HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Cardiotoxins

Agents that have a damaging effect on the HEART. Such damage can occur from ALKYLATING AGENTS; FREE RADICALS; or metabolites from OXIDATIVE STRESS and in some cases is countered by CARDIOTONIC AGENTS. Induction of LONG QT SYNDROME or TORSADES DE POINTES has been the reason for viewing some drugs as cardiotoxins.
Also Known As:
Agents, Cardiotoxic; Cardiotoxic Agents
Networked: 49 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. de Geus-Oei, Lioe-Fee: 2 articles (09/2013 - 04/2011)
2. Bellersen, Louise: 2 articles (09/2013 - 04/2011)
3. Kapusta, Livia: 2 articles (09/2013 - 04/2011)
4. Oyen, Wim J G: 2 articles (09/2013 - 04/2011)
5. van Laarhoven, Hanneke W M: 2 articles (09/2013 - 04/2011)
6. Gotthardt, Martin: 2 articles (09/2013 - 04/2011)
7. Mavinkurve-Groothuis, Annelies M C: 2 articles (09/2013 - 04/2011)
8. Hilfiker-Kleiner, Denise: 2 articles (01/2011 - 09/2007)
9. Wu, Wen-Guey: 2 articles (01/2010 - 01/2006)
10. Ewer, Michael S: 2 articles (01/2008 - 12/2004)

Related Diseases

1. Necrosis
01/01/2010 - "Cobra venom contains cardiotoxins (CTXs) that induce tissue necrosis and systolic heart arrest in bitten victims. "
09/01/2013 - "Third-order functional imaging techniques comprise (123)I-metaiodobenzylguanidine scintigraphy, which images the efferent sympathetic nervous innervations; sympathetic neuronal PET, with its wide range of tracers; (111)In-antimyosin, which is a specific marker for myocardial cell injury and necrosis; (99m)Tc-annexin V scintigraphy, which visualizes apoptosis and cell death; fatty-acid-use scintigraphy, which visualizes the storage of free fatty acids in the lipid pool of the cytosol (which can be impaired by cardiotoxic agents); and (111)In-trastuzumab imaging, to study trastuzumab targeting to the myocardium. "
04/01/2011 - "Third-order functional imaging techniques comprise (123)I-metaiodobenzylguanidine scintigraphy, which images the efferent sympathetic nervous innervations; sympathetic neuronal PET, with its wide range of tracers; (111)In-antimyosin, which is a specific marker for myocardial cell injury and necrosis; (99m)Tc-annexin V scintigraphy, which visualizes apoptosis and cell death; fatty-acid-use scintigraphy, which visualizes the storage of free fatty acids in the lipid pool of the cytosol (which can be impaired by cardiotoxic agents); and (111)In-trastuzumab imaging, to study trastuzumab targeting to the myocardium. "
05/23/1975 - "This Ca-induced high-energy phosphate exhaustion is a crucial point in the etiology of the myocardial fibre necroses produced in rats by large doses of beta-adrenergic catecholamines, particularly isoproterenol, or by a number of other cardiotoxic agents. "
09/01/2008 - "Dependent on the individual genetic predisposition such harmful autoimmune reactions are supposed to emerge as a consequence of heart muscle damage induced by viral triggers, ischemia or exposure to cardiotoxins leading to myocyte apoptosis (and/or necrosis) and subsequent liberation of a "critical amount" of self-antigens previously hidden to the immune system. "
2. Neoplasms (Cancer)
3. Ischemia
11/01/2008 - "Depolarization of the mitochondrial inner membrane potential (DeltaPsi(m)) associated with oxidative stress is thought to be a critical factor in cardiac dysfunction and cell injury following ischemia-reperfusion or exposure to cardiotoxic agents. "
01/01/2011 - "In this regard, STAT3 interacts with a broad range of cellular and molecular mechanisms that direct remodeling processes in cardiac physiology (exercise, pregnancy) and pathophysiology (pressure overload, ischemia/reperfusion, myocardial infarction, and cardiotoxic agents). "
09/01/2008 - "Dependent on the individual genetic predisposition such harmful autoimmune reactions are supposed to emerge as a consequence of heart muscle damage induced by viral triggers, ischemia or exposure to cardiotoxins leading to myocyte apoptosis (and/or necrosis) and subsequent liberation of a "critical amount" of self-antigens previously hidden to the immune system. "
09/01/2007 - "This review summarizes the current knowledge of IL-6 cytokines, gp130 receptor and STAT3 signaling in the heart exposed to physiological (aging, pregnancy) and pathophysiological stress (ischemia, pressure overload, inflammation and cardiotoxic agents) with a special focus on the potential role of individual IL-6 cytokines."
07/01/2007 - "This review summarizes the current knowledge of IL-6 cytokines, gp130 receptor and STAT3 signaling in the heart exposed to physiological (aging, pregnancy) and pathophysiological stress (ischemia, pressure overload, inflammation and cardiotoxic agents) with a special focus on the potential role of individual IL-6 cytokines."
4. Heart Failure
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. trastuzumab (Herceptin)
2. Nonesterified Fatty Acids (NEFA)
3. Proteins (Proteins, Gene)
4. Phospholipases A2 (Phospholipase A2)
5. Snake Venoms (Snake Venom)
6. Cobra Venoms (Cobra Venom)
7. Anthracyclines
8. Reactive Oxygen Species (Oxygen Radicals)
9. Cytokines
10. Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1. Radiotherapy
2. Transplants (Transplant)
3. Liver Transplantation
4. Drug Therapy (Chemotherapy)