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Primary Effusion Lymphoma

A rare neoplasm of large B-cells usually presenting as serious effusions without detectable tumor masses. The most common sites of involvement are the pleural, pericardial, and peritoneal cavities. It is associated with HUMAN HERPESVIRUS 8, most often occurring in the setting of immunodeficiency.
Also Known As:
Lymphoma, Primary Effusion; Effusion Lymphoma, Primary; Effusion Lymphomas, Primary; Lymphomas, Primary Effusion; Primary Effusion Lymphomas
Networked: 496 relevant articles (12 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Kaposi Sarcoma (Kaposi's Sarcoma)
2. Neoplasms (Cancer)
3. Acquired Immunodeficiency Syndrome (AIDS)
4. Liver Cirrhosis (Hepatic Cirrhosis)
5. Lymphoma (Lymphomas)

Experts

1. Damania, Blossom: 23 articles (01/2015 - 02/2004)
2. Katano, Harutaka: 15 articles (08/2015 - 12/2003)
3. Cesarman, Ethel: 14 articles (10/2015 - 07/2002)
4. Fujimuro, Masahiro: 13 articles (01/2016 - 01/2003)
5. Dittmer, Dirk P: 13 articles (06/2012 - 11/2005)
6. Robertson, Erle S: 11 articles (07/2014 - 01/2006)
7. Schulz, Thomas F: 10 articles (10/2015 - 10/2003)
8. Okada, Seiji: 10 articles (03/2015 - 09/2009)
9. Wang, Ling: 10 articles (01/2014 - 04/2004)
10. Jung, Jae U: 9 articles (10/2014 - 11/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primary Effusion Lymphoma:
1. Multi-centric Castleman's DiseaseIBA
2. DNA (Deoxyribonucleic Acid)IBA
3. bortezomib (Velcade)FDA Link
4. cidofovir (Vistide)FDA Link
5. Ribonuclease P (RNase P)IBA
6. rituximab (Mabthera)FDA Link
7. AntibodiesIBA
05/01/2000 - "However, the specificity and sensitivity of these assays are not completely defined due to the lack of a "gold standard." Although IFAs based on primary effusion lymphoma (PEL) cell lines are used widely, the assays can be confounded by nonspecific reactions against cellular components and potential cross-reaction with antibodies against other herpesviruses. "
01/01/2006 - "Colorimetric caspase assay, flow cytometry, and immunoblotting with antibodies against apoptosis-related molecules revealed that GCV has cytotoxic activity toward KSHV-infected primary effusion lymphoma cells, while ACV has weak or little activity. "
05/01/1999 - "Since regression of KS can be achieved by treatment of the patients with alpha interferon (IFN-alpha), we analyzed the effects of IFN-alpha or anti-IFN-alpha antibodies (Ab) on HHV-8 latently infected primary effusion lymphoma-derived cell lines (BCBL-1 and BC-1) and on peripheral blood mononuclear cells (PBMC) from patients with all forms of KS and from at-risk subjects. "
06/15/2010 - "Distinct profiles of antibodies to Kaposi sarcoma-associated herpesvirus antigens in patients with Kaposi sarcoma, multicentric Castleman disease, and primary effusion lymphoma."
04/10/2000 - "To investigate the expression of human herpesvirus 8 (HHV8)-encoded proteins in the cells of primary effusion lymphoma (PEL), Kaposi's sarcoma (KS) and multicentric Castleman's disease (MCD), nine rabbit polyclonal antibodies to K2, ORF26, K8, K8.1, K10, K11, ORF59, ORF65, and ORF73 were developed. "
8. Ganciclovir (Cytovene)FDA LinkGeneric
9. sobuzoxaneIBA
10. lenalidomide (CC 5013)FDA Link

Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Heterologous Transplantation (Xenotransplantation)
3. Radiotherapy
4. Transplants (Transplant)
5. Transplantation (Transplant Recipients)