|1.||Sastry, Sarita K: 2 articles (02/2014 - 08/2010)|
|2.||Rengifo-Cam, William: 2 articles (02/2014 - 08/2010)|
|3.||Espejo, Rosario: 2 articles (02/2014 - 08/2010)|
|4.||Lu, Zhimin: 2 articles (02/2013 - 11/2011)|
|5.||Zheng, Yanhua: 2 articles (02/2013 - 11/2011)|
|6.||Palmer, Helen E F: 1 article (05/2014)|
|7.||Mashima, Keisuke: 1 article (05/2014)|
|8.||Honda, Reika: 1 article (05/2014)|
|9.||Koizumi, Karen: 1 article (05/2014)|
|10.||Maruyama, Atsuko: 1 article (05/2014)|
01/01/2014 - "Protein tyrosine phosphatase non-receptor type 12 (PTPN12), has been identified as a potent tumor suppressor in human cancers and a critical regulator of cell adhesion and migration. "
02/01/2013 - "PTP-PEST activity can be regulated transcriptionally via gene deletion or mutation in several types of human cancers or via post-translational modifications, including phosphorylation, oxidation, and caspase-dependent cleavage. "
11/01/2011 - "These findings uncover an important mechanism for the regulation of PTP-PEST in activated Ras-induced tumor progression."
10/01/2006 - "These data demonstrate the existence of PTP-PEST variants that might be meaningful for human cancer and underscore the need for further characterizing PTP-PEST and its signaling pathways in context of this disease."
10/01/2006 - "PTP-PEST phosphatase variations in human cancer."
|2.||Neoplasm Metastasis (Metastasis)
09/06/2013 - "Moreover, these results open new avenues by which PTP-PEST regulates cellular migration, a hallmark of metastasis. "
11/01/2011 - "Isomerization of the phosphorylated PTP-PEST by PIN1 increases the interaction between PTP-PEST and FAK, which leads to the dephosphorylation of FAK Y397 and the promotion of migration, invasion, and metastasis of v-H-Ras-transformed cells. "
10/01/2006 - "PTP-PEST, a ubiquitously expressed cytoplasmic tyrosine phosphatase, is thought to play an important role in cell adhesion and motility, and may be involved in metastasis. "
08/15/2008 - "Together, these data suggest that in colorectal carcinogenesis, elevation of c-Src or down-regulation of SHP-2 and/or PTP-PEST may promote cancer metastases and invasion by regulating villin-induced cell migration and cell invasion."
05/01/2014 - "Here, we determined the role of PTP-PEST (encoded by PTPN12) in the regulation of mast cell activation using the RBL-2H3 rat basophilic leukemia cell line as a model. "
06/01/2008 - "We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically downregulated in CD4(+) and CD8(+) primary human T cells upon T cell activation. "
08/01/2010 - "Using colon carcinoma cells, we show that the expression level of PTP-PEST regulates cell motility. "
08/01/2010 - "Either transient small interfering RNA or stable short hairpin RNA knockdown of PTP-PEST enhances haptotactic and chemotactic migration of KM12C colon carcinoma cells. "
02/01/2014 - "Stable shRNA knockdown of PTP-PEST in colon carcinoma cells results in an increased cytosolic pool of p120 concomitant with its enhanced tyrosine phosphorylation and decreased association with E-cadherin. "
|5.||Breast Neoplasms (Breast Cancer)
12/01/2012 - "Protein tyrosine phosphatase non-receptor type 12 (PTPN12) is a recently identified tumor suppressor gene (TSG) that is frequently compromised in human triple-negative breast cancer. "
10/01/2006 - "A search for sequence variations within the gene PTPN12 (alias PTP-PEST) was performed in breast cancer cell lines, leading to the identification of three amino acid substitutions at positions 322, 573, and 709. "
|1.||Small Interfering RNA (siRNA)
|3.||Messenger RNA (mRNA)
|5.||GTP Phosphohydrolases (GTPases)
|6.||Protein Tyrosine Phosphatases
|8.||Proteins (Proteins, Gene)
|10.||Pyogenic arthritis, pyoderma gangrenosum, and acne