A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.
Also Known As:
Protein Tyrosine Phosphatase, Non-Receptor Type 12; PEP PTPase; PEP Protein Tyrosine Phosphatase; PEST-Enriched Phosphatase; PTP-PEST; PEST Enriched Phosphatase; PTPase, PEP; Phosphatase, PEST-Enriched; Protein Tyrosine Phosphatase, Non Receptor Type 12