Non-Receptor Type 12 Protein Tyrosine Phosphatase

A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Rhee, Inmoo: 2 articles (01/2019 - 03/2009)
2.	Espejo, Rosario: 2 articles (02/2014 - 08/2010)
3.	Rengifo-Cam, William: 2 articles (02/2014 - 08/2010)
4.	Sastry, Sarita K: 2 articles (02/2014 - 08/2010)
5.	Lu, Zhimin: 2 articles (02/2013 - 11/2011)
6.	Zheng, Yanhua: 2 articles (02/2013 - 11/2011)
7.	Chen, Guoxian: 1 article (01/2022)
8.	Lai, Jiankun: 1 article (01/2022)
9.	Wang, Xinwen: 1 article (01/2022)
10.	Wang, Xinwu: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Protein tyrosine phosphatase non-receptor type 12 (PTPN12) is abnormally expressed in many human cancers. " 01/01/2014 - "Protein tyrosine phosphatase non-receptor type 12 (PTPN12), has been identified as a potent tumor suppressor in human cancers and a critical regulator of cell adhesion and migration. " 11/01/2011 - "These findings uncover an important mechanism for the regulation of PTP-PEST in activated Ras-induced tumor progression." 10/01/2006 - "These data demonstrate the existence of PTP-PEST variants that might be meaningful for human cancer and underscore the need for further characterizing PTP-PEST and its signaling pathways in context of this disease." 03/01/2023 - "Protein tyrosine phosphatase non-receptor type 12 suppresses tumor progression in osteosarcoma cells."
2.	Neoplasm Metastasis (Metastasis) 09/06/2013 - "Moreover, these results open new avenues by which PTP-PEST regulates cellular migration, a hallmark of metastasis. " 11/01/2011 - "Isomerization of the phosphorylated PTP-PEST by PIN1 increases the interaction between PTP-PEST and FAK, which leads to the dephosphorylation of FAK Y397 and the promotion of migration, invasion, and metastasis of v-H-Ras-transformed cells. " 10/01/2006 - "PTP-PEST, a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, and may be involved in metastasis. " 08/15/2008 - "Together, these data suggest that in colorectal carcinogenesis, elevation of c-Src or down-regulation of SHP-2 and/or PTP-PEST may promote cancer metastases and invasion by regulating villin-induced cell migration and cell invasion."
3.	Carcinoma (Carcinomatosis) 09/01/2015 - "Protein tyrosine phosphatase non-receptor type 12 (PTPN12) has been shown to be involved in the development of a number of types of carcinoma. " 08/01/2010 - "Using colon carcinoma cells, we show that the expression level of PTP-PEST regulates cell motility. " 08/01/2010 - "Either transient small interfering RNA or stable short hairpin RNA knockdown of PTP-PEST enhances haptotactic and chemotactic migration of KM12C colon carcinoma cells. " 02/01/2014 - "Stable shRNA knockdown of PTP-PEST in colon carcinoma cells results in an increased cytosolic pool of p120 concomitant with its enhanced tyrosine phosphorylation and decreased association with E-cadherin. "
4.	Leukemia 05/01/2014 - "Here, we determined the role of PTP-PEST (encoded by PTPN12) in the regulation of mast cell activation using the RBL-2H3 rat basophilic leukemia cell line as a model. " 06/01/2008 - "We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically downregulated in CD4(+) and CD8(+) primary human T cells upon T cell activation. "
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "Protein tyrosine phosphatase non-receptor type 12 (PTPN12), negatively regulated by miR-106a-5p, suppresses the progression of hepatocellular carcinoma." 10/21/2020 - "Decreases in PTP-PEST expression correlate with aggressive phenotypes in hepatocellular carcinoma (HCC). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Protein Tyrosine Phosphatases
3.	Tyrosine (L-Tyrosine)
4.	Phosphoric Monoester Hydrolases (Phosphatases)
5.	6-pyruvoyltetrahydropterin synthase (PTPS)
6.	Non-Receptor Type 12 Protein Tyrosine Phosphatase
7.	Small Interfering RNA (siRNA)
8.	Cadherins (E-Cadherin)
9.	Messenger RNA (mRNA)
10.	Non-Receptor Type 2 Protein Tyrosine Phosphatase

Related Therapies and Procedures

1.	Immunotherapy