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Elongation Factor 2 Kinase

A monomeric calcium-calmodulin-dependent protein kinase subtype that specifically phosphorylates PEPTIDE ELONGATION FACTOR 2. The enzyme lacks a phosphorylatable activation domain that can respond to CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE KINASE, however it is regulated by phosphorylation by PROTEIN KINASE A and through intramolecular autophosphorylation.
Also Known As:
CAM Kinase III; Cam PK III; E-2 Kinase; EF-2 Kinase; Eukaryotic Elongation Factor-2 Kinase; Protein Kinase CPK3; eEF-2-Specific Ca and Calmodulin-Dependent Protein Kinase III; Calcium Calmodulin Dependent Protein Kinase Type 3; Calmodulin Dependent Protein Kinase III; E 2 Kinase; EF 2 Kinase; Eukaryotic Elongation Factor 2 Kinase; Kinase CPK3, Protein; Kinase, EF-2; eEF 2 Specific Ca and Calmodulin Dependent Protein Kinase III; Calcium-Calmodulin-Dependent Protein Kinase Type 3; Calmodulin-Dependent Protein Kinase III
Networked: 72 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Ozpolat, Bulent: 11 articles (03/2022 - 01/2012)
2. Proud, Christopher G: 7 articles (01/2021 - 05/2015)
3. Kahraman, Nermin: 6 articles (11/2021 - 03/2016)
4. Cheng, Yan: 4 articles (01/2022 - 02/2013)
5. Ay, Mehmet: 3 articles (03/2022 - 01/2020)
6. Wang, Xuemin: 3 articles (01/2021 - 05/2015)
7. Xie, Jianling: 3 articles (01/2020 - 05/2015)
8. Bayraktar, Recep: 3 articles (10/2018 - 02/2017)
9. Lopez-Berestein, Gabriel: 3 articles (10/2018 - 01/2012)
10. Okada, Muneyoshi: 3 articles (01/2016 - 09/2013)

Related Diseases

1. Neoplasms (Cancer)
2. Triple Negative Breast Neoplasms
3. Inflammation (Inflammations)
4. Glioma (Gliomas)
5. Carcinogenesis

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Protein Kinases (Protein Kinase)
3. Eukaryotic Initiation Factor-4E
4. Mitogen-Activated Protein Kinases
5. Peptide Initiation Factors (Initiation Factor)
6. Phosphotransferases (Kinase)
7. Elongation Factor 2 Kinase
8. Peptide Elongation Factor 2 (EF-2)
9. Calcium-Calmodulin-Dependent Protein Kinases
10. rottlerin

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)