|1.||Yang, Jin-Ming: 3 articles (02/2013 - 05/2002)|
|2.||Tavares, Clint D J: 2 articles (01/2016 - 01/2012)|
|3.||Dalby, Kevin N: 2 articles (01/2016 - 01/2012)|
|4.||Werner, Jörn M: 2 articles (05/2015 - 05/2015)|
|5.||Mikolajek, Halina: 2 articles (05/2015 - 05/2015)|
|6.||Proud, Christopher G: 2 articles (05/2015 - 05/2015)|
|7.||Arora, Sonia: 2 articles (10/2003 - 05/2002)|
|8.||Cho, Eun Jeong: 1 article (01/2016)|
|9.||Devkota, Ashwini K: 1 article (01/2016)|
|10.||Wang, Gen-zhu: 1 article (07/2015)|
05/15/2001 - "These studies demonstrate for the first time the activity of GAs against human gliomas in vitro and in vivo and suggest that destruction of EF-2 kinase may be an important cytotoxic mechanism of this unique class of drug."
05/15/2001 - "The ability of GA to inhibit the growth of glioma cells was abrogated by overexpressing EF-2 kinase. "
05/15/2001 - "Because EF-2 kinase is chaperoned by Hsp90, we investigated the effects of GA on the viability of glioma cells, the expression of EF-2 kinase protein, and the interaction between Hsp90 and EF-2 kinase. "
03/01/1997 - "These data suggest that CaM kinase III may be an important link between the activation of CaM-dependent signaling, proliferation, and viability in malignant cells, and that inhibition of CaM kinase III may represent an interesting pharmacological target in malignant gliomas."
03/01/1997 - "Rottlerin decreased growth and induced cytotoxicity in rat (C6) and two human gliomas (T98G and U138MG) at concentrations that inhibited the activity of CaM kinase III in vitro and in vivo. "
01/01/2016 - "Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening."
07/01/2015 - "[Eukaryotic elongation factor 2 kinase and cancer]."
05/01/2015 - "Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival."
03/01/2015 - "Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells."
10/01/2014 - "Eukaryotic elongation factor-2 kinase (eEF2K): a potential therapeutic target in cancer."
|3.||Breast Neoplasms (Breast Cancer)
01/01/1999 - "These results suggest that CaM kinase III may contribute an important link between growth factor/receptor interactions, protein synthesis and the induction of cellular proliferation in human breast cancer."
01/01/1999 - "The specific activity of CaM kinase III in human breast cancer cell lines was equal to or greater than that seen in a variety of cell lines with similar rates of proliferation. "
05/01/2006 - "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells."
01/01/1999 - "To determine the significance of CaM kinase III in breast cancer, we measured the activity of the kinase in human breast cancer cell lines as well as in fresh surgical specimens. "
01/01/2012 - "Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer."
|5.||Atherosclerotic Plaque (Atheroma)
|1.||Elongation Factor 2 Kinase
|2.||Peptide Elongation Factor 2 (EF-2)
|3.||Intercellular Signaling Peptides and Proteins (Growth Factors)
|4.||Protein Kinases (Protein Kinase)
|7.||Peptide Elongation Factors (Elongation Factor)