - "Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: a potential target for 'two-in-one' cancer chemoimmunotherapeutics." 08/01/2001 - "Protein kinase A type I (PKAI) plays a key role in neoplastic transformation, conveys mitogenic signals from different sources, and is overexpressed in the majority of human tumors. " 11/01/2000 - "Protein kinase A type I (PKAI) plays a key role in neoplastic transformation and is overexpressed in cancer cells in which an EGFR autocrine pathway is activated. " 05/01/1999 - "Expression of the RIalpha regulatory subunit of protein kinase A type I is increased in human cancer cell lines, in primary tumors, in cells after transformation, and in cells upon stimulation of growth. " 05/01/1999 - "The enhanced expression of the RI alpha subunit of cyclic AMP-dependent protein kinase type 1 (PKA-1) has been correlated with cancer cell growth. "
2.	Carney Complex 09/01/2000 - "Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex." 06/01/2002 - "Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex)."
3.	Common Variable Immunodeficiency 01/15/1999 - "Increased activation of protein kinase A type I contributes to the T cell deficiency in common variable immunodeficiency." 06/01/2003 - "Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency--involvement of protein kinase A type I."
4.	Prostatic Neoplasms (Prostate Cancer) 09/01/2009 - "We previously reported that protein kinase A type I (PKA(RIalpha)) overexpression was predictive of outcome in prostate cancer patients treated with radiotherapy (RT) +/- short-term androgen deprivation (STAD) on Radiation Therapy Oncology Group (RTOG) protocol 86-10. "
5.	Neurilemmoma (Schwannoma) 06/01/2002 - "Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit (PRKAR1A) in patients with the "complex of spotty skin pigmentation, myxomas, endocrine overactivity, and schwannomas" (Carney complex)."

Related Drugs and Biologics

1.	Antisense Oligonucleotides
2.	ErbB Receptors (EGF Receptor)
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Hormones (Hormone)
5.	Topoisomerase II Inhibitors
6.	TOR Serine-Threonine Kinases
7.	Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
8.	Cyclooxygenase 2 (Cyclooxygenase-2)
9.	Estrogen Receptor beta
10.	Peroxisome Proliferator-Activated Receptors (PPAR)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Immunotherapy