|1.||Papadimitriou, Evangelia: 4 articles (02/2016 - 04/2009)|
|2.||Hirayama, Toshiya: 4 articles (01/2010 - 03/2003)|
|3.||Mikelis, Constantinos: 3 articles (07/2013 - 04/2009)|
|4.||Tang, Xiufeng: 3 articles (10/2008 - 02/2003)|
|5.||Davies, Jeannette E: 3 articles (10/2008 - 02/2003)|
|6.||Perez-Pinera, Pablo: 3 articles (12/2007 - 06/2007)|
|7.||Lamszus, Katrin: 3 articles (09/2006 - 12/2003)|
|8.||Westphal, Manfred: 3 articles (09/2006 - 12/2003)|
|9.||Nikolich, Karoly: 3 articles (02/2006 - 06/2004)|
|10.||Wada, Akihiro: 3 articles (09/2005 - 03/2003)|
09/01/2006 - "Our findings suggest that antagonization of PTPzeta/RPTPbeta expression can inhibit glioma growth in vivo and may thus represent a potentially promising treatment strategy."
05/01/2009 - "In the same line, PTN decreased migration of different glioma cell lines that express RPTPbeta/zeta but do not express alpha(nu)beta(3), while it stimulated migration of U87MG cells that express alpha(nu)beta(3) on their cell membrane. "
11/01/2006 - "Our observations indicated that LRRC4 may be a negative regulator of the RPTP-zeta receptor, and contribute to suppressing the invasion ability of gliomas cells."
09/01/2006 - "In addition, PTN can induce glioma cell migration which is at least in part mediated through binding to PTPzeta/RPTPbeta. "
02/01/1998 - "Our data suggests there may be a correlation between the loss of transcripts encoding the receptor forms of RPTPzeta/beta and progression from low to high grade gliomas. "
02/15/2006 - "Here, we show that RPTPbeta is expressed in a variety of solid tumor types with low expression in normal tissue. "
02/15/2006 - "RPTPbeta expression is largely restricted to the central nervous system and overexpressed primarily in astrocytic tumors. "
12/01/2003 - "PTPzeta/RPTPbeta immunoreactivity was associated with increasing malignancy grade and localized predominantly to the tumor cells. "
06/29/2007 - "This study thus supports the possibility that activated ALK may be important in human breast cancers and potentially activated either through the PTN/RPTPbeta/zeta signaling pathway, or, alternatively, as an activated fusion protein to stimulate progression of breast cancer in humans."
06/01/2010 - "Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells."
|3.||Glioblastoma (Glioblastoma Multiforme)
04/01/2005 - "In order to study functional differences between long and short RPTPbeta, we created stable U87 glioblastoma cells that expressed these receptors. "
11/01/2006 - "LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression."
12/20/2005 - "Targeting of the PTN receptors, ALK and RPTP-zeta, indicates a contribution of PTN-activated signaling pathways in glioblastomas. "
04/01/2005 - "Functional comparison of long and short splice forms of RPTPbeta: implications for glioblastoma treatment."
06/01/2004 - "Receptor protein tyrosine phosphatase zeta as a therapeutic target for glioblastoma therapy."
|4.||Schizophrenia (Dementia Praecox)
10/05/2008 - "A recent study has reported that MAGI1, MAGI2, and protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1; located on 7q31.3) gene products regulate the NRG1-ERBB4 signaling pathway, and PTPRZ1 is associated with schizophrenia in a Caucasian population. "
02/01/2008 - "PTPRZ1, which codes for RPTPbeta, showed significant, gene-wide and hypothesis-wide association with schizophrenia in our study (best individual single-nucleotide polymorphism allelic P=0.0003; gene-wide P=0.0064; hypothesis-wide P=0.026). "
10/05/2008 - "No association between the protein tyrosine phosphatase, receptor-type, Z Polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population."
02/01/2008 - "Furthermore, the data indicate a role for RPTPbeta in the modulation of ERBB4 signaling that may in turn provide further support for an important role of neuregulin/ERBB4 signaling in the molecular basis of schizophrenia."
02/01/2008 - "The data provide evidence for a role of PTPRZ1, and for RPTPbeta signaling abnormalities, in the etiology of schizophrenia. "
|5.||Astrocytoma (Pilocytic Astrocytoma)
04/01/2005 - "A study of normal brain tissue and graded astrocytomas indicates that long and short RPTPbeta forms have an overlapping expression pattern. "
04/01/1999 - "We observed a strong binding of F3IgFc-coated fluorospheres to astrocytes in neural primary cultures and to C6 astrocytoma cells, and demonstrated, in antibody perturbation experiments, that F3-Ig binding on astrocytes depends on its interaction with PTPzeta/RPTPbeta. "
12/01/2003 - "Expression and function of the receptor protein tyrosine phosphatase zeta and its ligand pleiotrophin in human astrocytomas."
02/01/2001 - "Adhesion and spreading of SF763T astrocytoma cells expressing RPTPbeta on tenascin C was specifically abolished by the addition of a soluble fragment containing the FNIII domain of the receptor. "
11/12/1998 - "We applied a DNA-fingerprinting method based on the PCR-amplification of conserved domains of gene families and observed IL-1-dependent induction of two PTP's, cytoplasmic PTPvarepsilon and receptor-PTPgamma, RPTPgamma, in human U373-MG astrocytoma cells. "
|4.||Protein Tyrosine Phosphatases
|5.||Proteins (Proteins, Gene)
|6.||Small Interfering RNA (siRNA)
|8.||Protein-Tyrosine Kinases (Tyrosine Kinase)
|9.||Fibrinogen (Factor I)
|1.||Heterologous Transplantation (Xenotransplantation)
|4.||Infusion Pumps (Infusion Pump)