|1.||Palmer, Jerry P: 3 articles (12/2009 - 10/2003)|
|2.||Sanjeevi, C B: 2 articles (04/2002 - 05/2000)|
|3.||Trembleau, S: 2 articles (10/2001 - 12/2000)|
|4.||Adorini, L: 2 articles (10/2001 - 12/2000)|
|5.||Gregori, S: 2 articles (10/2001 - 12/2000)|
|6.||Penna, G: 2 articles (10/2001 - 12/2000)|
|7.||Eisenbarth, G S: 2 articles (04/2001 - 10/2000)|
|8.||Kawasaki, E: 2 articles (10/2000 - 01/2000)|
|9.||Christie, Michael R: 1 article (11/2014)|
|10.||Feltbower, Richard G: 1 article (11/2014)|
|1.||Type 1 Diabetes Mellitus (Autoimmune Diabetes)
10/01/2001 - "This is associated with the selective inhibition of the response to insulinoma-associated protein 2 (IA-2), an autoantigen in IDDM. "
12/15/2000 - "The insulinoma-associated protein 2 (IA-2) is a phosphatase-like autoantigen inducing T and B cell responses associated with human insulin-dependent diabetes mellitus (IDDM). "
04/01/1997 - "Autoantibody against ICA512 did not improve test sensitivity for slowly progressive IDDM in adults."
03/01/1997 - "ICA512 radioassay, in combination with GAD assay may provide a useful diagnostic marker for IDDM especially in youth."
09/01/1996 - "The insulin-dependent diabetes mellitus-associated ICA 105 autoantigen in stiff-man syndrome patients."
05/01/1994 - "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma."
01/15/2008 - "We now show that knockdown of ICA512 decreases cyclin D1 levels and proliferation of insulinoma INS-1 cells, whereas beta-cell regeneration is reduced in partially pancreatectomized ICA512-/- mice. "
12/01/2009 - "Autoantibodies to GAD 65 (GAD65), insulinoma-associated antigen-2 (ICA512), and insulin (micro-IAA [mIAA]) were also measured. "
04/01/2001 - "It is unclear why patients lose tolerance to IA-2 (insulinoma-associated tyrosine phosphatase-like protein, or islet cell antigen 512 [ICA512]), especially because IA-2 polymorphisms are not associated with type 1 diabetes. "
01/01/2000 - "From a large population-based sample of unrelated Japanese patients with type 1 diabetes, 28 patients who lacked autoantibodies to glutamic acid decarboxylase, islet cell antigen 512/insulinoma-associated antigen-2, phogrin (phosphate homolog of granules of insulinoma)/insulinoma-associated antigen-2beta, and insulin at the onset of type 1 diabetes were examined by PCR-based direct sequencing of the 10 exons, flanking introns, and the promoter region of the HNF-1alpha gene. "
07/26/1996 - "It is closely related to the diabetic autoantigen ICA512 (IA-2) (42% identity overall; 80% in the 260-amino acid PTP domain) and thus a potential target of autoimmunity in diabetes mellitus."
12/01/1998 - "Antibodies directed against the ectodomain of ICA512: is there any evidence in patients with diabetes mellitus?"
09/01/2014 - "About half of the youth onset diabetes mellitus patients from north India had presence of pancreatic autoimmunity in the form of GAD, ICA512/IA2, and insulin antibodies or a combination of antibodies suggestive of having type 1 DM. "
10/01/2000 - "The receptor tyrosine phosphatase like-protein ICA512/IA-2 occurs as a proteolytically-processed 65,000 Mr type 1 transmembrane glycoprotein in beta cells and is a major autoantigen of Type I (insulin-dependent) diabetes mellitus. "
|4.||Type 2 Diabetes Mellitus (MODY)
05/01/2000 - "We analysed serum samples from 600 adult subjects with a clinical diagnosis of type 2 diabetes mellitus for the presence and levels of GAD65Ab and antibodies directed against the islet autoantigen IA-2/ICA512 (IA-2/ICA512Ab). "
05/01/1997 - "Absence of antibodies to ICA512/IA-2 in NIDDM patients with the mitochondrial DNA bp 3243 mutation."
08/01/1997 - "We determined GAD and islet cell (ICA512) autoantibodies from 215 NIDDM individuals and from 14 individuals with impaired glucose tolerance (IGT) of 68 families, including 1 family with maturity-onset diabetes of the young (MODY) and 3 families ascertained specifically for a mixture of NIDDM and IDDM. "
09/01/1999 - "This was a prospective study that analyzed the clinical characteristics, insulin secretion indices, immunological markers (islet cell, GAD, ICA512, and insulin autoantibodies), and HLA susceptibility genes (DR/DQ) in 131 patients with DKA (77 obese and 54 lean), 51 obese patients with hyperglycemia but no DKA, and 25 nondiabetic subjects. "
06/01/2008 - "All patients presented relatively low insulin levels during hyperglycemia, normal BMI, and negative autoantibodies (GAD antibody, insulinoma-associated protein 2, and islet cell antibody). "
|3.||HLA-DR4 Antigen (HLA DR4 Antigen)
|5.||Glutamate Decarboxylase (Decarboxylase, Glutamate)
|6.||Class 8 Receptor-Like Protein Tyrosine Phosphatases
|9.||Proteins (Proteins, Gene)
|10.||Complementary DNA (cDNA)