HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Non-Receptor Type 22 Protein Tyrosine Phosphatase

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
Also Known As:
Protein Tyrosine Phosphatase, Non-Receptor Type 22; Lymphoid Phosphatase; Lyp1 PTPase; Lyp2 PTPase; PTPN-22 Protein; PTPase Lyp; Protein-Tyrosine Phosphatase Lyp; Tyrosine Protein Phosphatase, Non-Receptor Type 22; PTPN 22 Protein; PTPase, Lyp1; PTPase, Lyp2; Protein Tyrosine Phosphatase Lyp; Protein Tyrosine Phosphatase, Non Receptor Type 22; Tyrosine Protein Phosphatase, Non Receptor Type 22
Networked: 76 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Lang, Silvia: 5 articles (12/2021 - 01/2013)
2. Scharl, Michael: 5 articles (12/2021 - 01/2013)
3. Spalinger, Marianne R: 5 articles (12/2021 - 01/2013)
4. Gottier, Claudia: 4 articles (12/2021 - 09/2017)
5. Rogler, Gerhard: 4 articles (11/2019 - 01/2013)
6. Schwarzfischer, Marlene: 3 articles (12/2021 - 01/2019)
7. Dai, Xuezhi: 3 articles (11/2019 - 09/2017)
8. Atrott, Kirstin: 2 articles (12/2021 - 01/2019)
9. Geirnaert, Annelies: 2 articles (11/2019 - 01/2019)
10. Hering, Larissa: 2 articles (11/2019 - 01/2019)

Related Diseases

1. Autoimmune Diseases (Autoimmune Disease)
2. Type 1 Diabetes Mellitus (Autoimmune Diabetes)
3. Rheumatoid Arthritis
4. Vitiligo
03/01/2017 - "We performed a meta-analysis of a total of seven studies consisting of 2094 cases and 3613 controls to evaluate the possible association of protein tyrosine phosphatase, non-receptor type 22 +1858C>T polymorphism with vitiligo susceptibility. "
03/01/2017 - "Several studies have demonstrated the association of protein tyrosine phosphatase, non-receptor type 22 +1858C→T polymorphism with vitiligo. "
03/01/2017 - "In conclusion, protein tyrosine phosphatase, non-receptor type 22 +1858 T allele predisposes European individuals to vitiligo."
03/01/2017 - "Stratifying data by ethnicity showed an association of protein tyrosine phosphatase, non-receptor type 22 +1858C→T with vitiligo in European population (odds ratio = 1.53, 95% confidence interval [1.34-1.75], P< 0.001) but not in Asian population (odds ratio = 0.59, 95% confidence interval [0.26-1.32], P = 0.2). "
03/01/2017 - "Meta-analysis showed an overall significant association of protein tyrosine phosphatase, non- receptor type 22 +1858C→T polymorphism with vitiligo in all models (allelic model [T vs. C]: odds ratio = 1.50, 95% confidence interval [1.32-1.71], P< 0.001; dominant model [TT + CT vs. CC]: odds ratio = 1.61, 95% confidence interval [1.16-2.24], P = 0.004; recessive model [TT vs. CT + CC]: odds ratio = 4.82, 95% confidence interval [1.11-20.92], P = 0.04; homozygous model [TT vs. CC]: odds ratio = 5.34, 95% confidence interval [1.23-23.24], P = 0.03; co-dominant model [CT vs. CC]: odds ratio = 1.52, 95% confidence interval [1.09-2.13], P = 0.01). "
5. Scleritis (Episcleritis)

Related Drugs and Biologics

1. Phosphoric Monoester Hydrolases (Phosphatases)
2. Tyrosine (L-Tyrosine)
3. T-Cell Antigen Receptors (T-Cell Receptor)
4. STAT4 Transcription Factor
5. Neopterin
6. Rheumatoid Factor
7. Antibodies
8. Anti-Citrullinated Protein Antibodies
9. cyclic citrullinated peptide
10. Proteins (Proteins, Gene)