Cucurbitacins

Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other plants and are noted for intense bitterness.

Also Known As:

Networked: 103 relevant articles (5 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Halaweish, Fathi T: 4 articles (10/2018 - 04/2014)
2.	Wang, Yitao: 3 articles (01/2019 - 09/2012)
3.	Ferreira, Maria-José U: 2 articles (01/2022 - 10/2009)
4.	Ramalhete, Cátia: 2 articles (01/2022 - 10/2009)
5.	Farooqi, Ammad Ahmad: 2 articles (01/2021 - 10/2015)
6.	Alsayari, Abdulrhman: 2 articles (10/2018 - 11/2016)
7.	Ahmed, Mahmoud S: 2 articles (09/2017 - 04/2014)
8.	Caro, Miguel Soriano Balparda: 2 articles (01/2017 - 04/2016)
9.	Durán, Fernando Javier: 2 articles (01/2017 - 04/2016)
10.	Lang, Karen Luise: 2 articles (01/2017 - 04/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Numerous studies have reported the potential tumor-killing activities of cucurbitacins in multiple aspects of human malignancies. " 01/01/2018 - "The present study evaluated the anticancer activity of cucurbitacin-A on ovarian SKVO3 cancer cells. " 06/01/2014 - "Recent studies suggest that the use of cucurbitacins could inhibit cancer cell progression. " 01/01/2014 - "Recent studies suggest that the use of Cucurbitacin could repress cancer cell progression. " 04/01/2012 - "Thus the present study provides new insights into the molecular mechanisms underlying cucurbitacin-mediated cell death and supports cucurbitacin as a potential anti-cancer drug through modulating the balance between autophagic and apoptotic modes of cell death."
2.	Gastroenteritis 05/01/2013 - "Cucurbitacin IIa (CuIIa), a member of cucurbitacin family, is isolated from the root of Hemsleya amabilis which has been used as an ancient remedy for bacillary dysentery and gastroenteritis. " 09/01/2012 - "23,24-dihydrocucurbitacin F (DHCF), a derivative of the cucurbitacin family, has been isolated as an active component from the root of Hemsleya amabilis (Cucurbitaceae), an ancient Chinese remedy for bacillary dysentery, gastroenteritis, and cancers. "
3.	Bacillary Dysentery (Shigellosis) 05/01/2013 - "Cucurbitacin IIa (CuIIa), a member of cucurbitacin family, is isolated from the root of Hemsleya amabilis which has been used as an ancient remedy for bacillary dysentery and gastroenteritis. " 09/01/2012 - "23,24-dihydrocucurbitacin F (DHCF), a derivative of the cucurbitacin family, has been isolated as an active component from the root of Hemsleya amabilis (Cucurbitaceae), an ancient Chinese remedy for bacillary dysentery, gastroenteritis, and cancers. "
4.	Inflammation (Inflammations) 01/01/2009 - "Recently, cucurbitacins have been described as inhibitors of JAK -STAT and NF-AT functions related to inflammation; they were also found to induce apoptosis of cells involved in the inflammatory response. " 01/01/2013 - "Due its inhibitory effects on chemical carcinogenesis and inflammation, Cucurbitacins have been proposed as an effective agent for the prevention or treatment of human cancers. " 02/03/2016 - "Many studies have reported the remarkable and significant properties of dietary plant polyphenols such as curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, epigallocatechin gallate, and cucurbitacin as anticancer agents known for their pleiotropic effects on cancer, immune cells, and inflammation. "
5.	Carcinogenesis 01/01/2013 - "Due its inhibitory effects on chemical carcinogenesis and inflammation, Cucurbitacins have been proposed as an effective agent for the prevention or treatment of human cancers. " 01/01/2014 - "Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. "

Related Drugs and Biologics

1.	Cytostatic Agents
2.	Betulinic Acid
3.	23,24-dihydrocucurbitacin F
4.	cucurbitacin IIa
5.	acetovanillone (apocynin)
6.	Glucosides
7.	Estrone
8.	poly(lactide) (polylactic acid)
9.	Triterpenes
10.	cucurbitacin B

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	bitter melon extract
4.	Drug Therapy (Chemotherapy)
5.	Radiotherapy