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Type 4 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
Also Known As:
Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterase PDE4 Family; Cyclic Nucleotide Phosphodiesterases, Type 4A; Cyclic Nucleotide Phosphodiesterases, Type 4A5; Cyclic Nucleotide Phosphodiesterases, Type 4B; Cyclic Nucleotide Phosphodiesterases, Type 4C; Cyclic Nucleotide Phosphodiesterases, Type 4D; Cyclic Nucleotide Phosphodiesterases, Type 4D3; PDE4 Phosphodiesterases; PDE4D3 Phosphodiesterase; Phosphodiesterase 4; Phosphodiesterase 4A; Phosphodiesterase 4B; Phosphodiesterase 4C; Phosphodiesterase 4D; Phosphodiesterase IV; Phosphodiesterase-4; Type 4 Cyclic Nucleotide Phosphodiesterase; cAMP-Specific Phosphodiesterase 4A5; Phosphodiesterase 4A5, cAMP-Specific; Phosphodiesterase, PDE4D3; Phosphodiesterases, PDE4; cAMP Specific Phosphodiesterase 4A5
Networked: 824 relevant articles (56 outcomes, 114 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zhang, Han-Ting: 14 articles (01/2022 - 08/2004)
2. Rabe, Klaus F: 12 articles (01/2018 - 02/2002)
3. Xu, Jiangping: 11 articles (07/2022 - 01/2014)
4. Wang, Haitao: 10 articles (07/2022 - 01/2014)
5. Yin, Sheng: 10 articles (05/2018 - 01/2014)
6. Luo, Hai-Bin: 9 articles (10/2022 - 05/2012)
7. Tang, Wei: 8 articles (02/2022 - 08/2009)
8. Civelli, Maurizio: 7 articles (10/2022 - 03/2015)
9. Facchinetti, Fabrizio: 7 articles (10/2022 - 03/2015)
10. Li, Heng: 7 articles (02/2022 - 01/2018)

Related Diseases

1. Chronic Obstructive Pulmonary Disease (COPD)
2. Asthma (Bronchial Asthma)
3. Psoriasis (Pustulosis Palmaris et Plantaris)
4. Atopic Dermatitis (Atopic Eczema)
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Phosphodiesterase 4 Inhibitors
2. apremilast
3. Roflumilast
4. Enzymes
5. Janus Kinases
6. Rolipram
7. Isoenzymes
8. Interleukin-17 (Interleukin 17)
9. Janus Kinase Inhibitors
10. Glucocorticoids

Related Therapies and Procedures

1. Therapeutics
2. Ligation
3. Punctures
4. Biological Therapy
5. Nuclear Power Plants