Interdigitating Dendritic Cell Sarcoma

A rare sarcoma of INTERDIGITATING CELLS found in the lymph nodes and non-lymphoid organs. They exhibit a variable immunophenotype and lack Birbeck granules.

Also Known As:

Dendritic Cell Sarcoma, Interdigitating; Interdigitating Cell Sarcoma; Interdigitating Cell Sarcomas; Sarcoma, Interdigitating Cell; Sarcomas, Interdigitating Cell

Networked: 20 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Histiocytic Sarcoma
3.	Follicular Dendritic Cell Sarcoma
4.	Solitary Fibrous Tumors
5.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Experts

1.	Gu, Bingxin: 1 article (01/2022)
2.	Hu, Silong: 1 article (01/2022)
3.	Liu, Xiaosheng: 1 article (01/2022)
4.	Liu, Xin: 1 article (01/2022)
5.	Luo, Zhiguo: 1 article (01/2022)
6.	Song, Shaoli: 1 article (01/2022)
7.	Wang, Shuoer: 1 article (01/2022)
8.	Xu, Xiaoping: 1 article (01/2022)
9.	Yan, Wangjun: 1 article (01/2022)
10.	Gai, Dong Zheng: 1 article (05/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Interdigitating Dendritic Cell Sarcoma:

1.	Tacrolimus (Prograf)FDA LinkGeneric 06/01/2011 - "We propose that tacrolimus-based immunosuppression was associated with the development of interdigitating dendritic cell sarcoma after liver transplantation in this case."
2.	Vinblastine (Vinblastine Sulfate)FDA Link 06/01/2012 - "Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy."
3.	Proteins (Proteins, Gene)FDA Link 01/01/2018 - "We found that the majority of cases of histiocytic and dendritic cell neoplasms, including histiocytic sarcoma, follicular dendritic cell sarcoma, Langerhans cell histiocytosis, and interdigitating dendritic cell sarcoma, show strong EZH2 expression by immunohistochemical staining, in contrast to benign histiocytic lesions and normal cellular counterparts, which did not show EZH2 expression, suggesting that this molecule may function as an oncogenic protein in these neoplasms. "
4.	S100 Proteins (S 100 Protein)IBA 06/01/2010 - "Interdigitating dendritic cell sarcoma (IDCS) was positive for S-100 protein and fascin and negative for Langerin. "
5.	Immunoglobulin M (IgM)IBA 01/01/1989 - "Three independent mouse monoclonal antibodies (mAbs) ID1 (IgG3), ID2 and ID3 (IgM) were raised against whole cells of a surgically resected human interdigitating cell sarcoma (ICS). "
6.	Immunoglobulin G (IgG)IBA 01/01/1989 - "Three independent mouse monoclonal antibodies (mAbs) ID1 (IgG3), ID2 and ID3 (IgM) were raised against whole cells of a surgically resected human interdigitating cell sarcoma (ICS). "
7.	Doxorubicin (Adriamycin)FDA LinkGeneric 06/01/2012 - "Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy."
8.	Dacarbazine (DIC)FDA LinkGeneric 06/01/2012 - "Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy."
9.	Bleomycin (Blenoxane)FDA LinkGeneric 06/01/2012 - "Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy."
10.	AntigensIBA 01/01/2023 - "Retroperitoneal localization is an extremely rare presentation of interdigitating dendritic cell sarcoma (IDCS), the primary neoplasm of the antigen-presenting interdigitating dendritic cells. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2015 - "Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy." 02/01/2012 - "We had previously experienced successful treatment with ABVD chemotherapy for interdigitating dendritic cell sarcoma after ineffective CHOP chemotherapy. " 07/15/2010 - "Interdigitating dendritic cell sarcoma of the ileum recurred in multiple lymph nodes and duodenum three years after operation without chemotherapy." 01/01/2019 - "[Chemotherapy bridged hematopoietic stem cell transplantation for the treatment of interdigitating dendritic cell sarcoma: a case report and literature review]." 10/27/2014 - "Interdigitating dendritic cell sarcoma presenting in the skin: diagnosis and the role of surgical resection, chemotherapy and radiotherapy in management."
2.	Therapeutics 01/01/2017 - "Interdigitating dendritic cell sarcoma successfully treated with ABVD therapy in which serum CEA levels correlated with disease activity." 01/01/2015 - "In conclusion, we report a case of B-RAF mutation detected in an interdigitating dendritic cell sarcoma patient treated with targeted therapy. " 01/01/2022 - "A 5-year-old male child was diagnosed with interdigitating dendritic cell sarcoma (IDCS) during his maintenance therapy for B-cell precursor acute lymphoblastic leukemia (B-ALL). "
3.	Liver Transplantation 06/01/2011 - "Interdigitating dendritic cell sarcoma following adult liver transplantation: case report and literature review." 06/01/2010 - "Interdigitating dendritic cell sarcoma involving bone marrow in a liver transplant recipient." 06/01/2011 - "We propose that tacrolimus-based immunosuppression was associated with the development of interdigitating dendritic cell sarcoma after liver transplantation in this case."
4.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 02/01/2009 - "[Interdigitating dendritic cell sarcoma of lower extremities resistant to high dose chemotherapy BEAM with peripheral blood stem cell transplantation]."
5.	Hematopoietic Stem Cell Transplantation 01/01/2019 - "[Chemotherapy bridged hematopoietic stem cell transplantation for the treatment of interdigitating dendritic cell sarcoma: a case report and literature review]."