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Type 6 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
Also Known As:
Cyclic Nucleotide Phosphodiesterases, Type 6; Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit; Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit; PDE6 Phosphodiesterases; PDE6, alpha Subunit; PDE6, beta Subunit; PDE6, delta Subunit; Phosphodiesterase 6; Phosphodiesterase Type 6; Retinal Phosphodiesterase 6; Retinal Phosphodiesterase, alpha Subunit; Retinal Phosphodiesterase, beta Subunit; Retinal Phosphodiesterase, delta Subunit; Rod cGMP Phosphodiesterase, beta Subunit; alpha Subunit, PDE6; beta Subunit, PDE6; cGMP Phosphodiesterase delta Subunit; cGMP-PDE gamma Subunit; delta Subunit, PDE6; gamma Subunit, cGMP Phosphodiesterase; PDE6 alpha Subunit; PDE6 beta Subunit; PDE6 delta Subunit; Phosphodiesterase 6, Retinal; Phosphodiesterases, PDE6; alpha Subunit PDE6; beta Subunit PDE6; cGMP PDE gamma Subunit; delta Subunit PDE6; gamma Subunit, cGMP-PDE
Networked: 20 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Eichmüller, Stefan B: 3 articles (03/2010 - 03/2007)
2. Schadendorf, Dirk: 3 articles (03/2010 - 03/2007)
3. Bazhin, Alexandr V: 3 articles (03/2010 - 03/2007)
4. Philippov, Pavel P: 3 articles (03/2010 - 03/2007)
5. Rodrigo, Regina: 2 articles (01/2014 - 06/2013)
6. Martínez-Fernández de la Cámara, Cristina: 2 articles (01/2014 - 06/2013)
7. Fletcher, E L: 1 article (04/2014)
8. O'Brien, E E: 1 article (04/2014)
9. Greferath, U: 1 article (04/2014)
10. den Hollander, Anneke I: 1 article (03/2014)

Related Diseases

1. Breast Neoplasms (Breast Cancer)
2. Retinitis Pigmentosa (Pigmentary Retinopathy)
3. Retinal Degeneration
4. Melanoma (Melanoma, Malignant)
5. Night Blindness (Nyctalopia)

Related Drugs and Biologics

1. Transducin
2. Recoverin
3. Arrestin
4. Rhodopsin (Visual Purple)
5. Guanylate Cyclase (Guanylyl Cyclase)
6. 5'-Guanylic Acid (GMP)
7. sildenafil (Viagra)
8. Type 5 Cyclic Nucleotide Phosphodiesterases
9. G-Protein-Coupled Receptor Kinase 1 (G Protein-Coupled Receptor Kinase 1)
10. GTP Phosphohydrolases (GTPases)